Results 101 to 110 of about 148,798 (282)

Studies of the Molecular Mechanism of Discrimination between cGMP and cAMP in the Allosteric Sites of the cGMP-binding cGMP-specific Phosphodiesterase (PDE5) [PDF]

Journal of Biological Chemistry, 1999
The regulatory domain of the cGMP-binding cGMP-specific 3':5'-cyclic nucleotide phosphodiesterase (PDE5) contains two homologous segments of amino acid sequence that encode allosteric cyclic nucleotide-binding sites, referred to as site a and site b, which are highly selective for cGMP over cAMP.
Sharron H. Francis, Jackie D. Corbin, Illarion V. Turko   +2 more
openaire   +3 more sources

Mechanisms of Action and Targets of Nitric Oxide in the Oculomotor System [PDF]

, 1998
Nitric oxide (NO) production by neurons in the prepositus hypoglossi (PH) nucleus is necessary for the normal performance of eye movements in alert animals.
Escudero González, Miguel, Estrada Cerquera, Carmen, Moreno López, Bernardo   +2 more
core   +1 more source

Nitric Oxide-Independent cGMP Efflux in the Striatum of Rats Exposed to Carbon Monoxide as Determined by Microdialysis

Journal of Pharmacological Sciences, 2007
Extracellular cGMP in the striatum of rats exposed to 3000 ppm carbon monoxide (CO) or 8% O2 was decreased during the early period of exposure. Thereafter, extracellular cGMP in rats exposed to CO, but not 8% O2, was transiently increased. A nitric oxide
Shuichi Hara, Toshiji Mukai, Hajime Mizukami, Fumi Kuriiwa, Takashi Watanabe, Takahiko Endo   +5 more
doaj  

Cyclic Guanosine Monophosphate and Risk of Incident Heart Failure and Other Cardiovascular Events: the ARIC Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Cyclic guanosine monophosphate (cGMP) is a second messenger regulated through natriuretic peptide and nitric oxide pathways. Stimulation of cGMP signaling is a potential therapeutic strategy for heart failure with preserved ejection fraction ...
Di Zhao, Eliseo Guallar, Dhananjay Vaidya, Chiadi E. Ndumele, Pamela Ouyang, Wendy S. Post, Joao A. Lima, Wendy Ying, David A. Kass, Ron C. Hoogeveen, Sanjiv J. Shah, Vinita Subramanya, Erin D. Michos   +12 more
doaj   +1 more source

cGMP-Dependent Protein Kinase Contributes to Hydrogen Sulfide-Stimulated Vasorelaxation

PLoS ONE, 2012
A growing body of evidence suggests that hydrogen sulfide (H2S) is a signaling molecule in mammalian cells. In the cardiovascular system, H2S enhances vasodilation and angiogenesis.
M. Bucci, A. Papapetropoulos, V. Vellecco, Zongmin Zhou, Altaany Zaid, P. Giannogonas, Anna Cantalupo, Sandeep Dhayade, K. Karalis, Rui Wang, R. Feil, G. Cirino   +11 more
semanticscholar   +1 more source

Identification of murine phosphodiesterase 5A isoforms and their functional characterization in HL-1 cardiac cell line [PDF]

, 2017
Phosphodiesterase 5A (PDE5A) specifically degrades the ubiquitous second messenger cGMP and experimental and clinical data highlight its important role in cardiac diseases.
Barbagallo, Federica, Campolo, Federica, Cardarelli, Silvia, Cornacchione, Marisa, DE ARCANGELIS, Valeria, DI GRAZIA, Antonio, Gianfrilli, Daniele, Giorgi, Mauro, Isidori, Andrea, Lenzi, Andrea, Monaco, Lucia, Naro, Fabio, Pellegrini, Manuela, Zevini, Alessandra   +13 more
core   +1 more source

Effects of casein glycomacropeptide supplementation on growth performance, intestinal morphology, intestinal barrier permeability and inflammatory responses in Escherichia coli K88 challenged piglets

Animal Nutrition, 2015
Casein glycomacropeptide (CGMP) is a bioactive peptide derived from milk with multiple functions. This study was aimed at evaluating the effects of CGMP as a potential feed additive on growth performance, intestinal morphology, intestinal barrier ...
Yili Rong, Zeqing Lu, Haiwen Zhang, Lin Zhang, Deguang Song, Yizhen Wang   +5 more
doaj   +1 more source

Purified anthocyanin supplementation improves endothelial function via NO-cGMP activation in hypercholesterolemic individuals.

Clinical Chemistry, 2011
BACKGROUND Anthocyanins have been shown to improve endothelial function in animal models. However, whether these compounds have similar beneficial effects in humans is largely unknown.
Yanna Zhu, M. Xia, Yan Yang, Feng-qiong Liu, Zhongxia Li, Y. Hao, M. Mi, T. Jin, W. Ling   +8 more
semanticscholar   +1 more source

Guanylyl cyclase activation reverses resistive breathing–induced lung injury and inflammation [PDF]

, 2015
Inspiratory resistive breathing (RB), encountered in obstructive lung diseases, induces lung injury. The soluble guanylyl cyclase (sGC)/cyclic guanosine monophosphate (cGMP) pathway is down-regulated in chronic and acute animal models of RB, such as ...
Brouckaert, Peter, Dettoraki, Maria, Giannis, Athanassios, Glynos, Constantinos, Karavana, Vassiliki, Kotsikoris, Vasilis, Loverdos, Konstantinos, Magkou, Christina, Papapetropoulos, Andreas, Pavlidou, Athanasia, Perlikos, Fotis, Theocharis, Stamatios E, Topouzis, Stavros, Toumpanakis, Dimitris, Vassilakopoulos, Theodoros, Zhou, Zongmin   +15 more
core   +2 more sources

An Overgrowth Disorder Associated with Excessive Production of cGMP Due to a Gain-of-Function Mutation of the Natriuretic Peptide Receptor 2 Gene

PLoS ONE, 2012
We describe a three-generation family with tall stature, scoliosis and macrodactyly of the great toes and a heterozygous p.Val883Met mutation in Npr2, the gene that encodes the CNP receptor NPR2 (natriuretic peptide receptor 2). When expressed in HEK293A
Kohji Miura, N. Namba, M. Fujiwara, Y. Ohata, H. Ishida, T. Kitaoka, T. Kubota, H. Hirai, C. Higuchi, N. Tsumaki, H. Yoshikawa, N. Sakai, T. Michigami, K. Ozono   +13 more
semanticscholar   +1 more source