Results 291 to 300 of about 42,233 (316)
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Headache: The Journal of Head and Face Pain, 2017
The calcitonin gene‐related peptide (CGRP) neuropeptide system is an important but still evolving target for migraine. A fundamental consideration for all of the current drugs in clinical trials and for ongoing development in this area is the identity, expression pattern, and function of CGRP receptors because this knowledge informs safety and efficacy
Debbie L. Hay, Christopher S. Walker
openaire +3 more sources
The calcitonin gene‐related peptide (CGRP) neuropeptide system is an important but still evolving target for migraine. A fundamental consideration for all of the current drugs in clinical trials and for ongoing development in this area is the identity, expression pattern, and function of CGRP receptors because this knowledge informs safety and efficacy
Debbie L. Hay, Christopher S. Walker
openaire +3 more sources
Headache, 2020
The monoclonal antibodies against calcitonin gene‐related peptide (CGRP) or its receptor are new antimigraine drugs from which many patients already benefit.
Katrine Falkenberg +2 more
semanticscholar +1 more source
The monoclonal antibodies against calcitonin gene‐related peptide (CGRP) or its receptor are new antimigraine drugs from which many patients already benefit.
Katrine Falkenberg +2 more
semanticscholar +1 more source
Headache, 2018
Objective – To briefly describe the history of and available data on anti‐calcitonin gene‐related peptide (CGRP) therapies for headache.
S. Tepper
semanticscholar +1 more source
Objective – To briefly describe the history of and available data on anti‐calcitonin gene‐related peptide (CGRP) therapies for headache.
S. Tepper
semanticscholar +1 more source
Mapping of CGRP in the alpaca diencephalon
Journal of Chemical Neuroanatomy, 2012We report the distribution of immunoreactive cell bodies and fibers containing calcitonin gene-related peptide in the alpaca diencephalon. This study was carried out in alpacas that lived from birth to death at 0 m above sea level. Immunoreactive fibers were widely distributed throughout the thalamus and hypothalamus. A moderate density of these fibers
Coveñas, R. +6 more
openaire +3 more sources
2019
Migraine is three times more prevalent in women than in men. The mechanisms behind the sex disparity in migraine are not completely understood, but it is thought to be mediated through changes in ovarian steroid hormones. Migraine pathophysiology is considered to involve an activation of the trigeminovascular system and the subsequent release of ...
Rubio-Beltrán, Eloísa +1 more
openaire +2 more sources
Migraine is three times more prevalent in women than in men. The mechanisms behind the sex disparity in migraine are not completely understood, but it is thought to be mediated through changes in ovarian steroid hormones. Migraine pathophysiology is considered to involve an activation of the trigeminovascular system and the subsequent release of ...
Rubio-Beltrán, Eloísa +1 more
openaire +2 more sources
Targeting CGRP for the Prevention of Migraine and Cluster Headache: A Narrative Review
Headache, 2019Calcitonin‐gene‐related peptide (CGRP), a neuropeptide broadly distributed in neuronal and non‐neuronal regions throughout the body, plays a fundamental role in migraine and cluster headache (CH) pathophysiology.
Hsiangkuo Yuan +2 more
semanticscholar +1 more source
Hormonal influences in migraine — interactions of oestrogen, oxytocin and CGRP
Nature Reviews Neurology, 2021D. Krause +3 more
semanticscholar +1 more source
Distribution of CGRP in the minipig brainstem
Microscopy Research and Technique, 2014ABSTRACTFor the first time, an in‐depth study has been made of the distribution of fibers and cell bodies containing calcitonin gene‐related peptide (CGRP) in the minipig brainstem using an indirect immunoperoxidase technique. The animals studied were not treated with colchicine.
Rafael Coveñas +2 more
openaire +3 more sources
Understanding CGRP and Cardiovascular Risk
2019Increasing knowledge about the role of calcitonin gene-related peptide (CGRP) in migraine pathophysiology has led to the development of antibodies against this peptide or its receptor. However, CGRP is widely expressed throughout the body, participating not only in pathophysiological conditions but also in several physiological processes and ...
Eloísa Rubio-Beltrán +1 more
openaire +4 more sources
CGRP as the target of new migraine therapies — successful translation from bench to clinic
Nature Reviews Neurology, 2018L. Edvinsson +3 more
semanticscholar +1 more source