Results 91 to 100 of about 1,494,574 (301)

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Exploring the acceptability of two self-sampling devices for human papillomavirus testing in the cervical screening context: a qualitative study of Muslim women in London [PDF]

, 2009
Objectives We explored Muslim women's attitudes to self-sampling for human papillomavirus (HPV) in the context of cervical cancer screening and their responses to two self-sampling devices.Setting A Muslim community centre in north-east London.Methods ...
Cadman, L, Szarewski, A, Ashdown-Barr, L, Waller, J   +3 more
core  

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Cervical cancer screening data from the case-based national electronic registry in Bangladesh

BMC Global and Public Health
Background The Government of Bangladesh established a visual inspection with acetic acid (VIA)-based cervical cancer screening programme at 600 primary, secondary and tertiary health facilities following a pilot programme in 2005.
Ashrafun Nessa, Abul Kalam Azad, Shekh Md. Nizam Uddin, Muhammad Abdul Hannan Khan, Shreshtha Zaman, Mohammad Abdus Salam Khan   +5 more
doaj   +1 more source

The knowledge, Attitude, Practice and Perceived Barriers Towards Screening for Premalignant Cervical Lesions Among Women Aged 18years and Above, in Songea Urban, Ruvuma [PDF]

, 2011
Cervical cancer is the second most common cancer among women worldwide. About 83% of the cases occur in developing countries, representing 15% of female cancers.
John, James
core  

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Testing positive for human papillomavirus in routine cervical screening: examination of psychosocial impact [PDF]

, 2004
Objective To examine the psychosocial impact of testing positive for high risk human papillomavirus (HPV) among women attending primary cervical screening.Design Cross sectional survey.Measures were taken at baseline and one week after the receipt of HPV
Cadman, L, Forrest, S, Szarewski, A, Waller, J, McCaffery, K, Wardle, J   +5 more
core  

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

[Performance by cytology and hybrid capture II in screening for high-grade squamous intraepithelial lesions in women with HIV]. [PDF]

, 2011
HIV-infected women are at increased risk of developing high-grade squamous intraepithelial lesions (HSIL), the precursor lesions for cervical cancer. This study estimated and compared the performance of cytology and hybrid capture II in screening for ...
Andrea Cytryn, Grinsztejn, Beatriz Gilda Jegerhorn, Russomano, Fábio Bastos, Letícia Martins Raposo, Cytryn, Andrea, Velasque, Luciane de Souza, Velasque, Luciane, Raposo, Let??cia Martins, Luz, Paula Mendes, Veloso, Valdil??a Gon??alves, Luciane Velasque, Santos, Valdiléa Gonçalves Veloso dos, Brasil, Pedro EAA, Pedro E. A. A. Brasil, Friedman, Ruth Khalili, Veloso, Valdiléa Gonçalves, Russomano, F??bio Bastos, Angela Cristina Vasconcelos de Andrade, Raposo, Letícia Martins, Vanni, Tazio, Russomano, Fabio, Beatriz Grinsztejn, Cytryn, Andr??a, Struchiner, Claudio José, Ruth Khalili Friedman, Andrade, Angela Cristina Vasconcelos de, Valdiléa Gonçalves Veloso, Claudio José Struchiner, Paula Mendes Luz, Grinsztejn, Beatriz, Fabio Russomano, Tazio Vanni, Brasil, Pedro E. A. A., Struchiner, Claudio Jos??   +33 more
core   +1 more source

Comprehensive Assessment of Arterial, Tissue, and Venous Collaterals for Evaluating the Infarct Growth Rate: The Multimodal Collateral Score

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Collaterals are crucial factors that influence the infarct growth rate (IGR). We aimed to determine whether a comprehensive multimodal collateral score (MCS), incorporating collateral assessment at the arterial, tissue, and venous levels, is associated with functional independence and provides incremental prognostic value over ...
Giorgio Busto, Umberto Pensato, Ilaria Casetta, Giorgio U. Marcello, Angelo Barra, Anna Poggesi, Edoardo Carlesi, Sara Mancini, Andrea Ginestroni, Vittorio Miele, Alessandro Padovani, Andrea Morotti, Enrico Fainardi   +12 more
wiley   +1 more source