Results 201 to 210 of about 1,231,622 (330)
Cystic Fibrosis: Treatment with CFTR Modulators
, 2023 CFTR modulators have been a groundbreaking new invention starting with the approval of the CFTR corrector Ivacaftor in 2012. Nowadays, up to 90% of CF patients have the potential ability to get treated by an appropriate CFTR modulator. Ivacaftor showed significant improvement in the treatment of CF patients with gating mutations, especially in G551D ...
openaire +2 more sources
Clinical Transplantation, Volume 40, Issue 1, January 2026.ABSTRACT Background: In pediatric lung transplantation, the ability to estimate the projected waiting time could be particularly helpful for candidates and physicians. A score to predict waiting time has yet to be developed in this field. The purpose of this study was to create a score that predicts waitlist time for pediatric patients who are listed ...
Jose Ramirez +2 more
wiley +1 more source
Increased aminotransferases do not necessarily mean hepatotoxicity of CFTR modulator therapy. [PDF]
Clin Exp Hepatol, 2023 Woynarowski M +3 more
europepmc +1 more source
TDP‐43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models
The FEBS Journal, Volume 293, Issue 2, Page 348-384, January 2026.The manuscript explores structural and functional features of TDP‐43 and its worm homologue, TDP‐1, highlighting conserved and divergent structural and functional features. Using genetically engineered C. elegans models, key pathological features of TDP‐43 proteinopathies—including aggregation, neurodegeneration, and motor deficits—are recapitulated ...
Ghulam Jeelani Pir +7 more
wiley +1 more source
The PROSPECT Is Bright for CFTR Modulators
Annals of the American Thoracic Society, 2021 Kristina Montemayor, Noah Lechtzin
openaire +2 more sources
Welfare Indicators for Aquaculture Research: Toolboxes for Five Farmed European Fish Species
Reviews in Aquaculture, Volume 18, Issue 1, January 2026.ABSTRACT Refining approaches to measuring, monitoring and appraising animal welfare in aquaculture research is key to (i) protecting and optimizing it, (ii) documenting the severity of how and when it deviates, and (iii) ensuring good scientific quality, reliable results and reproducibility, amongst other factors.
Chris Noble +50 more
wiley +1 more source
Regulation of acetylcholine release from guinea-pig bladder urothelial cells - potential role in bladder filling sensations [PDF]
, 2014 Fry, C. H. +2 more
core +1 more source
Time Course of Changes in Peripheral Blood Gene Expression During Medication Treatment for Major Depressive Disorder. [PDF]
, 2019 Changes in gene expression (GE) during antidepressant treatment may increase understanding of the action of antidepressant medications and serve as biomarkers of efficacy.
Congdon, Eliza +6 more
core +1 more source