Results 61 to 70 of about 1,082,369 (299)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Method and apparatus for frequency spectrum analysis [PDF]

, 1992
A method for frequency spectrum analysis of an unknown signal in real-time is discussed. The method is based upon integration of 1-bit samples of signal voltage amplitude corresponding to sine or cosine phases of a controlled center frequency clock which
Cole, Steven W.
core   +1 more source

Coexistence of continuous variable QKD with intense DWDM classical channels

, 2015
We demonstrate experimentally the feasibility of continuous variable quantum key distribution (CV-QKD) in dense-wavelength-division multiplexing networks (DWDM), where QKD will typically have to coexist with several co- propagating (forward or backward ...
Alléaume, Romain, Kumar, Rupesh, Qin, Hao   +2 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Dynamical simulation of transport in one-dimensional quantum wires

, 1995
Transport of single-channel spinless interacting fermions (Luttinger liquid) through a barrier has been studied by numerically exact quantum Monte Carlo methods.
A. P. Vinogradov, A. Schmid, C. H. Mak, C. H. Mak, C. H. Mak, C. L. Kane, F. D. M. Haldane, F. Guinea, J. D. Doll, J. D. Doll, J. E. Gubernatis, J. M. Luttinger, K. A. Matveev, K. A. Matveev, K. Moon, Kevin Leung, M. P. A. Fisher, N. Makri, N. Makri, P. Fendley, R. Egger, Reinhold Egger, S. Tarucha, V. S. Filinov   +23 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Active Integrated Filters for RF-Photonic Channelizers [PDF]

Sensors, 2011
A theoretical study of RF-photonic channelizers using four architectures formed by active integrated filters with tunable gains is presented. The integrated filters are enabled by two- and four-port nano-photonic couplers (NPCs). Lossless and three individual manufacturing cases with high transmission, high reflection, and symmetric couplers are ...
Nagdi, Amr El, Liu, Ke, LaFave, Tim P., Hunt, Louis R., Ramakrishna, Viswanath, Dabkowski, Mieczyslaw, MacFarlane, Duncan L., Christensen, Marc P.   +7 more
openaire   +3 more sources

Free-space quantum key distribution transmitter system using WDM filter for channel integration

ETRI Journal
In this study, we report a transmitter system for free-space quantum key distri-bution (QKD) using the BB84 protocol, which does not require an internal alignment process, by using a wavelength-division multiplexing (WDM) filter and polarization-encoding
Minchul Kim, Kyongchun Lim, Joong-Seon Choe, Byung-Seok Choi, Kap-Joong Kim, Ju Hee Baek, Chun Ju Youn   +6 more
doaj   +1 more source

The role of channel integration quality in shaping consumer behavior in omnichannel and multi-channel retail

Journal of Open Innovation: Technology, Market and Complexity
Purpose: This study examines how channel integration quality influences consumer behavior—specifically satisfaction, purchase intentions, and brand loyalty—in omnichannel and multi-channel retail environments.
Nazym T. Tulebayeva, Zhanna T. Kozhamkulova, Taşkın Dirsehan   +2 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source