Results 91 to 100 of about 414,156 (339)

Spontaneous symmetry breaking by double lithium adsorption in polyacenes

, 2010
We show that adsorption of one lithium atom to a polyacenes, i.e. chains of linearly fused benzene rings, will cause this chain to be slightly deformed.
Ortiz, Yenni P., Seligman, Thomas H.
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

(E)-N-[2-(Biphenyl-4-ylvinyl)phenyl]furan-2-carboxamide

Acta Crystallographica Section E, 2008
In the title molecule, C25H19NO2, the furyl ring is twisted by 46.3 (1)° with respect to the phenylene ring bearing the amido group. In the stilbene unit, the two phenylene rings (i.e.
Noel F. Thomas, Azhar Ariffin, Khalijah Awang, Seik Weng Ng, Chin Hui Kee   +4 more
doaj   +1 more source

Descending Chain Conditions and Graded Rings

Journal of Algebra, 1995
Let \(S\) be a semigroup, let \(R=\bigoplus R_s\) (\(s\in R\)) be an \(S\)-graded ring, and let \(J(R)\) be the Jacobson radical of \(R\). Put \(J_{\text{gr}}(R)=\bigoplus(R_s\cap J(R))\); \(J_{\text{gr}}(R)\) is called the homogeneous part of \(J(R)\). For \(R\) satisfying certain classical finiteness conditions, a description of \(R/J_{\text{gr}}(R)\)
Jespers, E., Okninski, J.
openaire   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

An amphiphilic pseudo[1]catenane: neutral guest-induced clouding point change

Beilstein Journal of Organic Chemistry, 2018
The hydrophobic/hydrophilic ratio in a molecule largely affects its assembled properties in aqueous media. In this study, we synthesized a new bicyclic compound which could dynamically change its hydrophobic/hydrophilic ratio by chemical stimulus.
Tomoki Ogoshi, Tomohiro Akutsu, Tada-aki Yamagishi   +2 more
doaj   +1 more source

Observation of interacting Josephson vortex chains by magnetic force microscopy

Physical Review Research, 2020
The ability to control Josephson vortices is instrumental for development of superconducting cryoelectronics. However, direct visualization of multivortex states in Josephson junctions is a challenging task.
Sergey Yu. Grebenchuk, Razmik A. Hovhannisyan, Viacheslav V. Dremov, Andrey G. Shishkin, Vladimir I. Chichkov, Alexander A. Golubov, Dimitri Roditchev, Vladimir M. Krasnov, Vasily S. Stolyarov   +8 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

MDS and MHDR Cyclic Codes over Finite Chain Rings

Journal of Mathematics
This work establishes a unique set of generators for a cyclic code over a finite chain ring. Towards this, we first determine the minimal spanning set and rank of the code.
Monika Dalal, Sucheta Dutt, Ranjeet Sehmi   +2 more
doaj   +1 more source