Results 51 to 60 of about 50,237 (216)

[Zr-89]Zr-cetuximab PET/CT as biomarker for cetuximab monotherapy in patients with RAS wild-type advanced colorectal cancer [PDF]

, 2020
PURPOSE: One-third of patients with RAS wild-type mCRC do not benefit from anti-EGFR monoclonal antibodies. This might be a result of variable pharmacokinetics and insufficient tumor targeting.
Elias, S.G., van Es, S. C., Dekker, H., Hoekstra, O S, van Herpen, C M L, Oyen, W. J. G., van Helden, E. J., Es, S.C. van, Brouwers, A.H., van Helden, E J, Huisman, M.C., Hoekstra, O.S., Huisman, M C, Verheul, H. M. W., Dongen, G. van, van Es, S C, van Herpen, C. M. L., van Dongen, G A M S, Menke-van der Houven van Oordt, C. W., de Vries, E G E, Menke-van der Houven van Oordt, C W, van Grieken, N. C. T., Oyen, W.J.G., Boellaard, R, Oyen, W J G, van Oordt, C. W. Menke-van der Houven, Vugts, D. J., Herpen, C.M.L. van, Brouwers, A. H.; id_orcid, Elias, S. G., Verheul, H.M.W., Huisman, M. C., van Grieken, N C T, Gerritse, S.L., Menke-van der Houven van Oordt, C.W., Boon, E, Gerritse, S. L., Vries, E.G. de, Gerritse, S L, Vugts, D J, Boon, E., Elias, S G, van Dongen, G. A. M. S., Boellaard, R., Verheul, H M W, de Vries, E. G. E.; id_orcid, Grieken, N.C. van, Helden, E.J. van, Brouwers, A H, Vugts, D.J., Hoekstra, O. S., Dekker, H, Epi Kanker Team A, JC onderzoeksprogramma Cancer, Cancer   +54 more
core   +1 more source

Network meta-analysis and cost-effectiveness analysis comparing Cetuximab-β and Cetuximab for Chinese patients with RAS/BRAF wild-type metastatic colorectal cancer

Frontiers in Pharmacology
BackgroundThe escalating economic burden of metastatic colorectal cancer (mCRC) in China necessitates cost-effective first-line treatments. Cetuximab-β, a newer version of Cetuximab, is approved for first-line RAS/BRAF wild-type mCRC.
Rongjun Tong, Mengyu Yang, Wanjie Zhang, Mengyuan Zhou, Linning Wang, Yun Lu, Feng Chang   +6 more
doaj   +1 more source

Interleukin‐33 as an early predictor of cetuximab treatment efficacy in patients with colorectal cancer

Cancer Medicine, 2021
Background Cetuximab is used for colorectal cancer (CRC) treatment. However, the early biomarker of treatment efficacy of cetuximab has not been identified. Methods After 1 year of cetuximab treatment, patients were divided into an effective group and an
Xujun Zhang, Kefan Bi, Xiaoxuan Tu, Qiong Zhang, Qingyi Cao, Yan Liang, Ping Zeng, Lin Wang, Tianxing Liu, Weijia Fang, Hongyan Diao   +10 more
doaj   +1 more source

Cetuximab-conjugated iron oxide nanoparticles for cancer imaging and therapy [PDF]

, 2015
Shih-Heng Tseng,1,2 Min-Yuan Chou,2 I-Ming Chu1 1Department of Chemical Engineering, National Tsing Hua University, 2Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Hsinchu, Taiwan Abstract: We have ...
Tseng SH, Chu IM, Chou MY
core  

Exosomes promote cetuximab resistance via the PTEN/Akt pathway in colon cancer cells

Brazilian Journal of Medical and Biological Research, 2017
Cetuximab is widely used in patients with metastatic colon cancer expressing wildtype KRAS. However, acquired drug resistance limits its clinical efficacy. Exosomes are nanosized vesicles secreted by various cell types.
S. Zhang, Y. Zhang, J. Qu, X. Che, Y. Fan, K. Hou, T. Guo, G. Deng, N. Song, C. Li, X. Wan, X. Qu, Y. Liu   +12 more
doaj   +1 more source

