Results 141 to 150 of about 35,110 (216)

HOXB8 mediates resistance to cetuximab in colorectal cancer cells through activation of the STAT3 pathway

Discover Oncology
Homeobox B8 (HOXB8) belongs to the HOX family and was essential to the development of colorectal carcinoma. Among the prevalent monoclonal antibodies for treating RAS/BRAF wild-type metastatic colorectal cancer (mCRC) patients, cetuximab stands out, but ...
Yunan Liang, Han Lin, Zongsheng Jiang, Qi Zhao, Ri Cui, Shaotang Li   +5 more
doaj   +1 more source

Theranostic Potential of EFNB2 for Cetuximab Resistance in Head and Neck Cancer. [PDF]

Indian J Otolaryngol Head Neck Surg, 2023
Chaudhary RK, Patil P, Mateti UV, Alagundagi DB, Shetty V.   +4 more
europepmc   +1 more source

Microenvironment plasticity confers cetuximab resistance [PDF]

Nature Reviews Clinical Oncology, 2019
openaire   +2 more sources

Establishment of head and neck squamous cell carcinoma mouse models for cetuximab resistance and sensitivity. [PDF]

Cancer Drug Resist, 2023
Zaryouh H, De Pauw I, Baysal H, Melis J, Van den Bossche V, Hermans C, Lau HW, Lambrechts H, Merlin C, Corbet C, Peeters M, Vermorken JB, De Waele J, Lardon F, Wouters A.   +14 more
europepmc   +1 more source

Combination of cetuximab with met inhibitor in control of cetuximab-resistant oral squamous cell carcinoma.

American journal of translational research
Objective: To investigate the underlying molecular mechanisms contributing to oral squamous cell carcinoma (OSCC) cell resistance to the epidermal growth factor receptor (EGFR) inhibitor. Materials and methods: OSCC cell lines HSC-2 and HSC-3 were assessed in vitro for drug treatment, cell viability, and gene expression and the online gene expression ...
Hua, Yang, Chuzi, Mo, Yang, Xun, Leyna G, Liu, Wenxing, Li, Jieying, Guan, Jing, Liu, Jianquan, Wu, Anping, Yang, Songguo, Zheng, Dahai, Liu, Fang, Liu   +11 more
openaire   +1 more source

3-Bromopyruvate overcomes cetuximab resistance in human colorectal cancer cells by inducing autophagy-dependent ferroptosis. [PDF]

Cancer Gene Ther, 2023
Mu M, Zhang Q, Zhao C, Li X, Chen Z, Sun X, Yu J.   +6 more
europepmc   +1 more source

IGF2BP3 promotes the progression of colorectal cancer and mediates cetuximab resistance by stabilizing EGFR mRNA in an m⁶A-dependent manner. [PDF]

Cell Death Dis, 2023
Chen LJ, Liu HY, Xiao ZY, Qiu T, Zhang D, Zhang LJ, Han FY, Chen GJ, Xu XM, Zhu JH, Ding YQ, Wang SY, Wang SY, Ye YP, Jiao HL.   +14 more
europepmc   +1 more source

Cyclin O promotes lung cancer progression and cetuximab resistance via cell cycle regulation and CDK13 interaction. [PDF]

J Thorac Dis, 2023
Jiang J, Yu W, Fang T, Li Y, Liang J, Zhao R, Feng Z, Wang J, Tian H.   +8 more
europepmc   +1 more source

Genomic Assessment of Blood-Derived Circulating Tumor DNA in Patients With Colorectal Cancers: Correlation With Tissue Sequencing, Therapeutic Response, and Survival. [PDF]

, 2019
PurposeGenomic alterations in blood-derived circulating tumor DNA (ctDNA) from patients with colorectal cancers were correlated with clinical outcomes.Patients and methodsNext-generation sequencing of ctDNA (54- to 73-gene panel) was performed in 94 ...
Fanta, Paul T, Kato, Shumei, Kurzrock, Razelle, Lanman, Richard B, Leichman, Lawrence, Lippman, Scott M, Okamura, Ryosuke, Raymond, Victoria M, Schwaederlé, Maria C, Talasaz, AmirAli   +9 more
core   +1 more source

PPARα-mediated lipid metabolism reprogramming supports anti-EGFR therapy resistance in head and neck squamous cell carcinoma

Nature Communications
Anti-epidermal growth factor receptor (EGFR) therapy (cetuximab) shows a limited clinical benefit for patients with locally advanced or recurrent/metastatic head and neck squamous cell carcinoma (HNSCC), due to the frequent occurrence of secondary ...
Valentin Van den bossche, Julie Vignau, Engy Vigneron, Isabella Rizzi, Hannah Zaryouh, An Wouters, Jérôme Ambroise, Steven Van Laere, Simon Beyaert, Raphaël Helaers, Cédric van Marcke, Lionel Mignion, Elise Y. Lepicard, Bénédicte F. Jordan, Céline Guilbaud, Olivier Lowyck, Hajar Dahou, Antonella Mendola, Manon Desgres, Léo Aubert, Isabelle Gerin, Guido T. Bommer, Romain Boidot, Perrine Vermonden, Aurélien Warnant, Yvan Larondelle, Jean-Pascal Machiels, Olivier Feron, Sandra Schmitz, Cyril Corbet   +29 more
doaj   +1 more source