Results 61 to 70 of about 2,841,692 (252)
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Ion exchange chromatography – basic principles and application [PDF]
, 2011 Ion-Exchange Chromatography (IEC) allows for the separation of ionizable molecules on the basis of differences in charge properties. Its large sample-handling capacity, broad applicability (particularly to proteins and enzymes), moderate cost, powerful ...
Dowling, Oonagh +3 more
core +2 more sources
Differential Analysis of Electron Saddle-Swap Oscillations in Ar16+ Collisions with H(1s)
AtomsIn this work, state-selective electron-capture processes in collisions of Ar16+ with ground-state hydrogen are analyzed in classical terms by means of the classical trajectory Z-CTMC method.
Nicolas Bachi +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Design of N2 + He two-stage stripper for CSR1 [PDF]
EPJ Web of ConferencesCharge stripper ring 1 (CSR1) is a circumferential ring with a stripper installed inside to improve the charge conversion efficiency, which is considered to be constructed as a future project.
Miyake Yasuto +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Temperature effect on space charge dynamics in XLPE insulation [PDF]
, 2007 This paper reports on space charge evolution in crosslinked polyethylene (XLPE) planar samples approximately 1.20 mm thick subjected to electric stress level of 30 kVdc/mm under four temperature 25 oC, 50 oC, 70 oC and 90 oC for 24 hours.
Chong, Y L, Chen, G, Ho, Y F F
core +2 more sources
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
Big Ideas Exchange Highlights Struggle for Cyber Advantage [video]
, 2019 Naval Postgraduate School (NPS) faculty and students researching the cutting-edge of how the U.S. can gain an advantage in cyberspace shared their game-changing research during the latest Big Ideas Exchange (BIX), Nov.
core +2 more sources
FEBS Open Bio, EarlyView.Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source