Results 61 to 70 of about 21,272 (221)

Emerging Aspects of Jumbo Bacteriophages

Infection and Drug Resistance, 2021
Amina Nazir,1,2 Azam Ali,3 Hong Qing,1 Yigang Tong2 1Key Laboratory of Molecular Medicine and Biotherapy in the Ministry of Industry and Information Technology, Department of Biology, School of Life Sciences, Beijing Institute of Technology, Beijing ...
Nazir A, Ali A, Qing H, Tong Y
doaj  

HSPE1 deficiency underlies the crosstalk between metabolic dysfunction‐associated steatotic liver disease and age‐related macular degeneration

VIEW, EarlyView.
Rare‐earth ions act as multifunctional modifiers in perovskite solar cells by improving charge transport, suppressing oxygen vacancies, passivating defects, promoting grain growth, and enabling redox‐mediated stabilization. In addition, RE‐doped layers can expand spectral utilization through upconversion and downconversion, thereby enhancing light ...
Jiaqi Meng, Alimire Maihemuti, Yuan Yuan, Chao Chen, Mengchao Zhu, Hao Wang, Furong Zhu, Zhaodi Che, Jia Xiao, Xiangjia Zhu   +9 more
wiley   +1 more source

Structural And Functional Investigation Of Φ-El-Chaperonin Mediated Protein Folding [PDF]

, 2011
Chaperonins are ubiquitous, sequence related protein complexes that aid in the folding of nascent and misfolded polypeptides in an ATP driven pathway. Recently a GroEL-like, 860 kilo Dalton chaperonin protein complex was identified and isolated from the ...
Molugu, Sudheer Kumar
core   +2 more sources

Cryo-EM structure of human mitochondrial HSPD1

iScience, 2021
Summary: Chaperonins play an important role in folding newly synthesized or translocated proteins in all organisms. The bacterial chaperonin GroEL has served as a model system for the understanding of these proteins.
David P. Klebl, Matthew C. Feasey, Emma L. Hesketh, Neil A. Ranson, Heiko Wurdak, Frank Sobott, Robin S. Bon, Stephen P. Muench   +7 more
doaj   +1 more source

Olfactory proteomics reveals the capacity of the HDAC1 inhibitor pyroxamide to halt the α‐synuclein preformed fibrils‐induced damage in nasal epithelial, microglial and dopaminergic neuronal cell lines

Brain Pathology, EarlyView.
Omics‐driven drug repositioning reveals pyroxamide as a neuroprotective HDAC1 inhibitor in Parkinson's disease models. Abstract Parkinson's disease (PD) is the second most common neurodegenerative disorder mainly characterized by the degeneration of dopaminergic neurons originating in the substantia nigra (SN) pars compacta and projecting to other ...
Paz Cartas‐Cejudo, Marina De Miguel, Leire Extramiana, Mercedes Lachén‐Montes, Silvia Romero‐Murillo, Djordje Gveric, Joaquín Fernández‐Irigoyen, Enrique Santamaría   +7 more
wiley   +1 more source

cpnDB: A Chaperonin Sequence Database [PDF]

Genome Research, 2004
Type I chaperonins are molecular chaperones present in virtually all bacteria, some archaea and the plastids and mitochondria of eukaryotes. Sequences of cpn60 genes, encoding 60-kDa chaperonin protein subunits (CPN60, also known as GroEL or HSP60), are useful for phylogenetic studies and as targets for detection and identification of organisms ...
Hill, Janet, Penny, S. L., Crowell, K. G., Goh, S. H., Hemmingsen, Sean   +4 more
openaire   +2 more sources

Mycobacterium tuberculosis chaperonin 10 forms stable tetrameric and heptameric structures [PDF]

, 1995
The chaperonin activity of sequence-related chaperonin 10 proteins requires their aggregation into heptameric structures. We describe size-exclusion chromatography and ultracentrifugation studies that reveal that while Escherichia coli chaperonin 10 ...
Gianluca Fossati, Cölfen H, Zaliani A, Pierluigi Lucietto, Zaliani, A, Edith Chan, Lucietto, P., Giuliani, P., Mascagni P., Paolo Mascagni, Zaliani, A., Fossati G, Chan, E, Harding S, Harding, S., Helmut Cölfen, Lucietto P, Cölfen, H., Legname, Giuseppe, Anthony R. Coates, Coates, A., Cölfen, H, Lucietto, P, Mascagni, P., Fossati, G, Chan E, Giuliani P, Harding, S. E., Andrea Zaliani, Chan, E., Giuseppe Legname, Coates, A. R., Giuliani, P, Fossati, G., Steve Harding, Coates AR, Legname, G., Harding, S, Paola Giuliani, Coates, Ar   +39 more
core   +1 more source

Molecular Chaperone Networks in Plants: Maintaining Proteostasis and Enhancing Stress Resilience for Crop Improvement

Plant, Cell &Environment, EarlyView.
ABSTRACT Molecular chaperones play a central role in the plant proteostasis machinery by aiding the folding of nascent proteins, preventing aggregation, and repairing or degrading damaged proteins. These functions are especially essential during abiotic and biotic stress, which can destabilise cellular proteins and disrupt metabolic homoeostasis.
Mingfang Yang, Anqin Gao, Tsz‐Yan Chan, Hafiz Mamoon Rehman, Sehar Nawaz, Sehrish Bashir, Noman Mahmood, Muhammad Wajid Ullah, Chunlin Long, Hon‐Ming Lam, Muhammad Arif   +10 more
wiley   +1 more source

Multiple states of a Nucleotide-Bound Group 2 Chaperonin [PDF]

, 2008
Chaperonin action is controlled by cycles of nucleotide binding and hydrolysis. Here, we examine the effects of nucleotide binding on an archaeal group 2 chaperonin.
Quispe, J., Farr, G.W., Horwich, A.L., Stagg, Scott, Clare, Daniel K., Stagg, S., Farr, George W., Saibil, Helen R., Horwich, Arthur L., Quispe, Joel   +9 more
core   +1 more source

A multi‐omics investigation of sarcopenia and frailty: Integrating genomic, epigenomic and telomere length data

Experimental Physiology, EarlyView.
Abstract Sarcopenia and frailty are complex geriatric syndromes influenced by a combination of genetic and environmental factors. Recent studies suggest that specific genetic variants, DNA methylation patterns and shortened telomeres are associated with age‐related diseases and might contribute to the development of both sarcopenia and frailty. In this
Valentina Ginevičienė, Erinija Pranckevičienė, Alina Urnikytė, Laura Jurkūnaitė, Kristijona Gutauskaitė, Rūta Dadelienė, Justina Kilaitė, Ieva Eglė Jamontaitė, Asta Mastavičiūtė, Ildus I. Ahmetov, Vidmantas Alekna   +10 more
wiley   +1 more source