Results 211 to 220 of about 52,504 (265)

Glymphatic System Dysfunction in Central Nervous System Diseases

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
Glymphatic Dysfunction in Neurological Disorders: The glymphatic system is a brain‐wide clearance system that removes neurotoxic waste via AQP4‐mediated CSF‐ISF exchange. Dysfunction through AQP4 mislocalization, BBB injury, and inflammation annihilates clearance and causes acute (stroke, TBI) and chronic disease.
Anwar Zahran, Omar Abu‐Khazneh, Mohammad Bdair, Orabi Hajjeh, Mohammed AbuBaha, Waseem Shehadeh, Ameer Awashra, Ibrahim Alazizi, Raya Fuqha, Sakeena Saife, Hasan Fuqha, Fathi Milhem, Husam Hamshary, Dana Abuzahra, Umar Shuaib   +14 more
wiley   +1 more source

IL‐17A Promotes NETs Formation via the PKCζ–ERK–ROS–PAD4 Pathway in a Mouse Model of Ischemic Stroke

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
Our study demonstrates that IL‐17A promotes NET formation by upregulating PAD4 through the PKCζ–ERK–ROS pathway, thereby exacerbating ischemic brain injury. IL‐17A regulates NET formation through this newly identified molecular pathway, and targeting this pathway may offer a novel therapeutic strategy for stroke.
Chang Liu, Qi Chen, Weijia Chen, Xinyue Han, Xiaowen Qiao, Jun Guo, Wei Su, Qingqing Dai   +7 more
wiley   +1 more source

HSDL2 Suppresses Epileptic Seizures Through Phosphorylation‐Dependent Modulation of the PSD95‐NMDAR Signaling Axis

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
In a kainic acid‐induced mouse model of epilepsy, upregulation of HSDL2 in the hippocampus prolonged seizure latency, increased the membrane expression of PSD95, and enhanced its phosphorylation. Concurrently, HSDL2 attenuated the interaction between PSD95 and the NMDAR subunits GluN2A/GluN2B, thereby suppressing NMDAR overactivation, reducing ...
Yan Xia, Wang Jing, Zhang Hui, Xu Demei, Peng Xi, Wang Liang   +5 more
wiley   +1 more source

Fetal Pain Perception: Legislative Assertions and Developmental Neuroscience

Annals of the Child Neurology Society, Volume 4, Issue 1, Page 15-28, March 2026.
ABSTRACT Background Pain perception is a conscious experience, but neither pain nor consciousness is defined in the developing human fetus. Emergent consciousness may be regarded as a phenomenon that ultimately arises from an essential minimum of functional neuronal connectivity. Proposed U.S.
William D. Graf, Timothy M. Crombleholme, Leon G. Epstein, Dawn Gano, Phillip L. Pearl, Timothy V. Salomons, Mark S. Scher, Elise Turk, Klaus‐Peter Zimmer, Harvey B. Sarnat   +9 more
wiley   +1 more source

A Novel Role for Lupeol in Hepatocellular Carcinoma Treatment via Promoting Autophagy to Suppress Exosome Secretion

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
Schematic representation of the mechanism by which Lupeol inhibits HCC progression via the autophagy‐exosome axis. ABSTRACT Hepatocellular carcinoma (HCC) is a highly lethal malignancy presenting a considerable challenge due to limited therapeutic options. This study investigates the anti‐cancer mechanisms of Lupeol, a natural triterpenoid. Our results
Xin Zhang, Kehan Chen, Chuyao Zheng, Dai‐yuan Liao, Jian‐Song Wang, Ling‐Li Wang   +5 more
wiley   +1 more source

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Cervical cord compression due to a hypoplastic atlas

Journal of Neurosurgery: Spine, 2001
✓ The authors report the case of a 66-year-old man with progressive, nontraumatic, C-1 cord compression who presented with a complete but hypoplastic atlas. They review six cases found in the literature. Symptoms usually develop in the late adulthood; the sagittal diameter of the canal measures 10 mm or less.
May, Daniel Marc, Jenny, Benoît John, Faundez, Antonio   +2 more
openaire   +3 more sources

Cervical Myelopathy Due to a Hypoplastic Atlas

Neurosurgery Quarterly, 2008
Congenital hypoplasia of the atlas is a rare cause of cervical myelopathy. We report a case of a 30-year-old man with cervical myelopathy caused by spinal stenosis at the level of the atlas associated with a hypoplastic but complete posterior arch of C1.
Bulent Duz, Metin Kaplan, Ozkan Tehli, Serdar Kahraman   +3 more
openaire   +1 more source

Magnetic resonance imaging atlas of the cervical spine musculature

Clinical Anatomy, 2016
The anatomy of the cervical spine musculature visible on magnetic resonance (MR) images is poorly described in the literature. However, the correct identification of individual muscles is clinically important because certain conditions of the cervical spine, for example whiplash associated disorders, idiopathic neck pain, cervical nerve root avulsion ...
John, Au, Diana M, Perriman, Mark R, Pickering, Graham, Buirski, Paul N, Smith, Alexandra L, Webb   +5 more
openaire   +2 more sources

Atlas of Craniocervical Junction and Cervical Spine Surgery

2017
Atlas of craniocervical Junction and cervical spine ...
Boriani S., Presutti L., Gasbarrini A., Mattioli F.   +3 more
openaire   +2 more sources

Cervical Myelopathy Caused by Anomalies at the Level of Atlas

Spine, 2010
Case report.To report a case of cervical myelopathy due to simultaneous anomalies at the level of atlas involving hypoplasia of the posterior arch of the atlas, partial ossification of the transverse atlantal ligament, and hypertrophy of the dens.Hypoplasia of the posterior arch of the atlas, ossification of the transverse atlantal ligament, and ...
Jia-Guang, Tang, Shu-xun, Hou, Wei-Lin, Shang, Wen-Wen, Wu   +3 more
openaire   +2 more sources