Results 101 to 110 of about 71,270 (242)
Exome sequencing of Saudi Arabian patients with ADPKD
Renal Failure, 2019 Purpose: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive development of kidney cysts and enlargement and dysfunction of the kidneys. The Consortium of Radiologic Imaging Studies of the Polycystic Kidney Disease (CRISP)
Fahad A. Al-Muhanna +19 more
doaj +1 more source
Eternal Black Holes and Superselection in AdS/CFT [PDF]
, 2012 It has been argued i) that Lorentz-signature solutions with wormholes connecting n asymptotically AdS regions describe bulk quantum states dual to n entangled but non-interacting CFTs and ii) that such bulk wormhole states should be identified with ...
Marolf, Donald, Wall, Aron C.
core +2 more sources
Medicinal Research Reviews, EarlyView.ABSTRACT To enhance drug discovery efforts, medicinal chemists should evaluate, filter, and utilize relevant structural information about target proteins. Acquiring and interpreting protein structures is crucial for elucidating ligand‐receptor interactions and addressing ADME‐related considerations, making it an essential aspect of medicinal chemistry.
Matteo Rossi Sebastiano +4 more
wiley +1 more source
, 2004 We propose a framework for the implementation of a subtraction formalism at NNLO in QCD, based on an observable- and process-independent cancellation of infrared singularities. As a first simple application, we present the calculation of the contribution
C. Anastasiou +15 more
core +1 more source
Nutrition in Clinical Practice, EarlyView.Abstract Background In individuals with cystic fibrosis (CF), lean mass and muscle strength are important predictors of clinical outcomes. This study evaluated associations among body composition, handgrip strength, muscle quality, physical activity, and health‐related quality of life in CF. Methods This observational, cross‐sectional study included 27
Benjamin H. Crain +9 more
wiley +1 more source
Ontogeny of purinergic receptor-regulated Ca2+ signaling in mouse cortical collecting duct epithelium [PDF]
, 2002 Changes in ATP-induced increase in {[}Ca2+], during collecting duct ontogeny were studied in primary monolayer cultures of mouse ureteric bud (UB) and cortical collecting duct (CCD) cells by Fura-PE3 fluorescence ratio imaging.
Borscheid, R. +4 more
core +1 more source
Respirology, EarlyView.ABSTRACT Chronic obstructive pulmonary disease (COPD) remains the third leading cause of death worldwide, and conventional bronchodilator‐based therapies have limited efficacy in preventing exacerbations and disease progression. The 2024–2026 period represents a historic inflection point: three mechanistically distinct agents received Food and Drug ...
Naoya Fujino, Hisatoshi Sugiura
wiley +1 more source
Two-loop QCD Corrections to the Heavy Quark Form Factors: the Vector Contributions
, 2004 We present closed analytic expressions of the electromagnetic vertex form factors for heavy quarks at the two-loop level in QCD for arbitrary momentum transfer. The calculation is carried out in dimensional regularization.
't Hooft +63 more
core +1 more source
Mechanisms of CFTR Functional Variants That Impair Regulated Bicarbonate Permeation and Increase Risk for Pancreatitis but Not for Cystic Fibrosis [PDF]
, 2014 CFTR is a dynamically regulated anion channel. Intracellular WNK1-SPAK activation causes CFTR to change permeability and conductance characteristics from a chloride-preferring to bicarbonate-preferring channel through unknown mechanisms.
Alkaade, Samer +26 more
core +4 more sources
Slow Transit Constipation: Pathophysiological Perspectives and Management Updates
Journal of Digestive Diseases, EarlyView.Slow transit constipation (STC) is a complex neuromuscular disorder driven by interstitial cells of Cajal (ICCs) loss and enteric neuropathy. Diagnosis relies on objective transit testing while excluding pelvic floor dysfunction. Management follows a stepwise, phenotype‐driven approach, progressing from conventional laxatives to emerging targeted ...
Athanasios Syllaios +8 more
wiley +1 more source