Results 71 to 80 of about 4,557,905 (293)

A Tractable and Efficient One-Pot Synthesis of 5'-Azido-5'-deoxyribonucleosides

Molecules, 2014
Synthetic routes to 5'-azidoribonucleosides are reported for adenosine, cytidine, guanosine, and uridine, resulting in a widely applicable one-pot methodology for the synthesis of these and related compounds.
Theodore V. Peterson, Tobin U. B. Streamland, Ahmed M. Awad   +2 more
doaj   +1 more source

Optimal linear optical implementation of a single-qubit damping channel

, 2011
We experimentally demonstrate a single-qubit decohering quantum channel using linear optics. We implement the channel, whose special cases include both the amplitude-damping channel and the bit-flip channel, using a single, static optical setup ...
Fisher, Kent, Kaltenbaek, Rainer, Prevedel, Robert, Resch, Kevin J.   +3 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

S.3827 and a Systematic Review of State-Level Multisector Plans for Aging: How Incorporating Volunteer Caregiving Can Mitigate Service Gaps

Inquiry: The Journal of Health Care Organization, Provision, and Financing
Recognizing the growing need to establish and enhance the necessary service infrastructure to better address the diverse needs of a rapidly aging US population, S.3827 (ie, Strategic Plan for Aging Act) seeks to provide federal support for the creation ...
Ronald W. Berkowsky PhD, Blake Adams BS, Robyn Villa BS, Tammy I. Glenn MBA   +3 more
doaj   +1 more source

Activity-dependent regulation of T-type calcium channels by submembrane calcium ions

eLife, 2017
Voltage-gated Ca2+ channels are involved in numerous physiological functions and various mechanisms finely tune their activity, including the Ca2+ ion itself.
Magali Cazade, Isabelle Bidaud, Philippe Lory, Jean Chemin   +3 more
doaj   +1 more source

Random-Matrix Theory of Electron Transport in Disordered Wires with Symplectic Symmetry

, 2006
The conductance of disordered wires with symplectic symmetry is studied by a random-matrix approach. It has been believed that Anderson localization inevitably arises in ordinary disordered wires.
Altland A., Ando T., Ando T., Beenakker C. W. J., Brouwer P. W., Caselle M., Dorokhov O. N., Efetov K., Gruzberg I. A., Macêdo A. M. S., Mehta M. L., Mello P. A., Mello P. A., Mello P. A., Mirlin A. D., Nakanishi T., Sakai H., Takane Y., Takane Y., Takane Y., Takane Y., Takane Y., Zirnbauer M. R.   +22 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Short‐chain mono‐carboxylates as negative modulators of allosteric transitions in Gloeobacter violaceus ligand‐gated ion channel, and impact of a pre‐β5 strand (Loop Ω) double mutation on crotonate, not butyrate effect

Physiological Reports
Using the bacterial proton‐activated pentameric receptor‐channel Gloeobacter violaceus ligand‐gated ion channel (GLIC): (1) We characterize saturated, mono‐carboxylates as negative modulators of GLIC (as previously shown for crotonate; Alqazzaz et al ...
Catherine Van Renterghem, Ákos Nemecz, Karima Medjebeur, Pierre‐Jean Corringer   +3 more
doaj   +1 more source

Feedback Capacity of the Compound Channel

, 2007
In this work we find the capacity of a compound finite-state channel with time-invariant deterministic feedback. The model we consider involves the use of fixed length block codes. Our achievability result includes a proof of the existence of a universal
Permuter, Haim, Shrader, Brooke
core   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source