Results 51 to 60 of about 43,554 (264)

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Spinal canal stenosis at the level of Atlas

Journal of Craniovertebral Junction and Spine, 2011
We report here a rare case of high cervical stenosis at the level of atlas who presented with progressively deteriorating quadriparesis and respiratory distress.
Suchanda Bhattacharjee, Vijayasaradhi Mudumba, Purohit K Aniruddh   +2 more
doaj   +1 more source

Construction of Gene Modules and Analysis of Prognostic Biomarkers for Cervical Cancer by Weighted Gene Co-Expression Network Analysis

Frontiers in Oncology, 2021
BackgroundDespite advances in the understanding of neoplasm, patients with cervical cancer still have a poor prognosis. Identifying prognostic markers of cervical cancer may enable early detection of recurrence and more effective treatment.MethodsGene ...
Jiamei Liu, Shengye Liu, Xianghong Yang
doaj   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Bony bridges and selected variations of the first cervical vertebra (Atlas): A brief encyclopedic overview with comments on clinical and neurological implications

Translational Research in Anatomy
Background: The first cervical vertebra, the atlas (C1), is a unique and complex structure responsible for supporting the skull and facilitating head movement. Due to its intimate anatomical relationship with the vertebral artery and cervical nerves, any
Robert Haładaj, Roksana Haładaj, Nikola Haładaj, Ivan Varga   +3 more
doaj   +1 more source

Fzd7 Restrains Pink1‐Dependent Mitophagy in Suture Stem Cells to Maintain Cranial Suture Patency

Advanced Science, EarlyView.
How suture stem cells fail to preserve cranial suture patency remains incompletely understood. Integrated single‐cell and high‐resolution spatial transcriptomic analyses identify reduced Fzd7 expression in Prrx1+ suture stem cells as an early feature of craniosynostosis.
Xinyan Chen, Zong Chen, Chenzhi Lai, Yingying Yue, Tian He, Hao Gong, Jing Shi, Xiaoshuang Guo, Yu Wang, Guodong Song, Xiaolei Jin   +10 more
wiley   +1 more source

Transoral unilateral lag screw osteosynthesis for coronal split fracture of the lateral mass of the atlas – case report, operative technique and review of the literature

Brain and Spine, 2023
Introduction: Atlas ring fractures, which account for 1.3% of all spinal fractures, are predominantly managed conservatively. However, in certain cases, surgical treatment may be necessary depending on the type of fracture, degree of comminution ...
Christian Tinner, Fabian Cedric Aregger, Moritz Caspar Deml   +2 more
doaj   +1 more source

Corynoxine Inhibits Tumor Growth via Targeting NQO1 and Modulating the PTPA–NQO1/PP2A Switch to Activate PP2A

Advanced Science, EarlyView.
Corynoxine exerts potent broad‐spectrum anticancer activity by directly targeting NQO1. This interaction dissociates the oncogenic NQO1‐PTPA complex, releasing PTPA to robustly activate the tumor suppressor PP2A. Consequently, downstream Raf/MEK/ERK and PI3K/AKT signaling pathways are suppressed, downregulating c‐Myc and driving tumor regression ...
Guoqing Hou, Li Lin, Mengjie Xia, Ruohan Liang, Yueyue Zhang, Linna Du, Xuan Cao   +6 more
wiley   +1 more source

Research on simulation calculation method of biomechanical characteristics of C1-3 motion segment damage mechanism

Chinese Journal of Contemporary Neurology and Neurosurgery, 2013
Objective To develop the finite element model (FEM) of cervical spinal C1-3 motion segment, and to make biomechanical finite element analysis (FEA) on C1-3 motion segment and thus simulate the biomechanical characteristics of C1-3 motion segment in ...
Ju-ying HUANG, Hai-yun LI, Feng-zeng JIAN, Li-li XU   +3 more
doaj  

Spinabifida of atlas

National Journal of Clinical Anatomy, 2012
During the routine osteology demonstration for the first year MBBS students, the authors came across the presence of incomplete posterior arch in one of the atlas.
K Padmalatha, B S Prakash, N Balachandra, Y Mamatha   +3 more
doaj   +1 more source