Results 81 to 90 of about 50,237 (216)

Contemporary Treatment Patterns in Surgically Treated Temporal Bone Cancer

The Laryngoscope, EarlyView.
In a national cohort of 811 surgically treated temporal bone cancer patients, adjuvant radiation therapy was the most frequently utilized postoperative treatment (20.3%), while chemotherapy and immunotherapy were used far less frequently. Multimodal treatment, particularly combined parotidectomy and neck dissection, was strongly associated with higher ...
Raquel Rowell, Christopher Z. Wen, Vera Bzhilyanskaya, Jane Y. Tong, Adam C. Kaufman   +4 more
wiley   +1 more source

Biodistribution Study of Intravenously Injected Cetuximab-IRDye700DX in Cynomolgus Macaques

, 2016
Purpose: The use of receptor-targeted antibodies conjugated to photosensitizers is actively being explored to enhance treatment efficacy. To facilitate clinical testing, we evaluated cetuximab conjugated to IRDye700DX (IR700) in cynomolgus macaques ...
Rosenthal, E. L., French, D. N., Zinn, K. R., de Boer, E., Warram, J. M., Samuel, S., Schoeb, T. R.   +6 more
core   +1 more source

Chimeric Monoclonal Antibody Cetuximab Targeting Epidermal Growth Factor-Receptor in Advanced Non-Melanoma Skin Cancer [PDF]

, 2017
BACKGROUND: Non-melanoma skin cancer (NMSC) is the most common malignancy in humans. Targeted therapy with monoclonal antibody cetuximab is an option in case of advanced tumor or metastasis.AIM: We present and update of the use of cetuximab in NMSC ...
Uwe Wollina, Torello Lotti, Georgi Tchernev   +2 more
core   +1 more source

Oncologic Outcomes in p16‐Positive Oropharyngeal Squamous Cell Carcinoma With Extranodal Extension

The Laryngoscope, EarlyView.
In this retrospective cohort of 232 surgically treated patients with p16‐positive oropharyngeal squamous cell carcinoma, survival outcomes were high and recurrence rates low. Macroscopic histopathologic extranodal extension (pENE) demonstrated lower 5‐year overall survival compared to microscopic pENE (80.2% vs. 89.8%), although this difference was not
Victoria Taylor, Colin MacKay, S. Mark Taylor, Jonathan Trites, Ayham Al Afif, Adrian Mendez, Matthew H. Rigby   +6 more
wiley   +1 more source

Recent Advances (2023–2025) of Capillary Electrophoresis‐Mass Spectrometry (CE‐MS) for Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Top‐down proteomics (TDP) characterizes proteoforms in cells, tissues, and biofluids, in discovery mode and on a global scale, requiring analytical tools with high peak capacity for proteoform separation and high sensitivity for proteoform detection, given the extremely high proteoform complexity and wide proteoform concentration dynamic range.
Guijie Zhu, David A. Alvarez Rodriguez, Noah Gould, Alexander R. Ivanov, Kevin Jooß, Liangliang Sun   +5 more
wiley   +1 more source

Primary chemoradiation with cisplatin versus cetuximab for locally advanced head and neck cancer: a retrospective cohort study

Experimental Hematology & Oncology, 2020
Objective To explore the efficacy of primary chemoradiation with cisplatin versus cetuximab with respect to HPV/p16 and smoking statuses. Methods We retrospectively reviewed patients from our center with locally advanced non-nasopharyngeal head and neck ...
Il Seok Daniel Jeong, Huan Mo, Anthony Nguyen, Esther G. Chong, Hsin Hsiang Clarence Tsai, Justin Moyers, Matthew Kim, Curtis Lacy, Vivek Shah, Eric Lau, Yi Xu, Huynh Cao   +11 more
doaj   +1 more source

The contribution of cetuximab in the treatment of recurrent and/or metastatic head and neck cancer

, 2010
Mohamedtaki A Tejani, Roger B Cohen, Ranee MehraDepartment of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USAAbstract: Recurrent and/or metastatic squamous cell carcinoma of the head and neck (HNSCC) continues to be a source of
Mohamedtaki A Tejani, Roger B Cohen, Ranee Mehra   +2 more
core  

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Efficacy and Blood Concentrations of Cetuximab in a Hemodialysis Patient with Tongue Squamous Cell Carcinoma: A Case Report

Case Reports in Oncology
Introduction: Cetuximab is an effective therapy for unresectable locoregionally advanced head and neck cancer, but for patients with end-stage renal disease (ESRD), clinical trials seldom provide evidence for the efficacy and safety of ...
Ting-Ting Niu, Wei-Yang Zhang, Ling Han, Hui-Jie Shi, Ying Piao, Li-Wei Ren, Shi-Hai Wu   +6 more
doaj   +1 more source

AI‐Driven Rational Design of Nanotherapeutics for Pancreatic Ductal Adenocarcinoma

Medicinal Research Reviews, EarlyView.
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains a formidable malignancy characterized by late diagnosis, high recurrence rates, and pronounced chemoresistance. While nanoparticle‐based drug delivery systems (NDDS) offer theoretical advantages over conventional therapies, their clinical translation in PDAC has been severely limited.
Seohyun Choo, Kaeun Chae, Jueun Lee, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source