Results 81 to 90 of about 37,307 (249)

The pathogen Moniliophthora perniciosa promotes differential proteomic modulation of cacao genotypes with contrasting resistance to witches´ broom disease [PDF]

, 2020
Background: Witches' broom disease (WBD) of cacao (Theobroma cacao L.), caused by Moniliophthora perniciosa, is the most important limiting factor for the cacao production in Brazil.
Correa, Stephany Cristiane, Cruz dos Santos, Everton, Gramacho, Karina Peres, Micheli, Fabienne, Pirovani, Carlos Priminho   +4 more
core   +1 more source

Bardet-Biedl Syndrome as a Chaperonopathy: Dissecting the Major Role of Chaperonin-Like BBS Proteins (BBS6-BBS10-BBS12)

Frontiers in Molecular Biosciences, 2017
Bardet-Biedl syndrome (BBS) is a rare genetic disorder that belongs to the group of ciliopathies, defined as diseases caused by defects in cilia structure and/or function. The six diagnostic features considered for this syndrome include retinal dystrophy,
M. Álvarez-Satta, S. Cástro-Sánchez, D. Valverde   +2 more
semanticscholar   +1 more source

Proteomic and Lipidomic Profiling of Immune Cell‐Derived Subpopulations of Extracellular Vesicles

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are heterogeneous and play important roles in intercellular communication, contributing to physiological and pathological processes. Since few markers currently exist to differentiate subtypes of EVs, this study aimed to determine proteomic and lipidomic differences among four EV subpopulations. Large and small EVs
Anna Lischnig, Nasibeh Karimi, Per Larsson, Karin Ekström, Rossella Crescitelli, Anna‐Carin Olin, Cecilia Lässer   +6 more
wiley   +1 more source

Dissecting intrinsic chaperonin activity [PDF]

Proceedings of the National Academy of Sciences, 1997
It has long been known that the linear sequence of amino acids along the polypeptide chains contains all the necessary information required to determine the correct three-dimensional structure of a protein (1). Indeed, a large number of proteins have been shown to refold spontaneously in vitro from an unfolded denatured state to the native folded state
G M, Clore, A M, Gronenborn
openaire   +2 more sources

Effects of confinement and crowding on folding of model proteins

, 2008
We perform molecular dynamics simulations for a simple coarse-grained model of crambin placed inside of a softly repulsive sphere of radius R. The confinement makes folding at the optimal temperature slower and affects the folding scenarios, but both ...
Baruah, Baukmketner, Cheung, Cieplak, Cieplak, Cieplak, Duroux, Ellis, Go, Hartl, Hoang, Honeycutt, Jewett, Kwiecinska, Luisi, M. Wojciechowski, Marek Cieplak, Matzke, Melo, Moilanen, Murtas, Rathore, Sulkowska, Sulkowska, Szymczak, Szymczak, Takagi   +26 more
core   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

The Function of Different Subunits of the Molecular Chaperone CCT in the Microsporidium Nosema bombycis: NbCCTζ Interacts with NbCCTα

Journal of Fungi
Chaperonin containing tailless complex polypeptide 1 (CCT) is a molecular chaperone protein that consists of eight completely different subunits and assists in the folding of newly synthesized peptides.
Sheng Xu, Ying Chen, Jingru Qi, Runpeng Wang, Erjun Wei, Qiang Wang, Yiling Zhang, Xudong Tang, Zhongyuan Shen   +8 more
doaj   +1 more source

Heat Shock Protein 60 (HSP60) detection by QCM Biosensor and Antibody Covered Gold Nanoparticles

International Journal of Electrochemical Science, 2021
Heat Shock Protein 60 (HSP60) is a 60 kDa weighting chaperonin that is an evolutionary conserved protein occurring in a wide number of organisms. It can serve as a plasma or blood serum biomarker of serious pathologies including cancer.
Miroslav Pohanka
doaj   +1 more source

Chaperonin CCT Checkpoint Function in Basal Transcription Factor TFIID Assembly

Nature Structural & Molecular Biology, 2018
TFIID is a cornerstone of eukaryotic gene regulation. Distinct TFIID complexes with unique subunit compositions exist and several TFIID subunits are shared with other complexes, thereby conveying precise cellular control of subunit allocation and ...
S. Antonova, M. Haffke, M. Haffke, E. Corradini, Mykolas Mikuciunas, T. Low, T. Low, L. Signor, R. M. V. Es, K. Gupta, E. Scheer, H. Vos, L. Tora, A. Heck, H. Timmers, I. Berger   +15 more
semanticscholar   +1 more source

A multi‐omics investigation of sarcopenia and frailty: Integrating genomic, epigenomic and telomere length data

Experimental Physiology, EarlyView.
Abstract Sarcopenia and frailty are complex geriatric syndromes influenced by a combination of genetic and environmental factors. Recent studies suggest that specific genetic variants, DNA methylation patterns and shortened telomeres are associated with age‐related diseases and might contribute to the development of both sarcopenia and frailty. In this
Valentina Ginevičienė, Erinija Pranckevičienė, Alina Urnikytė, Laura Jurkūnaitė, Kristijona Gutauskaitė, Rūta Dadelienė, Justina Kilaitė, Ieva Eglė Jamontaitė, Asta Mastavičiūtė, Ildus I. Ahmetov, Vidmantas Alekna   +10 more
wiley   +1 more source