Results 31 to 40 of about 66,247 (299)
Medical Toxicology Case Presentations: to Chelate or Not to Chelate, Is that the Question? [PDF]
Journal of Medical Toxicology, 2013 Four case studies described in this article were presented to a panel of physicians participating in the ACMT "Use and Misuse of Metal Chelation Therapy" Symposium in February 2012. The individuals who participated in the panel are listed in the appendix.
Charles A. McKay +2 more
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Chelating Silicone Dendrons: Trying to Impact Organisms by Disrupting Ions at Interfaces
Molecules, 2022 The viability of pathogens at interfaces can be disrupted by the presence of (cationic) charge and chelating groups. We report on the synthesis of silicone dendrimers and linear polymers based on a motif of hexadentate ligands with the ability to capture
Miguel Melendez-Zamudio +2 more
doaj +1 more source
Toxics, 2022 Copper (Cu), being an essential trace metal, plays several roles in biological processes, though exposure to Cu can be potentially toxic to the brain and a few other soft organs.
Jayant Patwa +2 more
doaj +1 more source
Antioxidants, 2023 Copper is an essential metal ion that is involved in critical cellular processes, but which can also exhibit toxic effects through its ability to catalyze reactive oxygen species (ROS) formation. Dysregulation of copper homeostasis has been implicated in
Anastasia Esther Behar, Galia Maayan
doaj +1 more source
Vitamin K and Calcium Chelation in Vascular Health
Biomedicines, 2023 The observation that the extent of artery calcification correlates with the degree of atherosclerosis was the background for the alternative treatment of cardiovascular disease with chelator ethylenediamine tetraacetate (EDTA).
Jan O. Aaseth +3 more
doaj +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
The Regulation of Trace Metal Elements in Cancer Ferroptosis
Advanced Biology, EarlyView.The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang +5 more
wiley +1 more source
Jacks of metal(loid) chelation trade in plants – an overview
Frontiers in Plant Science, 2015 Varied environmental compartments including soils are being contaminated by a myriad toxic metal(loid)s (hereafter termed as ‘metal/s’) mainly through anthropogenic activities. These metals may contaminate food chain and bring irreparable consequences in
Naser A. Anjum +15 more
doaj +1 more source
Advanced Engineering Materials, EarlyView.Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley +1 more source
Chelation in Metal Intoxication [PDF]
International Journal of Environmental Research and Public Health, 2010 Chelation therapy is the preferred medical treatment for reducing the toxic effects of metals. Chelating agents are capable of binding to toxic metal ions to form complex structures which are easily excreted from the body removing them from intracellular or extracellular spaces.
Swaran J.S. Flora, Vidhu Pachauri
openaire +3 more sources