Results 111 to 120 of about 1,651,705 (291)

Improving Walking Energy Efficiency in Transtibial Amputees Through the Integration of a Low-Power Actuator in an ESAR Foot

open access: yesIEEE Transactions on Neural Systems and Rehabilitation Engineering
Reducing energy consumption during walking is a critical goal for transtibial amputees. The study presents the evaluation of a semi-active prosthesis with five transtibial amputees.
Alessandro Mazzarini   +12 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

The nature of natural: defining natural character for the New Zealand context [PDF]

open access: yes, 2010
New Zealand has a long-standing statutory policy goal to preserve the natural character of the coastal environment and various freshwater environments and their margins. In the absence of an authoritative definition, it has not been possible to develop a
Bornman, Janet   +8 more
core   +1 more source

Penyuluhan perilaku hidup bersih dan sehat (PHBS) melalui cuci tangan pakai sabun (CTPS) kepada siswa SDN Panunggangan 4 sebagai upaya menanamkan nilai bela negara

open access: yesAbdimas Altruis
Clean handwashing practices are one of the fundamental factors of Clean and Healthy Living Behavior (PHBS), making it essential to instill this habit from an early age.
Audrey Gondokusumo Widjaja   +4 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Character strengths and virtues in relation to well-being in gay and lesbian individuals [PDF]

open access: yes, 2010
The purpose of this study was to apply concepts of virtue and positive psychology to the understanding of well-being in gay and lesbian individuals. Ninety-two self-identified gay and lesbian university students between the ages of 18 and 30 completed an
Miller, Deborah J.
core  

Youth moral development in a Chinese context: an empirical study of Self-Other Knowledge Asymmetry between self, parents, and teachers

open access: yesCogent Education
Moral education and fostering youth character development have become the foci of Chinese moral education; yet most existing studies are confined to the Chinese education community and not shared with an international audience.
Yan Huo   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

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