Results 201 to 210 of about 226,086 (342)

Targeting GRP78 and the Proteostasis Network to Break the Therapeutic Ceiling in Neuroendocrine Prostate Cancer

iNew Medicine, EarlyView.
ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi, Md Rakibul Alam, Mithu Howlader, Mohammad Esfini Farahani, Lixiang Gu, Chun Li, Chripus Ngule, Kevin Fulp, Bolaji Owoyemi, Xinyi Wang, Samuel Nwadialo, Fatemeh Selani, Makumba Esoe, Obaleye Oluwafunminiyi, Zhiguo Li   +14 more
wiley   +1 more source

Heat Shock Protein Chaperome Is a Multi-Faceted Vector for Tumor Cell Migratory Activity, Invasion, and Metastasis. [PDF]

Cells
Fedorov V, Kurkin A, Fofanov G, Kaneva V, Kondratenko A, Combs SE, Shevtsov M.   +6 more
europepmc   +1 more source

Achieving superior therapeutic effects on methicillin‐resistant Staphylococcus aureus infection via simple sulfonation process for preparing zwitterionic photosensitizer

Interdisciplinary Medicine, EarlyView.
The sulfonated zwitterionic photosensitizer (PYSO3) is synthesized by reacting maleic anhydride derivatives with 4‐aminopyridine to form PY, followed by sulfonation with 1,4‐butane sultone. It exhibits both photothermal and photodynamic properties, enabling effective eradication of MRSA and biofilms, as well as promoting wound healing in mice ...
Changxu Zhu, Yin Li, Qiyun Deng, Ruixin Guo, Yu Huang, Wenyan Guo, Xi Chen, Ben Zhong Tang, Zhiming Wang, Lidan Chen, Zhaohui Sun   +10 more
wiley   +1 more source

The molecular chaperone GroEL in complex with denatured proteins: increasing stability against temperature and trypsin action

, 2018
Victor Marchenkov, Tatiana N. Melnik, Natalia Marchenko, Gennady V. Semisotnov   +3 more
openalex   +1 more source

Characterization of a pre-export enzyme–chaperone complex on the twin-arginine transport pathway [PDF]

, 2013
Jennifer M. Dow, Frank Gabel, Frank Sargent, Tracy Palmer   +3 more
openalex   +1 more source

Chaperone-mediated autophagy: roles in disease and aging

Cell Research, 2013
A. Cuervo, E. Wong
semanticscholar   +1 more source

Reduced Dietary Protein Induces Changes in the Dental Proteome

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Low dietary protein (10%) from normal (20%) does change protein expression in tooth proteome and alter developmental pathways. Among the significant protein expressions changes are actin‐based myosins, tooth, and bone development proteins. Perplexingly tooth size is not altered, suggesting more nuanced phenotypic response to low dietary protein in ...
Robert W. Burroughs, Christopher J. Percival, Natasha S. Vitek   +2 more
wiley   +1 more source

Stress response proteins in Borrelia burgdorferi: Subcellular localization and physiological function of the chaperone proteins Hsp60 and Hsp70; regulation of stress protein synthesis by exposure to Ixodes scapularis saliva (Acari: Ixodidae)

, 1995
Angelo Scorpio, Angelo Scorpio
openalex   +2 more sources

Chaperone machines for protein folding, unfolding and disaggregation

Nature reviews. Molecular cell biology, 2013
H. Saibil
semanticscholar   +1 more source

Serum predictors of native liver survival post‐Kasai: Systematic review and meta‐analysis

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives After hepatoportoenterostomy (HPE), a minority of biliary atresia (BA) patients reach adolescence without liver transplantation. Several serum markers have been suggested to better predict post‐HPE outcomes in BA patients. We aimed to identify serum predictors of native liver survival (NLS) in post‐HPE BA patients.
Ahmad Anouti, Hamza Dahshi, Thomas G. Cotter, Tebyan A. Rabbani, Natasha Corbitt, Sara Hassan   +5 more
wiley   +1 more source