Results 61 to 70 of about 2,120,441 (365)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Meeting the challenges of game ranch management
Koedoe: African Protected Area Conservation and Science, 2011 Meeting the challenges of game ranch ...
Roger Collinson
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
International Journal of Forestry ResearchParticipatory forest management (PFM) is increasingly recognized as an effective approach for forest conservation and sustainable resource use in Ethiopia, yet empirical evidence of its ecological outcomes remains limited. This study assessed the effects
Sintayehu Getie +3 more
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Organizational choice and organizational change
, 1997 Follows on from and develops the arguments presented in an earlier Management Decision article ‐ "No such thing as ... a ‘one best way' to manage organizational change" (Burnes, 1996a). Begins by examining Burnes' (1996b) Choice Management ‐ Change
Burnes, Bernard
core +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
The Impact of Ethical Plans on Job Satisfaction through Perceived Corporate Social Responsibility and Organizational Ethical Environment. [PDF]
فرایند مدیریت و توسعه, 2020 While the Iranian community is perceived to be a religious and ethical community, the ethical challenges existing in the country's organizations suggest that ethics development cannot be achieved solely through preaching and promotional activities ...
Parivash Tahmasebi, Firouz Raznahan
doaj
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Local Knowledge and Natural Resource Management in a Peasant Farming\n Community Facing Rapid Change: A Critical Examination [PDF]
, 2022 Jules Siedenburg
openalex +1 more source