Results 141 to 150 of about 1,208,918 (256)
PIEZO Force Sensing in Vascular Biology: An Explosion of New Knowledge, Concepts and Opportunity
Advanced Science, Volume 12, Issue 41, November 6, 2025.Knowledge of the remarkable mechanical force sensing and electrically transducing PIEZO1 and PIEZO2 channels is discussed across vascular biology and its cell types from the embryonic to adult stages in health, disease and old age. How the channels work, relate to other factors and signal for tissue responses to mechanical forces is debated.
David J Beech
wiley +1 more source
302 Clinical response to modulator therapy in patients homozygous for G27V CFTR
, 2023 J. Brewington +9 more
openalex +1 more source
Nitrogen Scavengers: History, Clinical Considerations and Future Prospects
Journal of Inherited Metabolic Disease, Volume 48, Issue 6, November 2025.ABSTRACT Nitrogen scavengers play a critical role in treating acute and chronic hyperammonemia, especially in urea cycle disorders (UCDs), where impaired ammonia detoxification leads to toxic nitrogen accumulation. These agents complement low‐protein diets and urea cycle intermediates.
Sven Klassa, Johannes Häberle
wiley +1 more source
Recent advances in vasoactive intestinal peptide physiology and pathophysiology: focus on the gastrointestinal system. [PDF]
, 2019 Vasoactive intestinal peptide (VIP), a gut peptide hormone originally reported as a vasodilator in 1970, has multiple physiological and pathological effects on development, growth, and the control of neuronal, epithelial, and endocrine cell functions ...
Akiba, Yasutada +2 more
core
PLoS Genetics, 2018 CFTR modulators have revolutionized the treatment of individuals with cystic fibrosis (CF) by improving the function of existing protein. Unfortunately, almost half of the disease-causing variants in CFTR are predicted to introduce premature termination ...
Neeraj Sharma +18 more
doaj +1 more source
Pediatric Pulmonology, Volume 60, Issue 11, November 2025.ABSTRACT Background During the coronavirus disease 2019 (COVID19) pandemic, restrictions on in‐person care threatened to disrupt in‐clinic airway sampling for microbiological surveillance, a vital aspect of cystic fibrosis (CF) care. In response, institutions developed home airway sampling strategies to allow continued guidelines‐based microbiological ...
Valerie Swanston +4 more
wiley +1 more source
Collaboration between two conserved sequence motifs drives ATPase stimulation of Hsp90 by Aha1
Protein Science, Volume 34, Issue 11, November 2025.Abstract Hsp90 is a dimeric molecular chaperone essential for the folding, stabilization, activation, and maturation of hundreds of client proteins, which are critical for cellular function. Co‐chaperones, such as Aha1, play a key role in regulating the ATP‐dependent Hsp90 client activation cycle by modulating Hsp90's ATPase activity and controlling ...
Desmond Prah Amoah +4 more
wiley +1 more source
Precision Medicine Based on CFTR Genotype for People with Cystic Fibrosis
Pharmacogenomics and Personalized Medicine, 2022 Iram Haq,1,2 Maryam Almulhem,1 Simone Soars,1 David Poulton,2,3 Malcolm Brodlie1,2 1Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK; 2Paediatric Respiratory Medicine, Great North ...
Haq I +4 more
doaj