Results 71 to 80 of about 180,260 (215)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Comprehensive Analysis of CNN-Based Models for SNR Estimation

IEEE Access
Deep learning (DL) models offer a promising solution for Signal-to-Noise Ratio (SNR) estimation in wireless communication systems. Recently, regression-based DL approaches have been explored to overcome the limitations of classification-based methods ...
Abdullah Al Mahbub, Ijaz Ahmad, Seokjoo Shin   +2 more
doaj   +1 more source

SDR-Based 28 GHz mmWave Channel Modeling of Railway Marshaling Yard. [PDF]

Sensors (Basel), 2023
Liang Y, Li H, Tian Y, Li Y, Wang W.
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Millimeter-wave channel modeling in a VANETs using coding techniques. [PDF]

PeerJ Comput Sci, 2023
Ahmed A, Rasheed H, Bashir AK, Omar M.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Machine Learning-Based Method for LOS/NLOS Identification in V2V Environment

IEEE Access
Accurate identification of line-of-sight (LOS) and non-line-of-sight (NLOS) conditions is a critical challenge in wireless communication, particularly the vehicle-to-vehicle (V2V) channels, owing to the high dynamics inherent to V2V environments.
Yousra Chakkour, Vicent Miquel Rodrigo Penarrocha, Lorenzo Rubio, Herman Fernandez, Juan Reig   +4 more
doaj   +1 more source

Channel Modeling and Characteristics Analysis under Different 3D Dynamic Trajectories for UAV-Assisted Emergency Communications. [PDF]

Sensors (Basel), 2023
Zhang J, Liu Y, Huang J, Chang H, Zhang Z, Li J.   +5 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Research on UAV 3D Airspace Signal Strength Prediction Based on Physical Perception Feature Engineering

Mathematics
With the rapid development of the low-altitude economy, constructing an accurate unmanned aerial vehicle (UAV) air-to-ground channel model is crucial for ensuring communication quality.
Long Liu, Yapeng Wang, Xu Yang, Sio-Kei Im, Xuan Cheng, Lu Huang, Jiaqi Chen, Heng Guan   +7 more
doaj   +1 more source