Design and synthesis of new inhibitors of p53–MDM2 interaction with a chalcone scaffold [PDF]
, 2019 The virtual screening of a library of chalcone derivatives led us to the identification of potential new MDM2 ligands. The chalcones with the best docking scores obeying the Lipinski rule of five were subsequently prepared by base-catalyzed aldol ...
Cidade, Honorina +12 more
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Chalcone derivatives as potential antifungal agents: Synthesis, and antifungal activity
Journal of Advanced Pharmaceutical Technology & Research, 2015 Much research has been carried out with the aim to discover the therapeutic values of chalcone derivatives. Chalcones possess wide range of pharmacological activity such as antibacterial, antimalarial, antiprotozoal, antitubercular, anticancer, and ...
Deepa Gupta, D K Jain
doaj +1 more source
The Benefits of Chalcone and Its Derivatives as Antibacterial Agents: A Review
BIO Web of Conferences, 2020 Chalcone is a secondary metabolite compound found in plants. Chalcones contain two aryl rings, namely ring A and B which connected to the α,β unsaturated ketones.
Mustikasari Kamilia +1 more
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Green Synthesis of Chalcone Derivatives Using Chalcones as Precursor
, 2022 Recently, the use of green methodologies like sonication, use of ionic liquids, etc. attracted the attention of researchers in the field of organic synthesis as they have advantages such as mild reaction conditions, environmentally benign procedures, etc.
Surbhi, Dhadda, +2 more
openaire +2 more sources
Ethanol triggers grape gene expression leading to anthocyanin accumulation during berry ripening [PDF]
, 2002 Recent studies have shown that low doses of ethanol stimulate the maturation of some fruits. The present work showed that spraying Cabernet Sauvignon grapes, with 5% ethanol at veraison enhances the anthocyanin accumulation.
Chervin, Christian +9 more
core +4 more sources
Design, synthesis, docking studies and monoamine oxidase inhibition of a small library of 1-acetyl- and 1-thiocarbamoyl-3,5-diphenyl-4,5-dihydro-(1h)-pyrazoles [PDF]
, 2019 New N-acetyl/N-thiocarbamoylpyrazoline derivatives were designed and synthesized in high yields to assess their inhibitory activity and selectivity against human monoamine oxidase A and B.
Carradori, Simone +8 more
core +2 more sources
SYNTHESIS AND CYTOTOXIC ACTIVITY OF CHALCONE DERIVATIVES ON HUMAN BREAST CANCER CELL LINES
Indonesian Journal of Chemistry, 2012 Chalcone, an α,β-unsaturated ketone, has been shown have many biological activities such as anticancer and antifungi. This research was conducted to synthesize the chalcone derivatives and to obtain their cytotoxic activity on human cervix cancer cell ...
Nuraini Harmastuti +4 more
doaj +1 more source
Control of anthocyanin biosynthesis pathway gene expression by eutypine, a toxin from Eutypa lata, in grape cell tissue cultures [PDF]
, 2003 Eutypine, 4-hydroxy-3-(3-methyl-3-butene-1-ynyl) benzaldehyde, is a toxin produced by Eutypa lata, the causal agent of Eutypa dieback in grapevine. The effect of the toxin on anthocyanin synthesis has been investigated in Vitis vinifera cv.
Afifi, Maha +6 more
core +4 more sources
Acta Chimica Slovenica, 2020 1-Phenyl-5-substituted-3-(4-(trifluoromethyl)phenyl)-4,5-dihydro-1H-pyrazole derivatives were synthesized from chalcone derivatives. The structures of compounds were characterized by IR, 1H NMR spectroscopic methods and elemental analysis.
Fatih Tok +1 more
doaj +1 more source
Tikrit Journal of Pure Science, 2023 A number of 3-(substituted)-5-(2((4-chlorobenzyl)oxy)-5-(m-tolyldizenyl) pheny l) pyrazoline (3a-j) have been synthesized by benzyloxation of hydroxyl group to give the substrate 2-((4-chlorobenzyl)oxy)-5-(m-tolyldizenyl) benzaldehyde (1). The compound (
Ahmed A. ALKazmi +2 more
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