Results 61 to 70 of about 8,865,093 (252)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Generalizing "Charge without Charge" to Obtain Classical Analogs of Short-Range Interactions [PDF]

, 2007
Several decades ago, Wheeler and Misner presented a model of electric charge ("charge without charge") based on the topological trapping of electric field lines in wormholes.
Sharlow, Mark
core  

Structure of space charge density measurement instrument.

, 2017
Structure of space charge density measurement instrument.
Jianxun Lv (3615797), Haiwen Yuan (3615794), Dawei Deng (1678783), Yong Ju (1404961)   +3 more
core   +1 more source

Calculation of Blasting Damage Zone Radius of Different Charge Structures in Burnt Rock

Applied Sciences
The radius of the failure area after a blasting fracture process of burnt rock is affected by joint fissures, does not conform to the existing theoretical calculation formula and the distribution law of the failure area also changes. The fracture area is
Zhengzhao Jia, Hongjie Li, Wei Li, Jie Yan   +3 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Determining Partial Atomic Charges for Liquid Water: Assessing Electronic Structure and Charge Models [PDF]

, 2020
Partial atomic charges provide an intuitive and efficient way to describe the charge distribution and the resulting intermolecular electrostatic interactions in liquid water.
Christine, Isborn, Bowen, Han, Liang, Shi   +2 more
core   +2 more sources

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Research on Optimal Charge Structure Selection and Active Control Methods for Subgrade Bench Blasting Based on Multi‐Objective Optimization

Energy Science & Engineering
To reduce the peak vibration velocity (PPV) of subgrade bench blasting vibration, the control variable method was used to analyze the blasting effect of different charging methods.
Sun Yong, Zhang Zhongshuai, Tian Chenglin, Wang Qingbiao, Shi Zhenyue, Wang Keyong   +5 more
doaj   +1 more source