Results 101 to 110 of about 35,110 (216)

Combination RSL3 Treatment Sensitizes Ferroptosis- and EGFR-Inhibition-Resistant HNSCCs to Cetuximab

International Journal of Molecular Sciences, 2022
Head and neck squamous cell carcinomas (HNSCCs) are a type of cancer originating in the mucosal epithelium of the mouth, pharynx, and larynx, the sixth most common cancer in the world. However, there is no effective treatment for HNSCCs. More than 90% of HNSCCs overexpress epidermal growth factor receptors (EGFRs).
Shujie Liu, Shuai Yan, Jie Zhu, Ruiqing Lu, Chujie Kang, Kang Tang, Jinfeng Zeng, Mingmei Ding, Zixiang Guo, Xianxin Lai, Yinan Jiang, Siqing Wu, Lihua Zhou, Litao Sun, Zhong-Wei Zhou   +14 more
openaire   +2 more sources

Oral Squamous Cell Carcinoma‐Risk Factors, Diagnosis, Treatment, and Prevention

Cancer Nexus, EarlyView.
ABSTRACT Oral squamous cell carcinoma (OSCC) usually originates from the precancerous lesions of oral mucosa and accounts for approximately 90% of oral cancers. In‐depth understanding of pathogenesis, hallmarks, and etiological factors is a crucial prerequisite for advancing the diagnosis and treatment for OSCC patients. This review aims to present the
Liping Wang, Xiaole Liu, Mengjie Chen, Ying Hu, Lilei Zhu   +4 more
wiley   +1 more source

Molecular–clinical characteristics and treatment outcomes in 163 metastatic colorectal neuroendocrine carcinomas with a comparison to colorectal adenocarcinomas

International Journal of Cancer, EarlyView.
What's New? Colorectal neuroendocrine carcinoma (CR‐NEC) is a rare digestive neuroendocrine neoplasm that frequently exhibits an adenocarcinoma component. Nonetheless, the underlying biology of CR‐NEC remains poorly understood. This study examined molecular and clinical features and palliative chemotherapy outcomes of metastatic CR‐NEC, with comparison
Siren Morken, Seppo W. Langer, Geir Olav Hjortland, Anna Sundlöv, Eva Hofsli, Morten Ladekarl, Elizaveta Tabaksblat, Lene Weber Vestermark, Johanna Svensson, Ulrich Knigge, Luís Nunes, Bengt Glimelius, Per Pfeiffer, Kristine Aasebø, Jörg Assmus, Erik Vassella, Inger Marie Bowitz Lothe, Anne Couvelard, Aurel Perren, Stian Knappskog, Halfdan Sorbye   +20 more
wiley   +1 more source

miR-196b strictly regulates and reliably predicts the response to cetuximab in colorectal cancer

Cellular & Molecular Biology Letters
Background Cetuximab resistance severely restricts its effectiveness in the treatment of patients with metastatic colorectal cancer (CRC). Previous studies have predominantly focused on the genetic level, with scant attention to the nongenetic aspects ...
Shiyun Chen, Zhaoli Tan, Yanli Lin, Fang Pang, Xiaojie Wu, Xiang Li, Yumeng Cui, Weiling Man, Ying Li, Yanghua Li, Lu Han, Miaomiao Gou, Zhikuan Wang, Guanghai Dai, Youliang Wang   +14 more
doaj   +1 more source

Impact of non‐genetic heterogeneity of BRAF‐mutant colon cancer organoids on growth kinetics, drug sensitivity and Wnt dynamics

International Journal of Cancer, EarlyView.
What's New? Patient‐derived organoids (PDOs) model tumor biology and drug response while preserving key tumor features, yet the impact of non‐genetic culture variables is poorly understood. This study examined the influence of organoid size, seeding density, and morphology on growth, drug sensitivity, and Wnt signaling in a colorectal cancer organoid ...
Viktoria Zieger, Ellen Woehr, Jasmin Traichel, Tilman Brummer, Roland Zengerle, Sabrina Kartmann, Stefan Zimmermann   +6 more
wiley   +1 more source

⁸⁹Zr-DFO-Cetuximab as a Molecular Imaging Agent to Identify Cetuximab Resistance in Head and Neck Squamous Cell Carcinoma [PDF]

Cancer Biotherapy and Radiopharmaceuticals, 2019
Background: Despite the improvement in clinical outcomes for head and neck squamous cell carcinoma (HNSCC) as the result of cetuximab, patients may present with or develop resistance that increases tumor recurrence rates and limits clinical efficacy.
Raquel, Benedetto, Adriana V F, Massicano, Bryant K, Crenshaw, Renato, Oliveira, Rui M, Reis, Elaine B, Araújo, Suzanne E, Lapi   +6 more
openaire   +2 more sources

Radiotherapy and Immune System Interactions Historical Perspectives and Clinical Advancements

Molecular Carcinogenesis, EarlyView.
ABSTRACT Radiotherapy (RT) has evolved significantly since its inception from treating benign conditions to becoming a cornerstone of cancer treatment. This review examines the complex interactions between RT and the immune system, highlighting its diverse effects on various immune cell populations, and exploring emerging strategies to enhance ...
Safiy Yahia, Ayman J. Oweida, Houda Bahig, Daniel Taussky   +3 more
wiley   +1 more source

Primary resistance to cetuximab therapy in EGFR FISH-positive colorectal cancer patients [PDF]

British Journal of Cancer, 2008
The impact of KRAS mutations on cetuximab sensitivity in epidermal growth factor receptor fluorescence in situ hybridisation-positive (EGFR FISH+) metastatic colorectal cancer patients (mCRC) has not been previously investigated. In the present study, we analysed KRAS, BRAF, PI3KCA, MET, and IGF1R in 85 mCRC treated with cetuximab-based therapy in whom
Cappuzzo F., Varella Garcia M., Finocchiaro G., Skokan M., Gajapathy S., Carnaghi C., Rimassa L., Rossi E., Ligorio C., Di Tommaso L., Holmes A. J., Toschi L., TALLINI, GIOVANNI, Destro A., Roncalli M., Santoro A., Jänne P. A.   +16 more
openaire   +2 more sources

Simulation‐Informed Evaluation of Microvascular Parameter Mapping for Diffusion MR Imaging of Solid Tumours

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose We aim to inform the design of new diffusion MRI (dMRI) approaches for microvasculature quantification that enhance the biological specificity of imaging towards cancer. Methods We adopted simulation‐informed modelling of the vascular dMRI signal. We synthesised signals from 1500 synthetic vascular networks, for a variety of protocols (
Anna Kira Voronova, Olivia Prior, Athanasios Grigoriou, Francesc Salvà, Elena Elez, Luz M. Atlagich, Roser Sala‐Llonch, Marco Palombo, Els Fieremans, Dmitry S. Novikov, Raquel Perez‐Lopez, Francesco Grussu   +11 more
wiley   +1 more source

AlphaFold2‐Guided Cyclic Peptide Stabilizer Design to Target Protein–Protein Interactions

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The control and modulation of protein–protein interactions (PPIs) is of central importance for the majority of biological processes and most biomedical applications. Stabilization of PPIs, besides inhibition, is of growing pharmaceutical interest.
Niklas Halbwedl, Martin Zacharias
wiley   +1 more source