Results 121 to 130 of about 70,844 (290)

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Advanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang   +18 more
wiley   +1 more source

Overall survival in lower IPSS risk MDS by receipt of iron chelation therapy, adjusting for patient‐related factors and measuring from time of first red blood cell transfusion dependence: an MDS‐CAN analysis [PDF]

, 2017
Heather A. Leitch, Ambica Parmar, Richard A. Wells, Lisa Chodirker, Nancy Zhu, Thomas J. Nevill, Karen Yee, Brian Leber, Mary‐Margaret Keating, Mitchell Sabloff, Eve St. Hilaire, Rajat Kumar, Robert Delage, Michelle Geddes, John M. Storring, Andrea Kew, April Shamy, Mohamed Elemary, Martha Lenis, Alexandre Mamedov, Jessica Ivo, Janika Francis, Liying Zhang, Rena Buckstein   +23 more
openalex   +1 more source

A Systemic Selective Modified mRNA Delivery Platform for Preventing Chemotherapy‐Induced Cardiotoxicity

Advanced Science, EarlyView.
In Yoo and Mainkar et al., we present a minimally invasive, CM‐selective modRNA delivery system encapsulated in lipid nanoparticles for intravenous (IV) administration. This platform enables selective cardiac translation of therapeutic modRNA but suppresses expression in off‐target tissues, including tumors.
Jimeen Yoo, Gayatri Mainkar, Matteo Ghiringhelli, Bernardo Gindri Dos Santos, Magdalena M. Żak, Keerat Kaur, Ann Anu Kurian, Matthew Adjmi, Segev Sharon, Eftychia Markopoulou, Lucia Žigová, Daniela Hirsch, Sydney Pessin, Rachel Hanan, Juan Luis Escano Abreu, Niki Brisnovali, Nicole Dubois, Leigh Goedeke, Mengcheng Shen, Lior Zangi   +19 more
wiley   +1 more source

A Mussel‐Inspired Bioadhesive Patch to Selectively Kill Glioblastoma Cells

Advanced Science, EarlyView.
An innovative mussel‐inspired bioadhesive patch has been developed for post‐surgical glioblastoma treatment. The patch, which adheres strongly in biological environments, releases a localized treatment. This treatment, acting via reactive oxygen species, shows specific toxicity to glioblastoma cells.
Jose Bolaños‐Cardet, Sara Pugliese, Jordi Bruna, Daniel Ruiz‐Molina, Salvio Suárez‐García, Victor J. Yuste   +5 more
wiley   +1 more source

Removal of pamidronate from bone in rats using systemic and local chelation

, 2015
R. Nicole Howie, Maryka H. Bhattacharyya, Mohamed E. Salama, Mona El Refaey, Carlos M. Isales, James L. Borke, Asma Daoudi, Fardous Medani, Mohammed Elsalanty   +8 more
openalex   +1 more source

Chelation activity of N'1,N'6-bis((E)-3,4-dihydroxybenzylidene)adipohydrazide towards some transition metal ions [PDF]

, 2016
Ahmed A. El‐Asmy, Bakir Jeragh, Mayada S. Ali   +2 more
openalex   +1 more source

All‐Round Talent: Unique Zinc Guanidine Catalyst Performs Efficiently in Synthesis and Chemical Recycling of (Bio)Polyesters

Advanced Science, EarlyView.
A new zinc hybrid guanidine catalyst [Zn{(R,R)TMGNMe2(1,2)ch}2](OTf)2 (C1) shows very high catalytic activity in the polymerization of cyclic esters and in the depolymerization of these polyesters. Using C1 in the ring‐opening polymerization of lactide and caprolactone under industrially relevant conditions, astonishing rate constants of the same order
Tabea Becker, Koki Takeuchi, Carolin Süßmuth, Frederico Boekhoff, Martin A. Schäfer, Shunsuke Kato, Alexander Hoffmann, Takashi Hayashi, Sonja Herres‐Pawlis   +8 more
wiley   +1 more source

Chelation Therapy for Rare Earth Element Toxicity: Current Evidence, Challenges and Future Directions. [PDF]

Basic Clin Pharmacol Toxicol
Domingo JL.
europepmc   +1 more source

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source

d-Penicillamine-loaded MIL-100(Fe) for precise targeted copper chelation in Wilson's disease. [PDF]

RSC Adv
Fang W, Wang Q, Yang H, Lv H, Li M, Liu Y, Shu C, Wang D.   +7 more
europepmc   +1 more source