Results 101 to 110 of about 28,625 (273)

Addressing Data Point Homogeneity and Annotation Challenges to Enhance Data‐Driven Approaches: The S. aureus NorA Efflux Pump Case Study

ChemMedChem, Volume 20, Issue 9, May 5, 2025.
Analysis of publicly available data on the biological activities associated with the Staphylococcus aureus NorA efflux pump shows critical inconsistencies and homogeneity issues that hinder the discovery of NorA inhibitors. Based on the tips extracted from this analysis, a standardized experimental pipeline is proposed to improve data quality and ...
Andrea Astolfi, Giada Cernicchi, Erika Primavera, Marco Rocchi, Giuseppe Manfroni, Stefano Sabatini, Maria Letizia Barreca   +6 more
wiley   +1 more source

Hybrid Molecules as Efficient Drugs against Multidrug‐Resistant Malaria Parasites

ChemMedChem, EarlyView.
Among hybrid molecules currently developed as antimalarial drug candidates, emoquine‐1 exhibits high activity against all the multidrug‐resistant Plasmodium strains tested up to now, including artemisinin‐resistant quiescent parasites, critical parameters for promising antimalarial drugs. It is also curative in mouse malaria.
Anne Robert, Lucie Paloque, Jean‐Michel Augereau, Flore Nardella, Michel Nguyen, Bernard Meunier, Françoise Benoit‐Vical   +6 more
wiley   +1 more source

SAR and molecular mechanism studies of monoamine oxidase inhibition by selected chalcone analogs

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
The present study describes the synthesis of a series of 22 chalcone analogs. These compounds were evaluated as potential human MAO-A and MAO-B inhibitors. The compounds showed varied selectivity against the two isoforms. The IC50 values were found to be
Raed Shalaby, Jacobus P. Petzer, Anél Petzer, Usman M. Ashraf, Ealla Atari, Fawaz Alasmari, Sivarajan Kumarasamy, Youssef Sari, Ashraf Khalil   +8 more
doaj   +1 more source

Intracellular and Extracellular Efficacy of Homoisoflavone Derivatives Against Mycobacterium tuberculosis: Progress Toward Novel Antitubercular Agents

ChemMedChem, Accepted Article.
Tuberculosis (TB) is the leading cause of death among infectious diseases, and new studies focusing new anti‐TB drugs are urgent due to the emergence of drug‐resistant strains. In this regard, homoisoflavones, an underexplored subgroup of flavonoids, were explored for their potential as anti‐TB agents.
Sanderson D. Calixto, Juliane S. Falcão, Stella S. Antunes, Marlon H. Araujo, Alexandre L. B. Cunha, David R. Martins, Sarah M. R. Nascimento, Thatiana L. B. V. Simão, Elena B. Lasunskaia, Nelilma C. Romeiro, Paulo R. R. Costa, Michelle Muzitano, Guilherme S. Caleffi   +12 more
wiley   +1 more source

Sustainable and Scalable Enzymatic Production, Structural Elucidation, And Biological Evaluation of Novel Phlorizin Analogues

ChemSusChem, Volume 18, Issue 8, April 14, 2025.
New α‐glycosides of chalcones and dihydrochalcones, analogues of naturally occurring phlorizin, have been synthesized using a CGTase‐catalyzed glycosylation that was successfully scaled‐up in a 10‐liter reactor. The α‐glycosides were (i) purified using an original centrifugal partition chromatography technique, (ii) characterized through NMR and LC–MS ...
Laurène Minsat, Yueying Li, Cédric Peyrot, Agathe Martinez, Nicolas Borie, Aurélien Peru, Blandine Godon, Clément Nève, Fanny Brunissen, Fanny Brunois, Abdouramane Dosso, Florent Allais, Jean‐Hugues Renault   +12 more
wiley   +1 more source

Chalcones. XVIII : Potential Germicides Derived from Hydroxy Acetonaphthones [PDF]

, 1976
SHYAM SUNDER MISRA
openalex   +1 more source

Challenges and Opportunities in the Use of Iron Photosensitizers for Dye‐Sensitized Solar Cells and Photoelectrosynthetic Cells Applications

EcoEnergy, EarlyView.
This review gathers examples of iron‐based photosensitizers that have been successfully immobilized on metal oxide surfaces for dye‐sensitized solar cells and potential dye‐sensitized photoelectrosynthesic cells applications. A critical comparison of Fe‐based photosensitizers is made based on their photophysical properties, electrochemistry, and ...
Lakshmi Narayan Satheesh, Katerina Achilleos, Abdullah M. Abudayyeh, Ludovic Troian‐Gautier   +3 more
wiley   +1 more source

Ammoniation of Dietary Flavonoids Containing a Pyrogallol Group With Amino Acids at 37°C

Food Chemistry International, EarlyView.
Scheme of reaction exploration, synthesis, structural identification, and bioactivities of ammoniated flavonoids. ABSTRACT New research shows that flavonoids containing a pyrogallol group in ring B react with amino acids at 37°C, forming ammoniated derivatives and aldehydes.
Haolin Zhang, Hui Cao, Chuanming Yu, Mohamed A. Farag, Avi Shpigelman, Zhuobin Li, Chunlin Li, Jianbo Xiao   +7 more
wiley   +1 more source

How Does Nature Create the Painting “Gradient Coloration of ‘Manicure Finger’ Grape”? Integrated Omics Unveil the Pigments Basis and Metabolism Networks of Its Formation

Food Frontiers, Volume 6, Issue 2, Page 921-939, March 2025.
Based on integrated omics, the metabolic regulation networks underlying gradient coloration of ‘Manicure Finger’ grape were constructed at three levels of color‐presenting substances, structural genes, and transcription factors. ABSTRACT ‘Manicure Finger’ grape exhibits gradient coloration during veraison, where the lower part of the skin changes color
Shihan Bao, Jianing Li, Jiaqi Wang, Tian Lan, Mengyuan Wei, Xiangyu Sun, Yulin Fang, Tingting Ma   +7 more
wiley   +1 more source

Biotechnology Advances in Natural Food Colorant Acylated Anthocyanin Production

Food Frontiers, Volume 6, Issue 2, Page 698-715, March 2025.
ABSTRACT The food application of natural blue colorants such as acylated anthocyanin is becoming increasingly popular due to their safety, nutritional value, organoleptic attributes, and more pH/thermo‐stable properties compared to nonacylated anthocyanins.
Shaohua Zeng, Shuang Lin, Rong Jiang, Jinrong Wei, Ying Wang   +4 more
wiley   +1 more source