Results 161 to 170 of about 3,615 (181)

The CH25H–CYP7B1–RORα axis of cholesterol metabolism regulates osteoarthritis

Nature, 2019
Osteoarthritis-the most common form of age-related degenerative whole-joint disease1-is primarily characterized by cartilage destruction, as well as by synovial inflammation, osteophyte formation and subchondral bone remodelling2,3. However, the molecular mechanisms that underlie the pathogenesis of osteoarthritis are largely unknown.
Wan-Su, Choi, Gyuseok, Lee, Won-Hyun, Song, Jeong-Tae, Koh, Jiye, Yang, Ji-Sun, Kwak, Hyo-Eun, Kim, Seul Ki, Kim, Young-Ok, Son, Hojung, Nam, Iljung, Jin, Zee-Yong, Park, Jiyeon, Kim, In Young, Park, Jeong-Im, Hong, Hyun Ah, Kim, Churl-Hong, Chun, Je-Hwang, Ryu, Jang-Soo, Chun   +18 more
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RETRACTED: KLF4/Ch25h axis activated by metformin suppresses EndoMT in human umbilical vein endothelial cells

Biochemical and Biophysical Research Communications, 2020
This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the authors. The authors found that the experiment to show that HG decreased CD31 (Figure 1 E) and increased Vimentin (Figure 1 F) mRNA level could not be repeated ...
Beixin, Yu, Yingying, Wu, Zhao, Li
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ATF3 and CH25H regulate effector trogocytosis and anti-tumor activities of endogenous and immunotherapeutic cytotoxic T lymphocytes

Cell Metabolism, 2022
Effector trogocytosis between malignant cells and tumor-specific cytotoxic T lymphocytes (CTLs) contributes to immune evasion through antigen loss on target cells and fratricide of antigen-experienced CTLs by other CTLs. The mechanisms regulating these events in tumors remain poorly understood.
Zhen Lu, Noreen McBrearty, Jinyun Chen, Vivek S. Tomar, Hongru Zhang, Gianluca De Rosa, Aiwen Tan, Aalim M. Weljie, Daniel P. Beiting, Zhen Miao, Subin S. George, Allison Berger, Gurpanna Saggu, J. Alan Diehl, Constantinos Koumenis, Serge Y. Fuchs   +15 more
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Association studies of cholesterol metabolism genes (CH25H, ABCA1 and CH24H) in Alzheimer's disease

Neuroscience Letters, 2006
Recent studies have demonstrated that cholesterol metabolism has an important role in Alzheimer's disease (AD) pathogenesis, suggesting that cholesterol-related genes may be significant genetic risk factors for AD. Based on the results of genome-wide screens, along with biological studies, we selected three genes as candidates for AD risk factors: ATP ...
Nobuto, Shibata, Toshitaka, Kawarai, Joseph H, Lee, Hye-Seung, Lee, Eri, Shibata, Christine, Sato, Yan, Liang, Rajan, Duara, Richard P, Mayeux, Peter H, St George-Hyslop, Ekaterina, Rogaeva   +10 more
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Travaux préalables à l’investigation fonctionnelle de la cholestérol-25-hydroxylase (CH25H)

2023
La sénescence cellulaire demeure à ce jour un phénomène fort méconnu, mais jouerait un rôle crucial dans le développement de nombreuses pathologies telles que la dégénérescence maculaire reliée à l’âge, la maladie d’Alzheimer et le cancer. De plus, dans le cadre de travaux antérieurs, il a été démontré que la cholestérol-25-hydroxylase (CH25H) est l’un
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The combination of machine learning and untargeted metabolomics identifies the lipid metabolism -related gene CH25H as a potential biomarker in asthma

Inflammation Research, 2023
Lipids, significant signaling molecules, regulate a multitude of cellular responses and biological pathways in asthma which are closely associated with disease onset and progression. However, the characteristic lipid genes and metabolites in asthma remain to be explored.
Xuexuan, Ding, Jingtong, Qin, Fangfang, Huang, Fuhai, Feng, Lianxiang, Luo   +4 more
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A Novel Hybrid of Telmisartan and Borneol Ameliorates Neuroinflammation and White Matter Injury in Ischemic Stroke Through ATF3/CH25H Axis

Translational Stroke Research, 2022
Cerebral ischemic stroke causes substantial white matter injury, which is further aggravated by neuroinflammation mediated by microglia/astrocytes. Given the anti-neuroinflammatory action of telmisartan and the enhancing blood-brain barrier (BBB) permeability potential of resuscitation-inducing aromatic herbs, 13 hybrids (3a-m) of telmisartan (or its ...
Xin, Guan, Jianbing, Wu, Jiahui, Geng, Duorui, Ji, Dasha, Wei, Yong, Ling, Yihua, Zhang, Guojun, Jiang, Tao, Pang, Zhangjian, Huang   +9 more
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Herpes simplex virus type 1 abrogates the antiviral activity of Ch25h via its virion host shutoff protein

Antiviral Research, 2017
Cholesterol 25-hydroxylase (Ch25h) is an interferon-inducible protein, and recent studies have demonstrated that it inhibited the replication of many enveloped viruses. However, in this study, we found that cells infected with wild-type (WT) HSV-1 reduced the expression of Ch25h, and ectopic expression of Ch25h could not inhibit the replication of WT ...
Hongjuan, You, Hui, Yuan, Wenkun, Fu, Chenhe, Su, Wei, Wang, Tong, Cheng, Chunfu, Zheng   +6 more
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LINC01915 Facilitates the Conversion of Normal Fibroblasts into Cancer-Associated Fibroblasts Induced by Colorectal Cancer-Derived Extracellular Vesicles through the miR-92a-3p/KLF4/CH25H Axis

ACS Biomaterials Science & Engineering, 2021
Increasing long non-coding RNAs are reported to regulate the cell growth, apoptosis, and metastasis of cancer-associated fibroblasts (CAFs).This study aimed to explore how LINC01915 influences the conversion of normal fibroblasts (NFs) into CAFs in colorectal cancer (CRC).
Minghe Zhou, Shalong Wang, Dongcai Liu, Jiapeng Zhou   +3 more
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Systemic inflammation modulates the levels of EBI2 and 7α,25-OHC synthesizing (CH25H, CYP7B1) and degrading (HSD3B7) enzymes in brain microvascular cells

2023
ABSTRACTThe endogenous ligand for the EBI2 receptor, oxysterol 7α,25OHC, crucial for immune responses, is finely regulated by CH25H, CYP7B1 and HSD3B7 enzymes. Lymphoid stromal cells and follicular dendritic cells within T cell follicles maintain a gradient of 7α,25OHC, with stromal cells increasing and dendritic cells decreasing its concentration ...
Fionä Caratis, Bartosz Karaszewski, Ilona Klejbor, Tomomi Furihata, Aleksandra Rutkowska   +4 more
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