Results 271 to 280 of about 43,468 (306)
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2012
Receptor activity modifying protein 1 (RAMP1) forms a complex with calcitonin receptor-like receptor (CLR) to produce the receptor for calcitonin gene-related peptide (CGRP). RAMP1 has two main roles. It facilitates the cell-surface expression of CLR. It is also essential for the binding of CGRP to the receptor.
James, Barwell +4 more
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Receptor activity modifying protein 1 (RAMP1) forms a complex with calcitonin receptor-like receptor (CLR) to produce the receptor for calcitonin gene-related peptide (CGRP). RAMP1 has two main roles. It facilitates the cell-surface expression of CLR. It is also essential for the binding of CGRP to the receptor.
James, Barwell +4 more
openaire +2 more sources
Headache, 2018
Objective – To briefly describe the history of and available data on anti‐calcitonin gene‐related peptide (CGRP) therapies for headache.
S. Tepper
semanticscholar +1 more source
Objective – To briefly describe the history of and available data on anti‐calcitonin gene‐related peptide (CGRP) therapies for headache.
S. Tepper
semanticscholar +1 more source
CGRP antagonist activity of short fragments of human αCGRP, CGRP(23–37) and CGRP(19–37)
Peptides, 1992The activity of short C-terminal fragments of human alpha calcitonin gene-related peptide (CGRP), CGRP(19-37), and CGRP(23-37), and of the N-terminally acetylated (Ac) derivative, AcCGRP(19-37), has been investigated in the guinea pig isolated left atria (electrically driven) for their ability to antagonize the positive inotropic effect of human alpha ...
ROVERO, PAOLO, S. Giuliani, C. A. Maggi
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Hormonal influences in migraine — interactions of oestrogen, oxytocin and CGRP
Nature Reviews Neurology, 2021D. Krause +3 more
semanticscholar +1 more source
Neurology, 2011
Calcitonin gene-related peptide (CGRP) is a vasodilator neuropeptide that is expressed in a subgroup of small neurons in the dorsal root ganglion (DRG), trigeminal, and vagal ganglia, which respond to noxious, thermal, or visceral input. These peptidergic neurons use l-glutamate as their primary neurotransmitter and project to the dorsal horn ...
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Calcitonin gene-related peptide (CGRP) is a vasodilator neuropeptide that is expressed in a subgroup of small neurons in the dorsal root ganglion (DRG), trigeminal, and vagal ganglia, which respond to noxious, thermal, or visceral input. These peptidergic neurons use l-glutamate as their primary neurotransmitter and project to the dorsal horn ...
openaire +2 more sources
Targeting CGRP for the Prevention of Migraine and Cluster Headache: A Narrative Review
Headache, 2019Calcitonin‐gene‐related peptide (CGRP), a neuropeptide broadly distributed in neuronal and non‐neuronal regions throughout the body, plays a fundamental role in migraine and cluster headache (CH) pathophysiology.
Hsiangkuo Yuan +2 more
semanticscholar +1 more source
CGRP receptor antagonists (gepants)
Small molecule calcitonin gene-related peptide (CGRP) receptor antagonists are commonly referred to as gepants. The first generation of gepants provided the first line of evidence of CGRP-mediated antimigraine medication in 2004-2011. However, further development was halted due to either lack of oral availability or concerns of hepatotoxicity.Samaira, Younis +3 more
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CGRP Receptor Signalling Pathways
2018Calcitonin gene-related peptide (CGRP) is a promiscuous peptide, similar to many other members of the calcitonin family of peptides. The potential of CGRP to act on many different receptors with differing affinities and efficacies makes deciphering the signalling from the CGRP receptor a challenging task for researchers.Although it is not a typical G ...
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Peptides, 1993
The activity of short C-terminal fragments of human alpha calcitonin gene-related peptide (CGRP), CGRP(19-37), and CGRP(23-37), and of the N-terminally acetylated (Ac) derivative, AcCGRP(19-37), has been investigated in the guinea pig isolated left atria (electrically driven) for their ability to antagonize the positive inotropic effect of human alpha ...
ROVERO, PAOLO, S. Giuliani, C. A. Maggi
openaire +2 more sources
The activity of short C-terminal fragments of human alpha calcitonin gene-related peptide (CGRP), CGRP(19-37), and CGRP(23-37), and of the N-terminally acetylated (Ac) derivative, AcCGRP(19-37), has been investigated in the guinea pig isolated left atria (electrically driven) for their ability to antagonize the positive inotropic effect of human alpha ...
ROVERO, PAOLO, S. Giuliani, C. A. Maggi
openaire +2 more sources