Results 51 to 60 of about 1,082,369 (299)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Efficient phase-space generation for hadron collider event simulation

SciPost Physics, 2023
We present a simple yet efficient algorithm for phase-space integration at hadron colliders. Individual mappings consist of a single t-channel combined with any number of s-channel decays, and are constructed using diagrammatic information. The factorial
Enrico Bothmann, Taylor Childers, Walter Giele, Florian Herren, Stefan Höche, Joshua Isaacson, Max Knobbe, Rui Wang
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Gate-controlled reversible rectifying behaviour in tunnel contacted atomically-thin MoS$_{2}$ transistor

, 2017
Atomically-thin 2D semiconducting materials integrated into van der Waals heterostructures have enabled architectures that hold great promise for next generation nanoelectronics.
Bouchiat, Vincent, Chen, Jianhao, Chen, Maolin, Fan, Zhiqiang, Guo, Junjie, Han, Zheng Vitto, Jia, Chuankun, Jiang, Xiangwei, Li, Xiaoxi, Liu, Peizhi, Liu, Xin, Sun, Dongming, Zhang, Zhidong   +12 more
core   +5 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

An Approach for Accelerating Incompressible Turbulent Flow Simulations Based on Simultaneous Modelling of Multiple Ensembles

, 2018
The present paper deals with the problem of improving the efficiency of large scale turbulent flow simulations. The high-fidelity methods for modelling turbulent flows become available for a wider range of applications thanks to the constant growth of ...
Krasnopolsky, Boris
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Reply to "Comment on 'Isotope effect in multi-band and multi-channel attractive systems and inverse isotope effect in iron-based superconductors'"

, 2011
The Comment insists on the following: in our model it is assumed that the effective interactions have specific energy ranges within the single band with a cutoff at \omega_1 for the phononic part and a range from \omega_1 to \omega_2 in the AF channel ...
Eisaki, Hiroshi, Hase, Izumi, Iyo, Akira, Odagiri, Kosuke, Shirage, Parasharam M., Tanaka, Yasumoto, Yamaji, Kunihiko, Yanagisawa, Takashi   +7 more
core   +1 more source

From Multichannel to Omnichannel: Measuring Channel Integration and Digital Adoption Patterns

Journal of Theoretical and Applied Electronic Commerce Research
The digitalization of business activities is already a reality in most developed countries. India, driven by strong information technology, is rapidly digitalizing across business industries.
Mohammed Avvad, T. Radha Ramanan, Muhammad Shafi Keelath, B. M. Rijas   +3 more
doaj   +1 more source