Results 81 to 90 of about 1,494,574 (301)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Scalable long-read nanopore HPV16 amplicon-based whole-genome sequencing

Scientific Reports
Human papillomavirus 16 (HPV16) drives precursor cervical lesions that often progress to cervical cancer (CC). Variation within the HPV16 genome has been associated with CC risk.
Maina K. Titus, David Giesbrecht, Cliff I. Oduor, Kapten Muthoka, Karamoko Niaré, Rebecca Crudale, Abebe A. Fola, Sin Ting Hui, Isaac E. Kim, Philip K. Tonui, Peter M. Itsura, Ronald Tonui, Ann M. Moormann, Patrick J. Loehrer, Darron R. Brown, Omenge E. Orang’o, Susan Cu-Uvin, Aaron C. Ermel, Rachel A. Katzenellenbogen, Jeffrey A. Bailey   +19 more
doaj   +1 more source

Clinical Epidemiology of Microinvasive Cervical Carcinoma in an Italian Population Targeted by a Screening Programme

, 2022
SIMPLE SUMMARY: According to this population-based study, 3750 patients living in the Emilia-Romagna Region (northern Italy) were registered with cervical carcinoma between 1995–2016, including 2942 eligible patients.
Lauro Bucchi, Ferretti, Stefano, Falcini, Fabio, Campari, Cinzia, Fabio Falcini, Giorgi Rossi, Paolo, Ravaioli, Alessandra, Alessandra Ravaioli, Vattiato, Rosa, Priscilla Sassoli de Bianchi, Costa, Silvano, Zamagni, Federica, On Behalf Of The Emilia-Romagna Region Workgroup For Cervical Screening Evaluation, null, Silvia Mancini, Orietta Giuliani, Debora Canuti, Mancini, Silvia, Cinzia Campari, Flavia Baldacchini, Giuliani, Orietta, Canuti, Debora, Stefano Ferretti, Sassoli de Bianchi, Priscilla, Federica Zamagni, Bucchi, Lauro, Rosa Vattiato, Silvano Costa, on behalf of the Emilia-Romagna Region Workgroup for Cervical Screening Evaluation on behalf of the Emilia-Romagna Region Workgroup for Cervical Screening Evaluation, Paolo Giorgi Rossi, Baldacchini, Flavia   +29 more
core   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

[Health promotion strategy 2004] / Irish Cervical Screening Programme

, 2004
Irish Cervical Screening ...
Irish Cervical Screening Programme (ICSP)
core  

Anticipated regret to increase uptake of colorectal cancer screening (ARTICS):a randomised controlled trial [PDF]

, 2015
Screening is important for early detection of colorectal cancer. Our aim was to determine whether a simple anticipated regret (AR) intervention could increase uptake of colorectal cancer screening. A randomised controlled trial of a simple, questionnaire-
Brownlee, Linda A., Steele, Robert J. C., O'Carroll, Ronan E., Steele, Robert, Chambers, Julie A., Chambers, Julie, Brownlee, Linda, Libby, Gillian, Steele, Robert J.C., O'Carroll, Ronan   +9 more
core   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Extended HPV genotyping by the BD Onclarity assay: concordance with screening HPV-DNA assays, triage biomarkers, and histopathology in women from the NTCC2 study

Microbiology Spectrum
The use of clinically validated human papillomavirus (HPV) assays is recommended in cervical cancer screening, and extended genotyping is getting attention as a triage biomarker because of the different oncogenic risk of the high-risk HPV genotypes.
Laura De Marco, Simonetta Bisanzi, Guglielmo Ronco, Pamela Mancuso, Francesca Carozzi, Elena Allia, Raffaella Rizzolo, Daniela Gustinucci, Helena Frayle, Jessica Viti, Anna Iossa, Elena Cesarini, Simonetta Bulletti, Basilio Passamonti, Silvia Gori, Laura Toniolo, Francesco Venturelli, Annarosa Del Mistro, Paolo Giorgi Rossi, Maria Benevolo   +19 more
doaj   +1 more source

Evaluation report: Limerick awareness campaign, 6th-18th October 2003 / Fiona Tracey

, 2003
Irish Cervical Screening Programme ...
Irish Cervical Screening Programme (ICSP)
core  

HPV cervical screening from CervicalCheck

, 2023
All women and people with a cervix aged 25-65 are eligible for free HPV cervical screening with CervicalCheck. Cervical screening is a test to identify those at increased risk of developing cancer. It is not a test for cancer.
The National Cervical Screening Programme, Health Service Executive   +1 more
core