Results 81 to 90 of about 702,376 (277)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

A Comprehensive Review on Efficiency Enhancement of Wireless Charging System for the Electric Vehicles Applications

IEEE Access
The increasing Electric Vehicle (EV) market is driven by the desire for more efficient and reliable approaches to recharge EV batteries. Among various charging methodologies for EVs, Wireless Power Transfer (WPT) has gained more attention from EV users ...
Venkatesan Ramakrishnan, Dominic Savio A, Balaji C, Narayanamoorthi Rajamanickam, Hossam Kotb, Ali Elrashidi, Waleed Nureldeen   +6 more
doaj   +1 more source

Characterizing Smartphone Power Management in the Wild

, 2016
For better reliability and prolonged battery life, it is important that users and vendors understand the quality of charging and the performance of smartphone batteries. Considering the diverse set of devices and user behavior it is a challenge.
Hoque, Mohammad A., Tarkoma, Sasu
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Estimating the Benefits of Electric Vehicle Smart Charging at Non-Residential Locations: A Data-Driven Approach

, 2015
In this paper, we use data collected from over 2000 non-residential electric vehicle supply equipments (EVSEs) located in Northern California for the year of 2013 to estimate the potential benefits of smart electric vehicle (EV) charging.
Berges, Mario, Black, Douglas, Hug, Gabriela, Kara, Emre Can, Kiliccote, Sila, Macdonald, Jason S.   +5 more
core   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Economic Viability Study of an On-Road Wireless Charging System with a Generic Driving Range Estimation Method

Energies, 2016
The economic viability of on-road wireless charging of electric vehicles (EVs) strongly depends on the choice of the inductive power transfer (IPT) system configuration (static or dynamic charging), charging power level and the percentage of road ...
Aditya Shekhar, Venugopal Prasanth, Pavol Bauer, Mark Bolech   +3 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Efficient Bidirectional Wireless Power Transfer System Control Using Dual Phase Shift PWM Technique for Electric Vehicle Applications

IEEE Access
The emerging bidirectional wireless power transfer (BWPT) technology provides improved flexibility without requiring human intervention by facilitating smooth Grid to Vehicle (G2V) and Vehicle to Grid (V2G) operations.
Murugan Venkatesan, R. Narayanamoorthi, Kareem M. AboRas, Ahmed Emara   +3 more
doaj   +1 more source