Click‐Spaltung quartärer Anilinium‐Tetrazine ermöglicht Kaskadenaufbau multifunktioneller biomolekularer Gerüste

Angewandte Chemie, EarlyView.
Die Click‐Chemie hat sich von dem Aufbau kovalenter Bindungen hin zum Spalten von Bindungen weiterentwickelt. Hier wird über einen Kaskaden‐Aufbau berichtet, der diese Verfahren kombiniert, um multifunktionale biomolekulare Gerüste in einer modularen Ein‐Topf‐Reaktion aufzubauen.
Markus Staudt, Christian B. M. Poulie, Andreas Löffler, Peter R. Meinig, Riley J. Deutsch‐Williams, Barbara Herrmann, Ralph Weissleder, Hannes Mikula, Jonathan C. T. Carlson, Matthias M. Herth   +9 more
wiley   +1 more source

A Novel Anti-EGFR mAb Ame55 with Lower Toxicity and Better Efficacy than Cetuximab When Combined with Irinotecan

Journal of Immunology Research, 2019
To improve efficacy and minimize toxicity of EGFR inhibition treatment, we developed Ame55, a novel anti-EGFR IgG1 with lower affinity to EGFR than cetuximab (C225) from a human phage library.
Weiyi Qiu, Chang Zhang, Shuang Wang, Xiaoyan Yu, Qiong Wang, Dadi Zeng, Peng Du, Jinling Ma, Yiqiong Zheng, Bo Pang, Yunzhou Yu, Feng Long, Xiaobin Pang, Zhiwei Sun   +13 more
doaj   +1 more source

Predictive role of UCA1-containing exosomes in cetuximab-resistant colorectal cancer

Cancer Cell International, 2018
Background Primary or acquired resistance to cetuximab often occurs during targeted therapy in metastatic colorectal cancer (mCRC) patients. In many cancers, the key role of the long noncoding RNA (lncRNA) urothelial carcinoma-associated 1 (UCA1) in ...
Ying-nan Yang, Rui Zhang, Jing-wen Du, Heng-heng Yuan, Yan-jing Li, Xiao-li Wei, Xiao-xue Du, Shu-lin Jiang, Yu Han   +8 more
doaj   +1 more source

Expression of neurofibromin 1 in colorectal cancer and cetuximab resistance

, 2021
Neurofibromin 1 (NF1) is a tumor suppressor that has been previously reported to regulate RAS-MAPK signaling. The present study investigated the possible relationship between NF1 expression and anti-EGFR antibody (cetuximab) sensitivity in colorectal ...
Jihun Kim, Yong Sang Hong, Tak, Eunyoung, Eunyoung Tak, Youngra Cho, Buhm Han, Choi, Sueun, Kim, Hyung-Don, Kim, Minhee, Sun Young Kim, Cho, Youngra, Jang, Chloe Soo-Hyun, Chloe Soo-Hyun Jang, Hong, Yong Sang, Minhee Kim, Hyung-Don Kim, Kim, Jeong Eun, Tae Won Kim, Kim, Sun Young, Jeong Eun Kim, Han, Buhm, Kim, Jihun, Kim, Tae Won, Sueun Choi, Sun Kim, Jeong Kim, Chloe Jang, Yong Hong, Tae Kim   +28 more
core   +1 more source

Click‐to‐Release Reactivity of Quaternary Anilinium Tetrazines Enables Cascade Assembly of Multifunctional Biomolecular Scaffolds

Angewandte Chemie International Edition, EarlyView.
Click chemistry has evolved from making covalent connections to also breaking bonds. Here, a cascade assembly is reported that combines these maneuvers to build multifunctional biomolecular scaffolds in a modular one‐pot reaction. The unifying azide release‐tetrazine hub clicks with a trans‐cyclooctene tag, rapidly liberates N,N‐dimethylaniline to ...
Markus Staudt, Christian B. M. Poulie, Andreas Löffler, Peter R. Meinig, Riley J. Deutsch‐Williams, Barbara Herrmann, Ralph Weissleder, Hannes Mikula, Jonathan C. T. Carlson, Matthias M. Herth   +9 more
wiley   +1 more source