Results 1 to 10 of about 22,032 (252)
Pharmacotherapeutics Applications and Chemistry of Chalcone Derivatives [PDF]
Molecules, 2022 Chalcones have been well examined in the extant literature and demonstrated antibacterial, antifungal, anti-inflammatory, and anticancer properties.
Jagjit Singh Dhaliwal +11 more
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Chalcone Derivatives: Role in Anticancer Therapy. [PDF]
Biomolecules, 2021 Chalcones (1,3-diaryl-2-propen-1-ones) are precursors for flavonoids and isoflavonoids, which are common simple chemical scaffolds found in many naturally occurring compounds. Many chalcone derivatives were also prepared due to their convenient synthesis.
Ouyang Y +5 more
europepmc +5 more sources
A review on synthetic chalcone derivatives as tubulin polymerisation inhibitors [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 Microtubules play an important role in the process of cell mitosis and can form a spindle in the mitotic prophase of the cell, which can pull chromosomes to the ends of the cell and then divide into two daughter cells to complete the process of mitosis ...
Wenjing Liu +4 more
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Synthesis of Anti-Inflammatory Drugs’ Chalcone Derivatives and a Study of Their Conformational Properties Through a Combination of Nuclear Magnetic Resonance Spectroscopy and Molecular Modeling [PDF]
PharmaceuticalsBackground: In this study, two chalcone analogs were synthesized through in silico and experimental methods, and their potential to inhibit the lipoxygenase enzyme, which plays a role in the inflammation pathway, was assessed. Specifically, this study is
Nikitas Georgiou +9 more
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Chalcone Derivatives: Promising Starting Points for Drug Design [PDF]
Molecules, 2017 Medicinal chemists continue to be fascinated by chalcone derivatives because of their simple chemistry, ease of hydrogen atom manipulation, straightforward synthesis, and a variety of promising biological activities.
Marcelo N. Gomes +7 more
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Green synthesis of chalcones derivatives [PDF]
AIP Conference Proceedings, 2021 Chalcone is a common natural pigment and one of the important intermediates in flavonoid biosynthesis. It has broad bioactivities such as anti-inflammatory, anti-cancer, and anti-fungal properties. In this research, chalcone derivatives were synthesized as a precursor of hydrogenation transfer reaction to afford dihydrochalcones.
Dewi Septianingtyas +4 more
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Molecules, 2023 Chalcones are interesting anticancer drug candidates which have attracted much interest due to their unique structure and their extensive biological activity.
Mahmoud I. M. Darwish +10 more
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Synthesis and Evaluation of Chalcone Derivatives as Novel Sunscreen Agent
Molecules, 2021 Ultraviolet (UV) irradiation is a serious problem for skin health thus the interest in the research to develop sunscreen agent has been increasing. Chalcone is a promising compound to be developed as its chromophore absorbs in the UV region.
Lucia Wiwid Wijayanti +3 more
doaj +1 more source
Ferrocenyl chalcone derivatives as possible antimicrobial agents [PDF]
The Journal of Antibiotics, 2020 The swift spread of infections caused by drug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), has quickly become a worldwide concern as infections spread from healthcare settings to the wider community. While ferrocenyl chalcones, which are chalcone derivatives with antimicrobial activity, have gained attention from ...
Elecia J. Henry +4 more
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Steroidal chalcones and derivatives: a review
Arkivoc, 2021 It was observed that the presence of heterocycles to steroids often leads to a change in their physiological activity and the appearance of new interesting biological precursors. Recent developments in the syntheses of steroidal chalcones and their derivatives are described herein. The biological activities of those steroidal derivatives for which data
Ibrahim-Ouali, Malika, Dumur, Frédéric
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