Results 131 to 140 of about 17,118 (247)

Kalium channelrhodopsins are natural light-gated potassium channels that mediate optogenetic inhibition

, 2022
Elena G. Govorunova, Yueyang Gou, Oleg A. Sineshchekov, Hai Li, Xiaoyu Lu, Yumei Wang, Leonid S. Brown, François St-Pierre, Mingshan Xue, John L. Spudich   +9 more
openalex   +2 more sources

Organelle Optogenetics: Direct Manipulation of Intracellular Ca2+ Dynamics by Light

Frontiers in Neuroscience, 2018
As one of the ubiquitous second messengers, the intracellular Ca2+, has been revealed to be a pivotal regulator of various cellular functions. Two major sources are involved in the initiation of Ca2+-dependent signals: influx from the extracellular space
Toshifumi Asano, Hiroyuki Igarashi, Toru Ishizuka, Hiromu Yawo, Hiromu Yawo   +4 more
doaj   +1 more source

Dissecting inhibitory brain circuits with genetically-targeted technologies

Frontiers in Neural Circuits, 2014
The evolution of genetically targeted tools has begun to allow us to dissect anatomically and functionally heterogeneous interneurons, and to probe circuit function from synapses to behavior.
Dona Kim Murphey, Alexander M Herman, Benjamin R. Arenkiel, Benjamin R. Arenkiel, Benjamin R. Arenkiel   +4 more
doaj   +1 more source

Time-resolved infrared spectroscopic techniques as applied to Channelrhodopsin

Frontiers in Molecular Biosciences, 2015
Among optogenetic tools, channelrhodopsins, the light gated ion channels of the plasma membrane from green algae, play the most important role. Properties like channel selectivity, timing parameters or color can be influenced by the exchange of selected ...
Eglof eRitter, Ljiljana ePuskar, Franz J. Bartl, Emad F. Aziz, Emad F. Aziz, Peter eHegemann, Ulrich eSchade   +6 more
doaj   +1 more source

Structures of channelrhodopsin paralogs in peptidiscs explain their contrasting K+ and Na+ selectivities [PDF]

, 2023
Takefumi Morizumi, Kyumhyuk Kim, Hai Li, Elena G. Govorunova, Oleg A. Sineshchekov, Yumei Wang, Lei Zheng, Éva Bertalan, Ana‐Nicoleta Bondar, Azam Askari, Leonid S. Brown, John L. Spudich, Oliver P. Ernst   +12 more
openalex   +1 more source

Infrabarrels Are Layer 6 Circuit Modules in the Barrel Cortex that Link Long-Range Inputs and Outputs

Cell Reports, 2017
The rodent somatosensory cortex includes well-defined examples of cortical columns—the barrel columns—that extend throughout the cortical depth and are defined by discrete clusters of neurons in layer 4 (L4) called barrels.
Shane R. Crandall, Saundra L. Patrick, Scott J. Cruikshank, Barry W. Connors   +3 more
doaj   +1 more source

eLife Assessment: Diminishing neuronal acidification by channelrhodopsins with low proton conduction

, 2023
Jon T. Sack
openalex   +1 more source

Scanless two-photon excitation of channelrhodopsin-2

Nature Methods, 2010
Light-gated ion channels and pumps have made it possible to probe intact neural circuits by manipulating the activity of groups of genetically similar neurons. What is needed now is a method for precisely aiming the stimulating light at single neuronal processes, neurons or groups of neurons.
Papagiakoumou, Eirini, Anselmi, Francesca, Bègue, Aurélien, de Sars, Vincent, Glückstad, Jesper, Isacoff, Ehud, Emiliani, Valentina   +6 more
openaire   +3 more sources

Two Decades of Optogenetic Tools: A Retrospective and a Look Ahead

Advanced Genetics
Over the past two decades, optogenetics has evolved from a conceptual framework into a powerful and versatile technology for controlling cellular processes with light.
Xiao Duan, Mo Zhu, Shiqiang Gao
doaj   +1 more source

Tools, methods, and applications for optophysiology in neuroscience

Frontiers in Molecular Neuroscience, 2013
The advent of optogenetics and genetically-encoded photosensors has provided neuroscience researchers with a wealth of new tools and methods for examining and manipulating neuronal function in vivo.
Niklas eSmedemark-Margulies, Josef G Trapani   +1 more
doaj   +1 more source