Results 51 to 60 of about 20,108 (219)

Comparative Genomics and Pathogenicity Analysis of Two Bacterial Symbionts of Entomopathogenic Nematodes: The Role of the GroEL Protein in Virulence

Microorganisms, 2022
Bacteria of the genera Xenorhabdus and Photorhabdus are symbionts of entomopathogenic nematodes. Despite their close phylogenetic relationship, they show differences in their pathogenicity and virulence mechanisms in target insects.
Abraham Rivera-Ramírez, Rosalba Salgado-Morales, Alfredo Jiménez-Pérez, Rebeca Pérez-Martínez, Blanca Inés García-Gómez, Edgar Dantán-González   +5 more
doaj   +1 more source

Chaperonin-Catalyzed Rescue of Kinetically Trapped States in Protein Folding [PDF]

, 2010
SummaryGroEL and GroES form a chaperonin nano-cage for single protein molecules to fold in isolation. The folding properties that render a protein chaperonin dependent are not yet understood.
Shi, Q. Y., Chakraborty, K., Qiaoyun Shi, Poschner, B. C., Sikor, M., Jiang, G. X., Manajit Hayer-Hartl, Guoxin Jiang, Sikor, Martin, Chakraborty, Kausik, F. Ulrich Hartl, Hayer-Hartl, M., Hayer-Hartl, Manajit, Poschner, Bernhard C., Chatila, Manal, Sinha, J., Chatila, M., Hartl, F. U., Sinha, Jyoti, Bernhard C. Poschner, Hartl, F. Ulrich, Kausik Chakraborty, Martin Sikor, Jiang, Guoxin, Lamb, Don C., Don C. Lamb, Lamb, D. C., Jyoti Sinha, Manal Chatila, Shi, Qiaoyun   +29 more
core   +1 more source

CCT2 Promotes Prostate Cancer Progression Through EIF3F‐Dependent Stabilization of FASN

Advanced Science, EarlyView.
ABSTRACT Prostate cancer (PCa) is increasingly recognized to be driven by dysregulated lipid metabolism. Although fatty acid synthase (FASN) is highly expressed in PCa, the mechanisms governing FASN protein stability and its functional integration into oncogenic lipid metabolism remain poorly defined.
Shun Xu, Yifan Zhang, Haolin Li, Shengyu Zhao, Xiaoran Dai, Qili Xu, Mintian Fei, Chun Li, Zhihui Zou, Baojun Wang, Li Zhang, Hui Wang, Ligang Zhang, Chaozhao Liang   +13 more
wiley   +1 more source

Proteome-Wide Analyis of Chaperonin-Dependent Protein Folding in Escherichia coli [PDF]

, 2006
In Escherichia coli, the cylindrical chaperonin GroEL and its cofactor GroES promote the folding of a fraction of newly synthesized polypeptide chains by acting as an Anfinsen cage.
Maier, T., Maier, Tobias
core  

Targeting WDR12 Unleashes T‐Cell‐Mediated Antitumor Activity in Melanoma by Destabilizing CD276

Advanced Science, EarlyView.
WDR12 cooperates with the chaperonin subunit CCT7 to maintain CD276 stability on tumor cells, suppressing T‐cell activity and promoting immune escape. SU14813, a small‐molecule WDR12 inhibitor, reduces CD276 stability and relieves CD276‐mediated T‐cell suppression.
Jie Pan, Ruimin Chang, Meng Zhang, Qian Dong, Guanxiong Zhang, Xiang Chen, Mingliang Chen, Lixia Lu, Xiaowei Liang, Yeye Guo, Juan Su   +10 more
wiley   +1 more source

Mycobacterium tuberculosis chaperonin 10 forms stable tetrameric and heptameric structures [PDF]

, 1995
The chaperonin activity of sequence-related chaperonin 10 proteins requires their aggregation into heptameric structures. We describe size-exclusion chromatography and ultracentrifugation studies that reveal that while Escherichia coli chaperonin 10 ...
Gianluca Fossati, Cölfen H, Zaliani A, Pierluigi Lucietto, Zaliani, A, Edith Chan, Lucietto, P., Giuliani, P., Mascagni P., Paolo Mascagni, Zaliani, A., Fossati G, Chan, E, Harding S, Harding, S., Helmut Cölfen, Lucietto P, Cölfen, H., Legname, Giuseppe, Anthony R. Coates, Coates, A., Cölfen, H, Lucietto, P, Mascagni, P., Fossati, G, Chan E, Giuliani P, Harding, S. E., Andrea Zaliani, Chan, E., Giuseppe Legname, Coates, A. R., Giuliani, P, Fossati, G., Steve Harding, Coates AR, Legname, G., Harding, S, Paola Giuliani, Coates, Ar   +39 more
core   +1 more source

Streamlining Diagnosis of Bardet–Biedl Syndrome: New Diagnostic Algorithm With Updated Criteria

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Considerable advances have been made in our understanding of Bardet–Biedl syndrome (BBS), particularly in its core clinical features and molecular genetics, warranting an update to the existing diagnostic criteria framework. Using a rigorous, evidence‐based, and consensus‐driven process, a multidisciplinary group of international experts and ...
Jeremy J. Pomeroy, Jesse Richards, Brooke R. Sweeney, Seema Kumar, Katie E. Queen, Joshua Zaritsky, Carl H. Cramer, Elias I. Traboulsi, Brittni A. Scruggs, Erica E. Davis, Ekaterina Keifer, Emma McGibbon, Timothy Ogden, Bendert De Graaf, Tonia Hymers, Elizabeth Forsythe, Philip Beales   +16 more
wiley   +1 more source

Multiple states of a Nucleotide-Bound Group 2 Chaperonin [PDF]

, 2008
Chaperonin action is controlled by cycles of nucleotide binding and hydrolysis. Here, we examine the effects of nucleotide binding on an archaeal group 2 chaperonin.
Quispe, J., Farr, G.W., Horwich, A.L., Stagg, Scott, Clare, Daniel K., Stagg, S., Farr, George W., Saibil, Helen R., Horwich, Arthur L., Quispe, Joel   +9 more
core   +1 more source

Heat Shock Protein 60 (HSP60) detection by QCM Biosensor and Antibody Covered Gold Nanoparticles

International Journal of Electrochemical Science, 2021
Heat Shock Protein 60 (HSP60) is a 60 kDa weighting chaperonin that is an evolutionary conserved protein occurring in a wide number of organisms. It can serve as a plasma or blood serum biomarker of serious pathologies including cancer.
Miroslav Pohanka
doaj   +1 more source

Proteomic signatures of equine dental tooth tissues in ageing and disease

Equine Veterinary Journal, EarlyView.
Abstract Background Ageing and dental disease in horses lead to structural and functional deterioration of dental tissues, yet their molecular signatures remain poorly characterised. Understanding how these processes alter the protein composition of enamel, dentin, cementum and pulp is essential for improving equine oral health and identifying ...
Anders Jensen, Danae Emilie Zambouli, Iris Gringel, Zoe Nugent, Kazuhiro Yamamoto, Lee Cooper, Andrew J. Peffers, Guido Rocchigiani, Mandy J. Peffers   +8 more
wiley   +1 more source