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Chagas disease [PDF]

The Lancet
Chagas disease persists as a global public health problem due to the high morbidity and mortality burden. Despite the possibility of a cure and advances in transmission control, epidemiological transformations, such as urbanisation and globalisation, and the emerging importance of oral and vertical transmission mean that Chagas disease should be ...
Andréa Silvestre, de Sousa, Debbie, Vermeij, Alberto Novaes, Ramos, Alejandro O, Luquetti   +3 more
europepmc   +5 more sources

Chagas' disease [PDF]

Clinical Microbiology Reviews, 1992
Chagas' disease, caused by Trypanosoma cruzi, is an important cause of morbidity in many countries in Latin America. The important modes of transmission are by the bite of the reduviid bug and blood transfusion. The organism exists in three morphological forms: trypomastigotes, amastigotes, and epimastigotes.
H B, Tanowitz, L V, Kirchhoff, D, Simon, S A, Morris, L M, Weiss, M, Wittner   +5 more
openaire   +4 more sources

In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi. [PDF]

, 2010
BackgroundCruzain, the major cysteine protease of Trypanosoma cruzi, is an essential enzyme for the parasite life cycle and has been validated as a viable target to treat Chagas' disease.
Brinen, Linda S, Chen, Yen Ting, Doyle, Patricia S, Hansell, Elizabeth, Kerr, Iain D, McKerrow, James H, Roush, William R   +6 more
core   +48 more sources

Biomarkers and Echocardiographic Predictors of Cardiovascular Outcome in Patients With Chronic Chagas Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Chagas disease (CD) presents an ominous prognosis. The predictive value of biomarkers and new echocardiogram parameters in adjusted models have not been well studied.
Veronica G. Mendes, Lorena Rimolo, Ana Carolina B. de Lima, Roberto R. Ferreira, Luciano S. Oliveira, Lindice M. Nisimura, Samuel I. M. Horita, Andréa R. Costa, Gilberto Marcelo S. da Silva, Luiz Henrique C. Sangenis, Fernanda S. N. S. Mendes, Andrea S. Sousa, Henrique H. Veloso, Marcelo T. Holanda, Mauro F. F. Mediano, Mariana C. Waghabi, Luciana R. Garzoni, Otacílio C. Moreira, Constança Britto, Ademir B. Cunha, Alejandro Marcel Hasslocher‐Moreno, Roberto M. Saraiva   +21 more
doaj   +1 more source

Chagas Disease [PDF]

Pediatrics In Review, 2016
Approximately 8 million people worldwide are infected by the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease. After a latent period that can last years or decades, 10% to 30% of infected people develop serious complications, such as cardiomyopathy or gastrointestinal dysfunction.
Tustin, Aaron W., Bowman, Natalie M.
openaire   +2 more sources

Overdiagnosis of vaccine allergy: Skin testing and challenge at a public specialized unit (CRIE) in Rio de Janeiro, Brazil

Journal of Allergy and Clinical Immunology: Global, 2023
Background: Vaccination is an extremely safe public health intervention, but rare IgE-mediated adverse events must be identified to avoid the risk of anaphylaxis in the event of reexposure.
Luciana Gomes Pedro Brandão, PhD, MSc, MD, Mari Tuyama, PhD, MSc, MD, Flávio de Carvalho, MSc, RN, Ananza Taina da Silva Santos, MSc, RN, Alberto dos Santos de Lemos, MSc, MD, Marcellus Dias da Costa, MSc, MD, Emersom Cicilini Mesquita, PhD, MSc, MD, José Cerbino-Neto, PhD, MSc, MD, Margareth Catoia Varela, MSc, Pedro Emmanuel Alvarenga Americano do Brasil, PhD, MSc, MD, Angélica Varela Rondon, MSc, MD   +10 more
doaj   +1 more source

Benznidazole decreases the risk of chronic Chagas disease progression and cardiovascular events: A long-term follow up study

EClinicalMedicine, 2021
Background: Chagas disease (CD) remains an important endemic disease in Latin America. However, CD became globalized in recent decades. The majority of the chronically infected individuals did not receive etiologic treatment for several reasons, among ...
Alejandro M. Hasslocher-Moreno, Roberto M. Saraiva, Luiz H.C. Sangenis, Sergio S. Xavier, Andrea S. de Sousa, Andrea R. Costa, Marcelo T. de Holanda, Henrique H. Veloso, Fernanda S.N.S. Mendes, Filipe A.C. Costa, Marcio N. Boia, Pedro E.A.A. Brasil, Fernanda M. Carneiro, Gilberto M.Sperandio da Silva, Mauro F.F. Mediano   +14 more
doaj   +1 more source

Stroke in Chagas disease: from pathophysiology to clinical practice [PDF]

Revista da Sociedade Brasileira de Medicina Tropical, 2022
Despite substantial progress toward its control, Chagas disease continues to be a major public health problem in Latin America and has become a global health concern.
Thaís Aparecida Reis Lage, Julia Teixeira Tupinambás, Lucas Bretas de Pádua, Matheus de Oliveira Ferreira, Amanda Cambraia Ferreira, Antonio Lucio Teixeira, Maria Carmo Pereira Nunes   +6 more
doaj   +1 more source

Progression Rate from the Indeterminate Form to the Cardiac Form in Patients with Chronic Chagas Disease: Twenty-Two-Year Follow-Up in a Brazilian Urban Cohort

Tropical Medicine and Infectious Disease, 2020
Most patients with chronic Chagas disease (CD) present the indeterminate form and are at risk to develop the cardiac form. However, the actual rate of progression to the cardiac form is still unknown.
Alejandro Marcel Hasslocher-Moreno, Sergio Salles Xavier, Roberto Magalhães Saraiva, Luiz Henrique Conde Sangenis, Marcelo Teixeira de Holanda, Henrique Horta Veloso, Andrea Rodrigues da Costa, Fernanda de Souza Nogueira Sardinha Mendes, Pedro Emmanuel Alvarenga Americano do Brasil, Gilberto Marcelo Sperandio da Silva, Mauro Felippe Felix Mediano, Andrea Silvestre de Sousa   +11 more
doaj   +1 more source

Mixed infection by Cryptococcus neoformans and Cryptococcus gattii and coinfection with paracoccidioidomycosis in PLHIV

Medical Mycology Case Reports, 2022
We present a rare condition of mixed C. neoformans and C. gattii infection in a person living with HIV with false-negative CrAg LFA in the CSF and co-infection with paracoccidioidomycosis.
Marcela de Faria Ferreira, Fabio Brito-Santos, Pedro Henrique Nascimento Theodoro, Marcos de Abreu Almeida, Marcia dos Santos Lazera, Luciana Trilles   +5 more
doaj   +1 more source