Results 201 to 210 of about 48,655 (255)

Synthesis of Isobenzofuranones and Isoindolinones via Claisen-Schmidt Condensation and Their Antileishmanial Activity. [PDF]

open access: yesACS Omega
Khotsombat S   +10 more
europepmc   +1 more source
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Anticancer activities of novel chalcone and bis-chalcone derivatives

Bioorganic and Medicinal Chemistry, 2006
A series of novel chalcones and bis-chalcones containing boronic acid moieties has been synthesized and evaluated for antitumor activity against the human breast cancer MDA-MB-231 (estrogen receptor-negative) and MCF7 (estrogen receptor-positive) cell lines and against two normal breast epithelial cell lines, MCF-10A and MCF-12A.
Nancy E Davidson
exaly   +3 more sources

Bioactivities of Chalcones

Current Medicinal Chemistry, 1999
This review outlines the different bioactivities of a variety of chalcones. The cytotoxic, anticancer, chemopreventative and mutagenic properties of a number of chalcones are described followed by an account of various of these unsaturated ketones as antimicrobial agents.
J R, Dimmock   +3 more
openaire   +2 more sources

Chalcone dihalides—VII

Tetrahedron, 1975
Abstract 2′-hydroxychalcone dibromides substituted by OMe in the 6′-position are found to yield little or no aurone in dilute aqueous ethanolic potassium hydroxide. The proportion of aurone to flavone in their products parallels increasing hydroxide concentration.
J.A. Donnelly, H.J. Doran
openaire   +1 more source

Anti‐tumorigenic chalcones

STEM CELLS, 1994
On the basis of our recent findings that licochalcone A isolated from Xin-jiang licorice showed anti-inflammatory and anti-tumorigenic activities, we synthesized more than 40 chalcone derivatives to examine their anti-tumorigenic activities. In vitro inhibitory activity against phosphorylation of phospholipids promoted by tetradecanoylphorbol-13 ...
openaire   +2 more sources

Stereoselectivity of chalcone isomerase with chalcone derivatives: a computational study

Journal of Molecular Modeling, 2013
Chalcone isomerase (CHI) catalyzes the intramolecular cyclization of chalcones into flavonoids. The activity of CHI is essential for the biosynthesis of flavonoids precursors of floral pigments and phenylpropanoid plant defense compounds. In the present study, we explored the detailed binding structures and binding free energies for two different ...
Yuan, Yao, Hui, Zhang, Ze-Sheng, Li
openaire   +2 more sources

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