Results 21 to 30 of about 20,108 (219)
Cation-mediated interplay of loops in chaperonin-10 [PDF]
, 2006 The ubiquitously occurring chaperonins consist of a large tetradecameric Chaperonin-60, forming a cylindrical assembly, and a smaller heptameric Chaperonin-10.
Sen, Ranjan +4 more
core +3 more sources
Chaperonins: Nanocarriers with Biotechnological Applications [PDF]
Nanomaterials, 2021 Chaperonins are molecular chaperones found in all kingdoms of life, and as such they assist in the folding of other proteins. Structurally, chaperonins are cylinders composed of two back-to-back rings, each of which is an oligomer of ~60-kDa proteins.
Sergio Pipaón +7 more
openaire +6 more sources
Complex Destabilization in the Mitochondrial Chaperonin Hsp60 Leads to Disease
Frontiers in Molecular Biosciences, 2020 Several neurological disorders have been linked to mutations in chaperonin genes and more specifically to the HSPD1 gene. In humans, HSPD1 encodes the mitochondrial Heat Shock Protein 60 (mtHsp60) chaperonin, which carries out essential protein folding ...
Alejandro Rodriguez +3 more
doaj +1 more source
Explicit solvent molecular dynamics simulations of chaperonin-assisted rhodanese folding [PDF]
, 2009 Chaperonins are known to facilitate the productive folding of numerous misfolded proteins. Despite their established importance, the mechanism of chaperonin-assisted protein folding remains unknown.
Li, Jinghai +10 more
core +1 more source
Folding for the Immune Synapse: CCT Chaperonin and the Cytoskeleton
Frontiers in Cell and Developmental Biology, 2021 Lymphocytes rearrange their shape, membrane receptors and organelles during cognate contacts with antigen-presenting cells (APCs). Activation of T cells by APCs through pMHC-TCR/CD3 interaction (peptide-major histocompatibility complex-T cell receptor ...
Noa Beatriz Martín-Cófreces +6 more
doaj +1 more source
Production of a recombinant form of early pregnancy factor that can prolong allogeneic skin graft survival time in rats [PDF]
, 2000 Early pregnancy factor (EPF), an extracellular chaperonin 10 homologue, has immunosuppressive and growth factor properties. In order to carry out more extensive studies on the in vivo characteristics of EPF, a recombinant form of the molecule has been ...
Murphy, R M +7 more
core +1 more source
Frontiers in Microbiology, 2016 Antibiotic resistance is an increasing challenge to modern healthcare. Aminoglycoside antiobiotics cause translation corruption and protein misfolding and aggregation in Escherichia coli.
Lise eGoltermann +2 more
doaj +1 more source
Journal of Extracellular Vesicles, 2023 Cell proteostasis includes gene transcription, protein translation, folding of de novo proteins, post‐translational modifications, secretion, degradation and recycling. By profiling the proteome of extracellular vesicles (EVs) from T cells, we have found
Amelia Rojas‐Gómez +17 more
doaj +1 more source
Chaperonin-Based Biolayer Interferometry To Assess the Kinetic Stability of Metastable, Aggregation-Prone Proteins [PDF]
, 2016 Stabilizing the folded state of metastable and/or aggregation-prone proteins through exogenous ligand binding is an appealing strategy for decreasing disease pathologies caused by protein folding defects or deleterious kinetic transitions.
Subhashchandra Naik (1911184) +12 more
core +1 more source
Biomolecules, 2014 Numerous human diseases are caused by protein folding defects where the protein may become more susceptible to degradation or aggregation. Aberrant protein folding can affect the kinetic stability of the proteins even if these proteins appear to be ...
Ana R. Correia +3 more
doaj +1 more source