Results 61 to 70 of about 34,002 (273)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Determinants of Presidential Veto in Semi-presidential System: Empirical Insights from Poland

open access: yesEkonomista
The primary objective of this paper is to investigate the determinants influencing the use of presidential vetoes in Poland, with a particular focus on the role of the anti-pluralist attitude of government and intra-executive identity differences, i.e ...
Anna Lewczuk
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

'Constitución mixta' en la república de Florencia a principios del siglo XVI

open access: yesGerión, 2019
En la tradición occidental ha predominado una única interpretación de la constitución mixta, la que aplicó Polibio a Esparta y a Roma. Sin embargo, en el pensamiento político griego existieron versiones anteriores y menos rígidas de esa idea de mezclar ...
Laura Sancho Rocher
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Pengaruh Pembatasan Kekuasaan Presiden Terhadap Praktik Ketatanegaraan Indonesia

open access: yesJurnal Konstitusi, 2016
This research effort to search the contents president power restriction in achieving constitutional governmant in Indonesia. The restriction power of president related to restriction of president authority.
Chrisdianto Eko Purnomo
doaj   +1 more source

Architecture of Indonesia's Checks and Balances

open access: yes, 2017
Research on "checks and balances" in legal studies often raises high quality questions such as, is the checks and balances a doctrine, principle, or legal theory, or maybe precisely the formula of power in politics.
Ibnu Sina Chandranegara
semanticscholar   +1 more source

Checks and Balances Mechanism in Islamic Constitutionalism: A Critical Reflection

open access: yesJournal of Islamic Studies and Culture, 2019
This article examines the issue of mechanism of controlling the power balance amongst three arms of the government (separation of powers) in Islamic constitutionalism.
N. Hosen
semanticscholar   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Strengthening of Institutional MPR in the Constitutional System of the Republic of Indonesia

open access: yesHasanuddin Law Review, 2015
The 1945 amendment were made in the sessions of the Assembly 1999-2000 has revolutionized state system of Indonesia, including concerning the status and function of state institutions. People’s Consultative Assembly (MPR) as one of the state institutions
Galang Asmara
doaj  

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