Results 221 to 230 of about 226,086 (342)

New Biologic and Small Molecule Therapies for Hidradenitis Suppurativa

JEADV Clinical Practice, EarlyView.
ABSTRACT Hidradenitis suppurativa (HS) is an inflammatory skin disease that has historically been underdiagnosed and, until recently, under‐researched. Furthermore, the pathophysiology of HS is complex, and not fully understood. Just three biologic medications—adalimumab (anti‐TNF‐α), secukinumab (anti‐IL17A) and bimekizumab (anti‐IL17A/F) are licensed
Emily Pender, Rosalind Hughes, Brian Kirby   +2 more
wiley   +1 more source

A Novel Chaperone-Based Cancer Vaccination Enhances Immunotherapeutic Responsiveness Through T Cell Amplification and Tumor Immune Remodeling. [PDF]

Vaccines (Basel)
Cheng X, Liu Z, Cai J, Yu X, Guo C, Liu W, Manjili MH, Shah SA, Repasky EA, Subjeck JR, Wang X.   +10 more
europepmc   +1 more source

Antibodies against F1-ATPase alpha-subunit recognize mitochondrial chaperones. Evidence for an evolutionary relationship between chaperonin and ATPase protein families.

, 1994
Agustín Alconada, Ana I. Flores, Luis Blanco, José M. Cuezva   +3 more
openalex   +1 more source

Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu, Zexin Zhu, Lauren Fields, Hua Zhang, Lingjun Li   +4 more
wiley   +1 more source

The oncolytic avian reovirus p17 protein triggers chaperone-mediated autophagy by modulating Hsp90 and the T-complex protein-1 ring complex chaperones and co-chaperones to activate the IKK/NF-κB signaling. [PDF]

J Virol
Huang W, Li J-Y, Liao T-L, Lye L-F, Munir M, Liu H-J.   +5 more
europepmc   +1 more source

AI Chaperone: Awareness Chatbot for Alzheimer’s Disease

Su. Suganthi, Mr. Nithish Kumar R, Mr. Logeswaran S R, Mr. Rohan Kumar M, Mr. Hariprasad V   +4 more
openalex   +2 more sources

LRRK2 as a Potential Disease‐Modifying Target in Sporadic Parkinson's Disease

Movement Disorders, EarlyView.
Abstract A growing understanding of the role that leucine‐rich repeat kinase 2 (LRRK2) plays in Parkinson's disease (PD) supports continued focus on this enzyme as a therapeutic target for PD. Accumulating evidence suggests that there are phenotypic, neuropathologic, and biological similarities between sporadic PD (sPD) and familial forms in which ...
Anthony E. Lang, Robert A. Hauser, Lorraine V. Kalia, Bonnie Hersh, Zdenek Berger, Roy Llorens Arenas, Coro Paisan‐Ruiz, Kyle Fraser, Danna Jennings, Jillian H. Kluss, Sarah Huntwork‐Rodriguez, Anastasia G. Henry, J. Timothy Greenamyre   +12 more
wiley   +1 more source

Functional expression and properties of the tick α6 homomeric nicotinic acetylcholine receptor in <i>Xenopus laevis</i> oocytes. [PDF]

Curr Res Parasitol Vector Borne Dis
Cartereau A, Boussaine K, Taillebois E, Thany SH.   +3 more
europepmc   +1 more source

Histone Chaperone Deficiency in Arabidopsis Plants Triggers Adaptive Epigenetic Changes in Histone Variants and Modifications [PDF]

Michal Franek, Martina Nešpor Dadejová, Pavlína Pírek, Karolína Kryštofová, Tereza Dobisová, Zbyněk Zdráhal, Martina Dvořáčková, Gabriela Lochmanová   +7 more
openalex   +1 more source

Hsp90 Molecular Chaperone Inhibitors: Are We There Yet?

Clinical Cancer Research, 2012
L. Neckers, P. Workman
semanticscholar   +1 more source