Results 281 to 290 of about 42,233 (316)

Distribution of CGRP and CGRP receptor components in the rat brain

Cephalalgia, 2017
Background Calcitonin gene-related peptide and its receptor, consisting of receptor activity-modifying protein 1 and calcitonin receptor-like receptor, are of considerable interest because of the role they play in migraine and recently developed migraine therapies.
Karin Warfvinge, Karin Warfvinge, Lars Edvinsson   +2 more
openaire   +4 more sources

The activation of the CGRP receptor

Biochemical Society Transactions, 2013
The CGRP (calcitonin gene-related peptide) receptor is a family B GPCR (G-protein-coupled receptor). It consists of a GPCR, CLR (calcitonin receptor-like receptor) and an accessory protein, RAMP1 (receptor activity modifying protein 1). RAMP1 is needed for CGRP binding and also cell-surface expression of CLR.
Barwell, James, Wheatley, Mark, Conner, Alex C, Taddese, Bruck, Vohra, Shabana, Reynolds, Christopher A, Poyner, David R   +6 more
openaire   +4 more sources

CGRP receptors: beyond the CGRP1–CGRP2 subdivision?

Trends in Pharmacological Sciences, 2001
In a recent TiPS article 1xThe molecular pharmacology of CGRP and related peptide receptor subtypes. Juaneda, C. et al. Trends Pharmacol. Sci. 2000; 21: 432–438Abstract | Full Text | Full Text PDF | PubMed | Scopus (131)See all References1, Juaneda and colleagues reviewed the molecular pharmacology of calcitonin gene-related peptide (CGRP) and related ...
David R. Poyner, Ian W. Marshall
openaire   +3 more sources

CGRP Discovery and Timeline

2018
Calcitonin gene-related peptide (CGRP) was discovered over about 35 years ago through molecular biological techniques. Its activity as a vasodilator and the proposal that it was involved in pain processing were then soon established. Today, we are in the interesting situation of having the approval for the clinical use of antagonists and antibodies ...
Arkless, Kate, Argunhan, Fulye, Brain, Susan D.   +2 more
openaire   +4 more sources

Serotonin, NO, and CGRP and Headache

Headache: The Journal of Head and Face Pain, 2011
Objective.-Identification of the neural mechanisms underlying medication overuse headache resulting from triptans. Methods.-Triptans were administered systemically to rats by repeated intermittent injections or by continuous infusion over 6 days. Periorbital and hind paw sensory thresholds were measured to detect cutaneous allodynia.
MaassenVanDenBrink, A., Ferrari, M.D.
openaire   +4 more sources

RAMPs and CGRP Receptors

2012
Receptor activity modifying protein 1 (RAMP1) forms a complex with calcitonin receptor-like receptor (CLR) to produce the receptor for calcitonin gene-related peptide (CGRP). RAMP1 has two main roles. It facilitates the cell-surface expression of CLR. It is also essential for the binding of CGRP to the receptor.
Denise Wootten, Debbie L. Hay, John Simms, David R. Poyner, James Barwell   +4 more
openaire   +3 more sources

CGRP Immunoreactivity in the Mammalian Pancreasa

Annals of the New York Academy of Sciences, 1992
not ...
Howard A. Reber, Catia Sternini, Vay Liang W. Go, F. C. Brunicardi, F. C. Brunicardi, R. De Giorgio, R. De Giorgio, A. L. Widdison   +7 more
openaire   +4 more sources

Blocking the CGRP Pathway for Acute and Preventative Treatment of Migraine - The Evolution of Success.

Journal of Medicinal Chemistry, 2020
The pivotal role of calcitonin gene-related peptide (CGRP) in migraine pathophysiology was identified over 30 years ago, but the successful clinical development of targeted therapies has only recently been realized.
G. Dubowchik, Charles M. Conway, Alison W. Xin   +2 more
semanticscholar   +1 more source

CGRP antagonist activity of short fragments of human αCGRP, CGRP(23–37) and CGRP(19–37)

Peptides, 1992
The activity of short C-terminal fragments of human alpha calcitonin gene-related peptide (CGRP), CGRP(19-37), and CGRP(23-37), and of the N-terminally acetylated (Ac) derivative, AcCGRP(19-37), has been investigated in the guinea pig isolated left atria (electrically driven) for their ability to antagonize the positive inotropic effect of human alpha ...
ROVERO, PAOLO, S. Giuliani, C. A. Maggi
openaire   +2 more sources

Molecular studies of CGRP and the CGRP family of peptides in the central nervous system

Cephalalgia, 2018
BackgroundCalcitonin gene-related peptide is an important target for migraine and other painful neurovascular conditions. Understanding the normal biological functions of calcitonin gene-related peptide is critical to understand the mechanisms of calcitonin gene-related peptide-blocking therapies as well as engineering improvements to these medications.
Erica R Hendrikse, Rebekah L Bower, Debbie L Hay, Christopher S Walker   +3 more
openaire   +3 more sources