Results 321 to 330 of about 45,269 (354)
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Science Signaling
The DNA double-strand break sensor MRE11 is necessary to liberate cGAS and enable its activation by dsDNA.
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The DNA double-strand break sensor MRE11 is necessary to liberate cGAS and enable its activation by dsDNA.
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Nature Reviews Molecular Cell Biology, 2018
Cyclic GMP–AMP synthase (cGAS) inhibits DNA damage repair in the nucleus and thereby promotes tumorigenesis.
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Cyclic GMP–AMP synthase (cGAS) inhibits DNA damage repair in the nucleus and thereby promotes tumorigenesis.
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Science-Business eXchange, 2013
University of Texas Southwestern Medical Center researchers have confirmed the role of cyclic GMP-AMP signaling in the innate immune system, making a case for developing adjuvants that agonize the pathway or antagonists of the pathway to treat autoimmune conditions.
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University of Texas Southwestern Medical Center researchers have confirmed the role of cyclic GMP-AMP signaling in the innate immune system, making a case for developing adjuvants that agonize the pathway or antagonists of the pathway to treat autoimmune conditions.
openaire +1 more source
The cGAS–STING pathway as a therapeutic target in inflammatory diseases
Nature Reviews Immunology, 2021Alexiane Decout, Andrea Ablasser
exaly
cGAS–STING drives ageing-related inflammation and neurodegeneration
Nature, 2023Muhammet Gulen, Marius Schwabenland
exaly
cGAS–STING drives the IL-6-dependent survival of chromosomally instable cancers
Nature, 2022Michael Schubert +2 more
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