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Series Editor's Preface - Character Studies Series

Character Studies promotes sophisticated literary analysis through the concept of character. It demonstrates the necessity of linking character analysis to texts'; themes, issues and ideas, and encourages students to embrace the complexity of literary ...
Chantler, Ashley
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Penyuluhan perilaku hidup bersih dan sehat (PHBS) melalui cuci tangan pakai sabun (CTPS) kepada siswa SDN Panunggangan 4 sebagai upaya menanamkan nilai bela negara

Abdimas Altruis
Clean handwashing practices are one of the fundamental factors of Clean and Healthy Living Behavior (PHBS), making it essential to instill this habit from an early age.
Audrey Gondokusumo Widjaja, Nicholas, Timotius Enrico Valentino, Ferdy Anthonius, Christian Siregar   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Longitudinal Associations Between Adolescents' Social Media Use and Character Development

This study is designed to assess associations between social media use and ...
Jacqueline Nesi, Brian Galla, Anne Maheux, Savannah R. Roberts, Sophia Choukas-Bradley   +4 more
core   +2 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Trip Detection Algorithms for Healthy and Amputee Individuals

IEEE Transactions on Neural Systems and Rehabilitation Engineering
Amputation disrupts normal gait biomechanics, reducing strength, balance, and toe clearance. These factors contribute to an increase in falls in amputees, leading to both physical injury and psychological burden.
Eugenio Anselmino, Tommaso Ciapetti, Michele Piazzini, Claudio Macchi, Alberto Mazzoni, Silvestro Micera, Arturo Forner-Cordero   +6 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Developing RADEC Learning Model to Strengthen Religious Character and Critical Thinking in Elementary Schools

Jurnal Inovasi Pendidikan dan Sains
This research aims to develop a valid RADEC-based learning model for strengthening religious character values and improving critical thinking skills of elementary school students.
Nana Suryana, Wahyu Sopandi, Yadi Ruyadi
doaj   +1 more source