Results 161 to 170 of about 18,335 (296)

Infrabarrels Are Layer 6 Circuit Modules in the Barrel Cortex that Link Long-Range Inputs and Outputs

Cell Reports, 2017
The rodent somatosensory cortex includes well-defined examples of cortical columns—the barrel columns—that extend throughout the cortical depth and are defined by discrete clusters of neurons in layer 4 (L4) called barrels.
Shane R. Crandall, Saundra L. Patrick, Scott J. Cruikshank, Barry W. Connors   +3 more
doaj   +1 more source

Retinal isomerization and water-pore formation in channelrhodopsin-2

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Channelrhodopsin-2 (ChR2) is a light-activated membrane ion channel that is widely used in biotechnological applications and optogenetics. Nonetheless, key elements of its structure, photocycle, and mechanism of action remain unresolved.
A. Ardèvol, G. Hummer
semanticscholar   +1 more source

Single‐cell genomics meets systems neuroscience: Insights from mapping the brain circuitry of stress

Journal of Neuroendocrinology, Volume 37, Issue 5, May 2025.
Abstract Responses to external and internal dangers is essential for survival and homeostatic regulation. Hypothalamic corticotropin‐releasing hormone neurons (CRHNs) play a pivotal role in regulating neuroendocrine responses to fear and stress.
Naresh K. Hanchate
wiley   +1 more source

Organelle Optogenetics: Direct Manipulation of Intracellular Ca2+ Dynamics by Light

Frontiers in Neuroscience, 2018
As one of the ubiquitous second messengers, the intracellular Ca2+, has been revealed to be a pivotal regulator of various cellular functions. Two major sources are involved in the initiation of Ca2+-dependent signals: influx from the extracellular space
Toshifumi Asano, Hiroyuki Igarashi, Toru Ishizuka, Hiromu Yawo, Hiromu Yawo   +4 more
doaj   +1 more source

Structural basis for channel conduction in the pump-like channelrhodopsin ChRmine

Cell, 2021
K. Kishi, Y. Kim, M. Fukuda, T. Kusakizako, Elina Thadhani, E.X.B. Byrne, Joseph M. Paggi, C. Ramakrishnan, Toshiki E. Matsui, K. Yamashita, T. Nagata, Masae Konno, Peter Y. Wang, Masato Inoue, Tyler Benster, Tomoko Uemura, Kehong Liu, Mikihiro Shibata, N. Nomura, S. Iwata, O. Nureki, R. Dror, Keiichi Inoue, K. Deisseroth, Hideaki E. Kato   +24 more
semanticscholar   +1 more source

An Optogenetic Approach for Investigation of Excitatory and Inhibitory Network GABA Actions in Mice Expressing Channelrhodopsin-2 in GABAergic Neurons

Journal of Neuroscience, 2016
To investigate excitatory and inhibitory GABA actions in cortical neuronal networks, we present a novel optogenetic approach using a mouse knock-in line with conditional expression of channelrhodopsin-2 (ChR2) in GABAergic interneurons. During whole-cell
Guzel Valeeva, T. Tressard, M. Mukhtarov, A. Baude, R. Khazipov   +4 more
semanticscholar   +1 more source

Channelrhodopsin-1 Phosphorylation Changes with Phototactic Behavior and Responds to Physiological Stimuli in Chlamydomonas

The Plant Cell, 2019
Rapid changes in the phosphorylation status of the light receptor ChR1 help the motile green alga Chlamydomonas reinhardtii adapt its phototactic sensitivity to varying environmental conditions.
M. Böhm, D. Boness, Elisabeth Fantisch, Hanna Erhard, Julia Frauenholz, Z. Kowalzyk, Nadin Marcinkowski, S. Kateriya, P. Hegemann, G. Kreimer   +9 more
semanticscholar   +1 more source

Cell type-specific and time-dependent light exposure contribute to silencing in neurons expressing Channelrhodopsin-2

eLife, 2014
Channelrhodopsin-2 (ChR2) has quickly gained popularity as a powerful tool for eliciting genetically targeted neuronal activation. However, little has been reported on the response kinetics of optogenetic stimulation across different neuronal subtypes ...
Alexander M Herman, Longwen Huang, Dona K Murphey, Isabella Garcia, Benjamin R Arenkiel   +4 more
doaj   +1 more source

Light Activation of Channelrhodopsin-2 in Excitable Cells of Caenorhabditis elegans Triggers Rapid Behavioral Responses [PDF]

, 2005
Georg Nagel, Martin Brauner, Jana Liewald, Nona Adeishvili, Ernst Bamberg, Alexander Gottschalk   +5 more
openalex   +1 more source

High-speed mapping of synaptic connectivity using photostimulation in Channelrhodopsin-2 transgenic mice [PDF]

, 2007
H. Wang, João Peça, M Matsuzaki, K Matsuzaki, Jun Noguchi, Li Qiu, D. Wang, F. Zhang, Edward S. Boyden, Karl Deisseroth, Haruo Kasai, Wendy Hall, Guoping Feng, George J Augustine   +13 more
openalex   +1 more source