Results 81 to 90 of about 5,271,658 (210)

The ecology and genetics of Chagas disease vectors in Ecuador, with emphasis on Rhodnius ecuadoriensis (Hemiptera : Reduviidae : Triatominae) [PDF]

An estimate >11 million people are infected by Trypanosoma cruzi in Latin America. Chagas disease control programmes have been successful in the Southern Cone countries, and similar initiatives are underway in the Andean ...
Abad-Franch, Fernando
core   +1 more source

Spatio-temporal trends in mortality due to Chagas disease in the State of Bahia, Brazil, from 2008 to 2018 [PDF]

Revista da Sociedade Brasileira de Medicina Tropical
Background: Chagas disease is a silent illness with high mortality burden in many Latin American countries, such as Brazil. Bahia has the fourth highest mortality rate in Brazil.
Cristiane Medeiros Moraes de Carvalho, Gilmar Ribeiro-Jr, Rodrigo Gurgel-Gonçalves, Liane Santiago Andrade, Cicílio Alves Moraes, Maria Aparecida Araújo Figueiredo   +5 more
doaj   +1 more source

Periodontitis and Inflammatory Bowel Diseases: Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This review aims to provide a conceptual framework for understanding the mechanistic interplay between periodontitis and IBD, with a particular emphasis on the microbial and immunological crosstalk linking the oral cavity and the gastrointestinal tract.
Ana Paula V. Colombo, Adriana M. de Oliveira, Nobuhiko Kamada, Sho Kitamoto   +3 more
wiley   +1 more source

Origins of Chagas disease: Didelphis species are natural hosts of Trypanosoma cruzi I and armadillos hosts of Trypanosoma cruzi II, including hybrids.

, 2005
Trypanosoma cruzi, the causative agent of Chagas disease, has at least two principal intraspecific subdivisions, T. cruzi I (TCI) and T. cruzi II (TCII), the latter containing up to five subgroups (a-e).
González, N., Arias, A. R.de, de Arias, Antonieta Rojas, Acosta, Nidia, González, Nilsa, Miles, M.A., Miles, G.A.J., Patterson, J.S., Sánchez, Humberto, Yeo, M., Patterson, James S, Acosta, N., Sánchez, H., Miles, Graham AJ, Yeo, Matthew, López, Elsa, Miles, Michael A, Gaunt, M.W., López, E., Adamson, Susie, Adamson, S., Gaunt, Michael W, Llewellyn, Martin, Llewellyn, M.S.   +23 more
core   +1 more source

21-Hydroxylase gene mutant allele CYP21A2∗15 strongly linked to the resistant HLA haplotype B∗14:02-DRB1∗01:02 in chronic Chagas disease [PDF]

, 2013
We previously reported protective haplotype HLA-B*14:02-DRB1*01:02 against chronic Chagas disease in Bolivia. The V281L mutant allele of the 21-Hydroxylase gene, CYP21A2*15, is reported to be located in the Class III region of the Human leukocyte antigen
Gianella, Alberto, del Puerto, Florencia, Kikuchi, Mihoko, Roca, Yelin, Gutierrez, Velarde Freddy Udalrico, Lora, Javier, Gutierrez Velarde, Freddy Udalrico, Hirayama, Kenji, Nishizawa, Juan Eiki, del, Puerto Florencia, Avila, Cinthia   +10 more
core   +1 more source

Type IV‐Dominated Plasmid‐Encoded CRISPR‐Cas Systems Are Enriched in Multireplicon and Multi‐Stressor Resistance Plasmids Across the Global Plasmidome

Molecular Microbiology, EarlyView.
Screening 72,555 plasmid sequences reveals that intact CRISPR‐Cas systems are rare (1.03%) but strongly enriched in multireplicon and multi‐stressor resistance plasmids, with Type IV‐A as the dominant subtype. These findings implicate plasmid‐encoded CRISPR‐Cas as non‐randomly retained elements of structurally complex and high‐risk backbones.
Hannay Crystynah Almeida de Souza, Anamaria Mota Pereira dos Santos, Arlen Carvalho de Oliveira Almeida, Carlos Adam Conte Junior, Pedro Panzenhagen   +4 more
wiley   +1 more source

The Global fight against Chagas disease [PDF]

Chagas disease is caused by the parasite Trypanosoma cruzi and is spread by infected triatomine bugs. It can cause serious heart and gastrointestinal problems.7 million living with Chagas in the AmericasThe parasite that causes Chagas disease is found ...

core  

Synthesis, Antiparasitic Activity, and ADME Profile of Morpholinephenylbenzamides: A Pharmacological Study Against Chagas Disease and Visceral Leishmaniasis [PDF]

ChemMedChem
Hit‐to‐lead optimization of morpholinephenylbenzamides reveals key structure–activity relationships against Trypanosoma cruzi and Leishmania infantum. Potency, selectivity, and ADME properties are differentially improved across the series, identifying compounds 20, 24, and 16 as complementary templates for the future design of dual antiparasitic leads.
Farago D, de Melo Resende D, de Moura Lodi Cruz M, Sousa R, Chelucci R, Michelan‐Duarte S, da Silva Mendonça de Melo F, da Silva Oliveira D, Macruz P, dos Santos Carvalho A, Pilau E, Bastos I, Andricopulo A, Ferreira L, Murta S, de Oliveira Rezende Júnior C.   +15 more
europepmc   +2 more sources

High prevalence of a host‐associated Anaplasma lineage in wild coatis (Nasua nasua) from the Brazilian Atlantic Forest

Medical and Veterinary Entomology, EarlyView.
Anaplasma sp. DNA was detected in 47.9% of free‐ranging coatis (Nasua nasua) sampled in Iguaçu National Park, southern Brazil. Molecular analyses revealed a genetically distinct Anaplasma lineage infecting coatis, differing from Anaplasma strains detected in associated tick populations.
Matheus Dias Cordeiro, Paulo César Magalhães‐Matos, Isadora dos Santos Dias, Jônathan David Ribas Chagas, Olívia Zen Gianfrancisco, Ellen Meireles Brandão, Claudia Bezerra da Silva, Bruna de Azevedo Baêta   +7 more
wiley   +1 more source

Chronic Chagas cardiomyopathy: a review of the main pathogenic mechanisms and the efficacy of aetiological treatment following the BENznidazole Evaluation for Interrupting Trypanosomiasis (BENEFIT) trial

Memorias do Instituto Oswaldo Cruz
Chagas cardiomyopathy is the most frequent and most severe manifestation of chronic Chagas disease, and is one of the leading causes of morbidity and death in Latin America.
Anis Rassi Jr, José Antonio Marin Neto, Anis Rassi   +2 more
doaj   +1 more source