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Annals of Internal Medicine, 2023 Chagas disease, which is caused by infection with the parasite Trypanosoma cruzi, is a leading neglected tropical disease in the United States. An estimated 240 000 to 350 000 persons in the United States are infected, primarily immigrants from Mexico ...
N. Hochberg, S. Montgomery
semanticscholar +4 more sources
In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi. [PDF]
, 2010 BackgroundCruzain, the major cysteine protease of Trypanosoma cruzi, is an essential enzyme for the parasite life cycle and has been validated as a viable target to treat Chagas' disease.
Brinen, Linda S +6 more
core +57 more sources
Chagas Disease: From Discovery to a Worldwide Health Problem
Frontiers in Public Health, 2019 Carlos Chagas discovered American trypanosomiasis, also named Chagas disease (CD) in his honor, just over a century ago. He described the clinical aspects of the disease, characterized by its etiological agent (Trypanosoma cruzi) and identified its ...
Kárita Cláudia Freitas Lidani +2 more
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Chagas Disease in the United States: a Public Health Approach
Clinical Microbiology Reviews, 2019 Trypanosoma cruzi is the etiological agent of Chagas disease, usually transmitted by triatomine vectors. An estimated 20 to 30% of infected individuals develop potentially lethal cardiac or gastrointestinal disease.
Louisa A Messenger, Jeffrey D Whitman
exaly +2 more sources
Acute Chagas Disease: New Global Challenges for an Old Neglected Disease [PDF]
PLoS Neglected Tropical Diseases, 2014 Chagas disease is caused by infection with the protozoan Trypanosoma cruzi, and although over 100 years have passed since the discovery of Chagas disease, it still presents an increasing problem for global public health.
Daniela V Andrade +2 more
exaly +2 more sources
Congenital Chagas disease: A cohort study to assess molecular diagnostic methods at the Chagas disease national reference center of Argentina. [PDF]
PLoS Neglected Tropical DiseasesBackgroundTrypanosoma cruzi is a protozoan parasite which causes Chagas disease. Mother-to-child transmission is the main route of transmission in vector-free areas.
Constanza Lopez-Albizu +6 more
doaj +2 more sources
The Unsolved Jigsaw Puzzle of the Immune Response in Chagas Disease
Frontiers in Immunology, 2018 Trypanosoma cruzi interacts with the different arms of the innate and adaptive host's immune response in a very complex and flowery manner. The history of host-parasite co-evolution has provided this protozoan with means of resisting, escaping or ...
Gonzalo R Acevedo, Karina A Gómez
exaly +2 more sources
Neglected Tropical Diseases, 2021 In most cases, Chagas disease begins with a bite by the triatomine bug, also known as the “kissing bug” because it bites people’s faces when they sleep. Often people are infected without even noticing it.
Paula E. Stigler Granados +1 more
semanticscholar +2 more sources
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023 Background Chagas disease (CD) presents an ominous prognosis. The predictive value of biomarkers and new echocardiogram parameters in adjusted models have not been well studied.
Veronica G. Mendes +21 more
doaj +1 more source
What Do You Need to Know before Studying Chagas Disease? A Beginner’s Guide
Tropical Medicine and Infectious Disease, 2023 Chagas disease is one of the most important tropical infections in the world and mainly affects poor people. The causative agent is the hemoflagellate protozoan Trypanosoma cruzi, which circulates among insect vectors and mammals throughout the Americas.
J. A. De Fuentes-Vicente +8 more
semanticscholar +1 more source