Results 51 to 60 of about 186,673 (282)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Constitucionalismo e Checks and Balances: Teoria e Pesquisa Empírica
Prim@ Facie, 2012 Este artigo tem por objetivo apresentar e discutir as principais pesquisas empíricas sobre Constitucionalismo e Checks and Balances. O artigo está dividido da seguinte forma: a primeira parte versará sobre a trajetória do conceito de constitucionalismo ...
Saulo Felipe Costa +2 more
doaj +4 more sources
JSP: Jurnal Ilmu Sosial dan Ilmu Politik, 2002 The attempt to question the legitimacy of President Abdurrahman Wahid has led to reemergence of the idea of having a direct election for the filling the President post, instead of having an indirect election, namely through the People's Consultative ...
Afan Gaffar
doaj +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Проблеми Законності, 2015 The hypothesis of formation of the post-soviet authoritarianism nominated by foreign scholars has been considered. The features of the regulation of certain elements of the model of checks and balances in the constitution of the former Soviet Union have ...
К. О. Закоморна
doaj +1 more source
Analisis Kontestasi Kelembagaan DPD Dan Upaya Mengefektifkan Keberadaannya [PDF]
, 2008 In considering the principle of check and balances in legislature matter, the grand theme should be proposed in this context is how to guarantee checks and balances within the legislative branch and that principle are implemented properly and reliably ...
Marzuki, M. (Masnur)
core +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
, 2013 This essay reviews Power and Constraint: The Accountable Presidency After 9/11 by Jack Goldsmith (2012). With The Terror Presidency, Professor Jack Goldsmith wrote, hands down, the very best analysis of the national security issues surrounding President ...
Katyal, Neal K.
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source