Results 101 to 110 of about 3,615 (181)

Mecanismes de control negatiu de la inflamació vehiculats per receptors nuclears [PDF]

, 2014
Els receptors nuclears són una família de factors de transcripció dependents de lligand que regulen la reproducció, el desenvolupament, el metabolisme i la resposta immunitària.
Matalonga Borrel, Jonathan, Valledor, Annabel F.   +1 more
core  

Mycobacterial trehalose dimycolate reprograms macrophage global gene expression and activates matrix metalloproteinases. [PDF]

, 2013
Trehalose 6,6′-dimycolate (TDM) is a cell wall glycolipid and an important virulence factor of mycobacteria. In order to study the role of TDM in the innate immune response to Mycobacterium tuberculosis, microarray analysis was used to examine gene ...
Actor, B. A. McCormick, Barkan, Barmina, Behling, Bekierkunst, Bekierkunst, Bekierkunst, Belisle, Bowdish, Chang, Chen, Chiu, Clark, Court, d'Ortho, Dannenberg, David G. Russell, Dutta, Elass, Elizabeth R. Rhoades, Elkington, Elkington, Flynn, Fu, Geisel, Granger, Grassi, Guillemard, Hamasaki, Harth, Harth, Heitmann, Helen C. Wainwright, Henriet, Hoheisel, Hrabec, Hunter, Ishikawa, Kaneda, Kaori Sakamoto, Keller, Kierszenbaum, Kim, Kyle H. Rohde, Lai, Liu, Madonna, Masihi, Mi Jeong Kim, Nagase, Nagase, Nan, Nilsson, Park, Parks, Perez, Quiding-Jarbrink, Rachel E. Allavena, Rao, Rao, Retzinger, Rhoades, Rhoades, Rivera-Marrero, Ryan, Sabine Ehrt, Saito, Saito, Sarkar, Schoenen, Shen, Shi, Shi, Silva, Takayama, Taylor, Van Wart, Visse, Volkman, Windish, Wipke, Witmer, Woessner, World Health Organization, Yarkoni   +85 more
core   +2 more sources

Fish Cholesterol 25-Hydroxylase Inhibits Virus Replication via Regulating Interferon Immune Response or Affecting Virus Entry

Frontiers in Immunology, 2019
Cholesterol 25-hydroxylase (CH25H) is an interferon (IFN)-induced gene that catalyzes the oxidation of cholesterol to 25-hydroxycholesterol (25HC), which exerts broad-spectrum antiviral function.
Ya Zhang, Liqun Wang, Liqun Wang, Xiaohong Huang, Shaowen Wang, Youhua Huang, Qiwei Qin, Qiwei Qin   +7 more
doaj   +1 more source

TREM2 sustains microglial expansion during aging and response to demyelination [PDF]

, 2015
Microglia contribute to development, homeostasis, and immunity of the CNS. Like other tissue-resident macrophage populations, microglia express the surface receptor triggering receptor expressed on myeloid cells 2 (TREM2), which binds polyanions, such as
Colonna, Marco, Fontana, Elena, Gilfillan, Susan, Poliani, Pietro Luigi, Robinette, Michelle L, Wang, Yaming, Yamanishi, Yoshinori   +6 more
core   +1 more source

Comprehensive Dissection of PDGF-PDGFR Signaling Pathways in PDGFR Genetically Defined Cells [PDF]

, 2011
Despite the growing understanding of PDGF signaling, studies of PDGF function have encountered two major obstacles: the functional redundancy of PDGFRα and PDGFRβ in vitro and their distinct roles in vivo.
Berger, Bonnie, Galdzicki, Michal, Kohane, Isaac Samuel, Moseman, Annie P., Palmer, Nathan, Tian, Ze, Wang, Xuetao, Wu, Erxi, Zhang, Hongbing   +8 more
core   +1 more source

Lipid homeostasis and inflammatory activation are disturbed in classically activated macrophages with peroxisomal β-oxidation deficiency [PDF]

