Unveiling the Anticancer Properties of New Synthesized Alkoxy‐ and Methyl Thio‐Chalcone Derivatives
Natural SciencesBreast and cervical cancers are a serious problem and the leading cause of death in women in this decade. Chalcone is a promising compound with great potential for anticancer use.
Nurcahyo Iman Prakoso +9 more
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Natural Product Rottlerin Derivatives Targeting Quorum Sensing
Molecules, 2021 Rottlerin is a natural product consisting of chalcone and flavonoid scaffolds, both of which have previously shown quorum sensing (QS) inhibition in various bacteria.
Dittu Suresh +6 more
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Synthesis and Biological Evaluation of Amino Chalcone Derivatives as Antiproliferative Agents
Molecules, 2020 Chalcone is a common scaffold found in many biologically active compounds. The chalcone scaffold was also frequently utilized to design novel anticancer agents with potent biological efficacy.
Chao-Fan Lu +14 more
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Chalcones: Synthetic Chemistry Follows Where Nature Leads
Biomolecules, 2021 Chalcones belong to the flavonoid class of phenolic compounds. They form one of the largest groups of bioactive natural products. The potential anticancer, anti-inflammatory, antimicrobial, antioxidant, and antiparasitic properties of naturally occurring
Hiba A. Jasim +5 more
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Synthesis of Quinazolinyl Chalcone Derivatives [PDF]
Proceedings of the 3rd International Conference on Material, Mechanical and Manufacturing Engineering, 2015 quinazolin-ylamino) phenyl-4-(N,N- dimethylamino) phenyl propenyl ketone with total yield of 68.0% was synthesized with 2-aminobenzonitrile and N,N-dimethylformamide dimethyl acetal as a starting material, the synthesis of N-(2-cyanophenyl)-N,N-dimethyl formami- dine, and then amino acetophenone to form a ring, and finally reaction with formaldehyde ...
Wei Liu +9 more
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Stress Resistance Screen in a Human Primary Cell Line Identifies Small Molecules That Affect Aging Pathways and Extend Caenorhabditis elegans' Lifespan. [PDF]
, 2020 Increased resistance to environmental stress at the cellular level is correlated with the longevity of long-lived mutants and wild-animal species. Moreover, in experimental organisms, screens for increased stress resistance have yielded mutants that are ...
Ang, Kenny Kean-Hooi +5 more
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Indonesian Journal of Chemistry, 2018 The synthesis of chalcone derivatives as target compounds and anticancer test against breast (T47D) and colon (WiDr) cell line had been performed.
Chairil Anwar +5 more
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Chalcone Scaffolds, Bioprecursors of Flavonoids: Chemistry, Bioactivities, and Pharmacokinetics
Molecules, 2021 Chalcones are secondary metabolites belonging to the flavonoid (C6-C3-C6 system) family that are ubiquitous in edible and medicinal plants, and they are bioprecursors of plant flavonoids.
Mithun Rudrapal +7 more
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Cytotoxic Activity of Methoxy-4’amino Chalcone Derivatives Against Leukemia Cell Lines
MCBS (Molecular and Cellular Biomedical Sciences), 2019 Background: Chemotherapy is a common treatment for leukemia as well as in other cancer treatment. The lack of tumor selectivity and development of multi-drug resistance by chemotherapy caused the development of new strategy in cancer treatment become a ...
Arina Novilla +4 more
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Novel chalcone-based fluorescent human histamine H 3 receptor ligands as pharmacological tools [PDF]
, 2012 Novel fluorescent chalcone-based ligands at human histamine H(3) receptors (hH(3)R) have been designed, synthesized, and characterized. Compounds described are non-imidazole analogs of ciproxifan with a tetralone motif.
Tomasch, Miriam +3 more
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