Results 281 to 290 of about 50,213 (312)
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Headache Currents, 2004
Neuronal Expression and Regulation of CGRP Promoter Activity Following Viral Gene Transfer into Cultured Trigeminal Ganglia Neurons We examined the regulation of calcitonin gene‐related peptide (CGRP) promoter activity in primary cultures of rat trigeminal ganglia neurons.
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Neuronal Expression and Regulation of CGRP Promoter Activity Following Viral Gene Transfer into Cultured Trigeminal Ganglia Neurons We examined the regulation of calcitonin gene‐related peptide (CGRP) promoter activity in primary cultures of rat trigeminal ganglia neurons.
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2018
Calcitonin gene-related peptide (CGRP) was discovered over about 35 years ago through molecular biological techniques. Its activity as a vasodilator and the proposal that it was involved in pain processing were then soon established. Today, we are in the interesting situation of having the approval for the clinical use of antagonists and antibodies ...
Arkless, Kate +2 more
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Calcitonin gene-related peptide (CGRP) was discovered over about 35 years ago through molecular biological techniques. Its activity as a vasodilator and the proposal that it was involved in pain processing were then soon established. Today, we are in the interesting situation of having the approval for the clinical use of antagonists and antibodies ...
Arkless, Kate +2 more
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Distribution of CGRP and CGRP receptor components in the rat brain
Cephalalgia, 2017Background Calcitonin gene-related peptide and its receptor, consisting of receptor activity-modifying protein 1 and calcitonin receptor-like receptor, are of considerable interest because of the role they play in migraine and recently developed migraine therapies.
Warfvinge, Karin, Edvinsson, Lars
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2012
Receptor activity modifying protein 1 (RAMP1) forms a complex with calcitonin receptor-like receptor (CLR) to produce the receptor for calcitonin gene-related peptide (CGRP). RAMP1 has two main roles. It facilitates the cell-surface expression of CLR. It is also essential for the binding of CGRP to the receptor.
James, Barwell +4 more
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Receptor activity modifying protein 1 (RAMP1) forms a complex with calcitonin receptor-like receptor (CLR) to produce the receptor for calcitonin gene-related peptide (CGRP). RAMP1 has two main roles. It facilitates the cell-surface expression of CLR. It is also essential for the binding of CGRP to the receptor.
James, Barwell +4 more
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CGRP antagonist activity of short fragments of human αCGRP, CGRP(23–37) and CGRP(19–37)
Peptides, 1992The activity of short C-terminal fragments of human alpha calcitonin gene-related peptide (CGRP), CGRP(19-37), and CGRP(23-37), and of the N-terminally acetylated (Ac) derivative, AcCGRP(19-37), has been investigated in the guinea pig isolated left atria (electrically driven) for their ability to antagonize the positive inotropic effect of human alpha ...
ROVERO, PAOLO, S. Giuliani, C. A. Maggi
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Neurology, 2011
Calcitonin gene-related peptide (CGRP) is a vasodilator neuropeptide that is expressed in a subgroup of small neurons in the dorsal root ganglion (DRG), trigeminal, and vagal ganglia, which respond to noxious, thermal, or visceral input. These peptidergic neurons use l-glutamate as their primary neurotransmitter and project to the dorsal horn ...
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Calcitonin gene-related peptide (CGRP) is a vasodilator neuropeptide that is expressed in a subgroup of small neurons in the dorsal root ganglion (DRG), trigeminal, and vagal ganglia, which respond to noxious, thermal, or visceral input. These peptidergic neurons use l-glutamate as their primary neurotransmitter and project to the dorsal horn ...
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CGRP receptor antagonists (gepants)
Small molecule calcitonin gene-related peptide (CGRP) receptor antagonists are commonly referred to as gepants. The first generation of gepants provided the first line of evidence of CGRP-mediated antimigraine medication in 2004-2011. However, further development was halted due to either lack of oral availability or concerns of hepatotoxicity.Samaira, Younis +3 more
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CGRP Receptor Signalling Pathways
2018Calcitonin gene-related peptide (CGRP) is a promiscuous peptide, similar to many other members of the calcitonin family of peptides. The potential of CGRP to act on many different receptors with differing affinities and efficacies makes deciphering the signalling from the CGRP receptor a challenging task for researchers.Although it is not a typical G ...
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Peptides, 1993
The activity of short C-terminal fragments of human alpha calcitonin gene-related peptide (CGRP), CGRP(19-37), and CGRP(23-37), and of the N-terminally acetylated (Ac) derivative, AcCGRP(19-37), has been investigated in the guinea pig isolated left atria (electrically driven) for their ability to antagonize the positive inotropic effect of human alpha ...
ROVERO, PAOLO, S. Giuliani, C. A. Maggi
openaire +2 more sources
The activity of short C-terminal fragments of human alpha calcitonin gene-related peptide (CGRP), CGRP(19-37), and CGRP(23-37), and of the N-terminally acetylated (Ac) derivative, AcCGRP(19-37), has been investigated in the guinea pig isolated left atria (electrically driven) for their ability to antagonize the positive inotropic effect of human alpha ...
ROVERO, PAOLO, S. Giuliani, C. A. Maggi
openaire +2 more sources