Results 1 to 10 of about 9,321,926 (310)
In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi. [PDF]
, 2010 BackgroundCruzain, the major cysteine protease of Trypanosoma cruzi, is an essential enzyme for the parasite life cycle and has been validated as a viable target to treat Chagas' disease.
Brinen, Linda S +6 more
core +52 more sources
Chagas Disease in the United States: a Public Health Approach
Clinical Microbiology Reviews, 2019 Trypanosoma cruzi is the etiological agent of Chagas disease, usually transmitted by triatomine vectors. An estimated 20 to 30% of infected individuals develop potentially lethal cardiac or gastrointestinal disease.
Louisa A Messenger, Jeffrey D Whitman
exaly +2 more sources
Chagas Disease: From Discovery to a Worldwide Health Problem
Frontiers in Public Health, 2019 Carlos Chagas discovered American trypanosomiasis, also named Chagas disease (CD) in his honor, just over a century ago. He described the clinical aspects of the disease, characterized by its etiological agent (Trypanosoma cruzi) and identified its ...
Kárita Cláudia Freitas Lidani +2 more
exaly +2 more sources
Congenital Chagas disease: A cohort study to assess molecular diagnostic methods at the Chagas disease national reference center of Argentina. [PDF]
PLoS Neglected Tropical DiseasesBackgroundTrypanosoma cruzi is a protozoan parasite which causes Chagas disease. Mother-to-child transmission is the main route of transmission in vector-free areas.
Constanza Lopez-Albizu +6 more
doaj +2 more sources
Annals of Internal Medicine, 2023 Chagas disease, which is caused by infection with the parasite Trypanosoma cruzi, is a leading neglected tropical disease in the United States. An estimated 240 000 to 350 000 persons in the United States are infected, primarily immigrants from Mexico ...
Natasha S. Hochberg, Susan P. Montgomery
semanticscholar +2 more sources
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023 Background Chagas disease (CD) presents an ominous prognosis. The predictive value of biomarkers and new echocardiogram parameters in adjusted models have not been well studied.
Veronica G. Mendes +21 more
doaj +1 more source
Navigating drug repurposing for Chagas disease: advances, challenges, and opportunities
Frontiers in Pharmacology, 2023 Chagas disease is a vector-borne illness caused by the protozoan parasite Trypanosoma cruzi (T. cruzi). It poses a significant public health burden, particularly in the poorest regions of Latin America.
Exequiel O. J. Porta +2 more
semanticscholar +1 more source
The epidemiology of Chagas disease in the Americas. [PDF]
Lancet Reg Health AmCucunubá ZM +10 more
europepmc +2 more sources
What Do You Need to Know before Studying Chagas Disease? A Beginner’s Guide
Tropical Medicine and Infectious Disease, 2023 Chagas disease is one of the most important tropical infections in the world and mainly affects poor people. The causative agent is the hemoflagellate protozoan Trypanosoma cruzi, which circulates among insect vectors and mammals throughout the Americas.
J. A. De Fuentes-Vicente +8 more
semanticscholar +1 more source
Nature Microbiology, 2022 Trypanosoma cruzi, the agent of Chagas disease, probably infects tens of millions of people, primarily in Latin America, causing morbidity and mortality. The options for treatment and prevention of Chagas disease are limited and underutilized.
A. Padilla +19 more
semanticscholar +1 more source