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Erratum in: Calcitonin Gene-Related Peptide Regulates Specific Interferon-Stimulating Genes to Inhibit Apoptosis of Corneal Epithelial Cells in Dry Eye Disease. [PDF]
Invest Ophthalmol Vis Scieuropepmc +1 more source
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Salivary CGRP and Erenumab Treatment Response: Towards Precision Medicine in Migraine
Annals of Neurology, 2022We aimed (1) to analyze salivary calcitonin gene‐related peptide (CGRP) levels in patients with migraine, (2) to predict erenumab response from baseline CGRP levels, and (3) to evaluate CGRP change post‐treatment.
A. Alpuente +5 more
semanticscholar +1 more source
Recognizing the role of CGRP and CGRP receptors in migraine and its treatment
Cephalalgia, 2019PremiseThe brain and the sensory nervous system contain a rich supply of calcitonin gene-related peptide (CGRP) and CGRP receptor components. Clinical studies have demonstrated a correlation between CGRP release and acute migraine headache that led to the development of CGRP-specific drugs that either abort acute attacks of migraine (gepants) or are ...
L. Edvinsson, K. Warfvinge
semanticscholar +5 more sources
Cephalalgia, 2021
Introduction and objective Monoclonal antibodies targeting the calcitonin gene-related peptide pathway (anti-CGRP mAbs) have shown promising efficacy in randomised clinical trials for the prevention of episodic and chronic migraine, but no head-to-head ...
Konstantina Drellia +4 more
semanticscholar +1 more source
Introduction and objective Monoclonal antibodies targeting the calcitonin gene-related peptide pathway (anti-CGRP mAbs) have shown promising efficacy in randomised clinical trials for the prevention of episodic and chronic migraine, but no head-to-head ...
Konstantina Drellia +4 more
semanticscholar +1 more source
CGRP antagonists: unravelling the role of CGRP in migraine
Trends in Pharmacological Sciences, 2007Migraine is a complex, debilitating neurovascular disorder. Although knowledge on the main molecular players is still incomplete, recent preclinical and clinical findings indicate that there is a clear correlation between migraine-associated headache and the release of the neuropeptide calcitonin gene-related peptide (CGRP). BIBN4096 was the first CGRP
Stefan Just +3 more
openaire +3 more sources
Handbook of Experimental Pharmacology, 2019
Migraine is a common neurological disorder that afflicts up to 15% of the adult population in most countries, with predominance in females. It is characterized by episodic, often disabling headache, photophobia and phonophobia, autonomic symptoms (nausea and vomiting), and in a subgroup an aura in the beginning of the attack.
L. Edvinsson
semanticscholar +5 more sources
Migraine is a common neurological disorder that afflicts up to 15% of the adult population in most countries, with predominance in females. It is characterized by episodic, often disabling headache, photophobia and phonophobia, autonomic symptoms (nausea and vomiting), and in a subgroup an aura in the beginning of the attack.
L. Edvinsson
semanticscholar +5 more sources
Pain pharmacology in migraine: focus on CGRP and CGRP receptors
Neurological Sciences, 2007Over the last 100 years, the discovery of new analgesics has been a complex and difficult task. However, remarkable progress in the identification of novel molecular targets relevant for pain medicines has been reported. Here we will focus on the neuropeptide calcitonin generelated peptide (CGRP) and its receptors (CGRP-R) because of their role in ...
BENEMEI, SILVIA +3 more
openaire +4 more sources