, 2017
Macrophage activation is characterized by pronounced metabolic adaptation. Classically activated macrophages show decreased rates of mitochondrial fatty acid oxidation and oxidative phosphorylation and acquire a glycolytic state together with their pro ...
Baes, Myriam, De Schryver, Evelyn, Geric, Ivana, Kagan, Valerian E, Krysko, Dmitri, Krysko, Olga, Tyurina, Yulia Y, Van Veldhoven, Paul P, Verheijden, Simon   +8 more
core   +2 more sources

Nutrient sensing, signal transduction and immune responses [PDF]

, 2016
Most cells in the body have a constant supply of nutrients, which are required to sustain cellular metabolism and functions. In contrast, cells of the immune system can encounter conditions with a limited nutrient supply during the course of an immune ...
Alvarez-Curto, Alvarez-Curto, Ananieva, Ananieva, Andersen, Arpaia, Atarashi, Bah, Balmer, Bar-Peled, Bauman, Benhamed, Bensinger, Bertolotti, Bharadwaj, Blagih, Bond, Briscoe, Brown, Brown, Carr, Chang, Chang, Chang, Chantranupong, Chen, Chou, Cobbold, Cui, Cummins, David Finlay, Delgoffe, Delgoffe, Diczfalusy, Donnelly, Donohoe, Fallarino, Feng, Fossati, Furusawa, Garcia-Navas, Glozak, Gold, Golks, Gonzalez, Grallert, Grebe, Hannedouche, Harig, Hart, Hart, Hayashi, Heine, Hirayama, Ho, Hockel, Hong, Horton, Hou, Hu, Huang, Ichimura, Im, Jabara, Jessica Walls, Kanai, Keil, Kidani, Kim, Kneass, Kneass, Le Poul, Linda Sinclair, Liu, Liu, Liu, Maciejewski-Lenoir, Macintyre, MacIver, Maianski, Mangalam, Maslowski, Mayer, Mukhopadhyay, Munger, Munn, Murakami, Nakaya, Nath, Nicklin, Noman, O'Neill, Oh, Orsini, Pallett, Piccoli, Pollizzi, Powell, Preston, Radhakrishnan, Ramakrishnan, Ravindran, Ravindran, Rawson, Rebsamen, Ripoli, Rodriguez, Rodriguez-Espinosa, Rolf, Rose, Ryu, Santori, Schaub, Scheppach, Sheedy, Sinclair, Singh, Smith, Soroosh, Spann, Steffensen, Su, Suzuki, Swamy, Talukdar, Tamune, Tang, Tarhda, Taylor, Thai, Thangaraju, Tremaroli, Urasaki, van Baren, Verbist, Vinolo, Vitko, Wang, Wang, Wang, Wang, Wang, Weichhart, Wolfson, Xing, Xu, Yan, Yang, Yang, York, York, Yu, Zeng, Zhong   +153 more
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Cholesterol 25‐Hydroxylase Protects Against Diabetic Kidney Disease by Regulating ADP Ribosylation Factor 4

Advanced Science
Cholesterol 25‐hydroxylase (CH25H), an enzyme involved in cholesterol metabolism, regulates inflammatory responses and lipid metabolism. However, its role in kidney disease is not known.
Lu Zhang, Zhengying Fang, Qingqing Zhu, Shumin Yang, Jia Fu, Zeguo Sun, Geming Lu, Chengguo Wei, Zhi Zhang, Kyung Lee, Yifei Zhong, Ruijie Liu, John Cijiang He   +12 more
doaj   +1 more source

Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy [PDF]

Alzheimer\u27s disease (AD) is characterized by amyloid plaques and neurofibrillary tangles, in addition to neuroinflammation and changes in brain lipid metabolism.
Cashikar, Anil G, Han, Xianlin, Holtzman, David M, Long, Justin M, Paul, Steven M, Strickland, Michael R, Toral-Rios, Danira, Ulrich, Jason D, Yu, Jinsheng   +8 more
core   +2 more sources

25-hydroxycholesterol aggravates oxygen-glucose deprivation/reoxygenation-induced pyroptosis through promoting activation of NLRP3 inflammasome in H9C2 cardiomyocytes

Brazilian Journal of Medical and Biological Research
25-hydroxycholesterol (25-HC) plays a role in the regulation of cell survival and immunity. However, the effect of 25-HC on myocardial ischemia/reperfusion (MI/R) injury remains unknown.
Tao Jiang, Yong Li
doaj   +1 more source