Results 91 to 100 of about 2,120,441 (365)
Change management in objectbases
, 1994 In OODBMSs type-specific methods are used for manipulating objects, in order to maintain the consistency of the database. This is, however, of little help for the method implementor as far as the model-inherent constraints are concerned. We propose a set of generic update operations, including operations for object evolution that maintain integrity ...
Laasch, Christian, Scholl, Marc H.
openaire +3 more sources
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Management Enforced Job Change and Employee Perceptions of the Psychological Contract
, 1997 Despite increasing research interest in the psychological contract, little is known about how employees' contractual beliefs alter during major organizational changes.
Hallier, Jerry, James, Philip
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Passive Trust or Active Application: Changes in the Management of Difficult Childbirth and the Edinburgh Royal Maternity Hospital, 1850–1890 [PDF]
, 2006 Alison Nuttall
openalex +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Adaptation Decision Support: An Application of System Dynamics Modeling in Coastal Communities
International Journal of Disaster Risk Science, 2017 This research develops and applies a system dynamics (SD) model for the strategic evaluation of environmental adaptation options for coastal communities.
Daniel Lane +2 more
doaj +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Management of IT-enabled Change in a Public Organization in Tanzania
, 2007 The implementation of Information Technology (IT) is always associated with organisational change issues and in developing countries this is even more complex due to poorer and less established IT resources and governance.
Rusu, Lazar,, Nfuka, Edephonce,
core +2 more sources