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Iron Toxicity and Chelation Therapy
International Journal of Hematology, 2002Iron is an essential mineral for normal cellular physiology, but an excess can result in cell injury. Iron in low-molecular-weight forms may play a catalytic role in the initiation of free radical reactions. The resulting oxyradicals have the potential to damage cellular lipids, nucleic acids, proteins, and carbohydrates; the result is wide-ranging ...
Bruce R. Bacon +2 more
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Iron-chelation therapy: an update
The Hematology Journal, 2004Chronically transfused patients develop iron overload that leads to organ damage and ultimately to death. The introduction of the iron-chelating agent, desferrioxamine mesylate, dramatically improved the life expectancy of these patients. However, the very demanding nature of this treatment (subcutaneous continuous infusion via a battery-operated ...
Dino Veneri, Massimo Franchini
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Seminars in Hematology, 2001
Iron chelators are used in clinical practice to protect patients from the complications of iron overload and iron toxicity because there is no physiologic way for excess iron to be actively excreted. Deferoxamine, the only iron-chelating agent available for clinical use in the United States, is administered as a prolonged (8 to 24 hours) infusion ...
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Iron chelators are used in clinical practice to protect patients from the complications of iron overload and iron toxicity because there is no physiologic way for excess iron to be actively excreted. Deferoxamine, the only iron-chelating agent available for clinical use in the United States, is administered as a prolonged (8 to 24 hours) infusion ...
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Lead toxicity and chelation therapy
American Journal of Health-System Pharmacy, 2007Common sources of lead exposure, the primary clinical effects of lead toxicity, and current recommendations for managing lead toxicity, including chelation therapy, are reviewed.Common sources of lead exposure in children and adults include industrial and mining activities, paint, dust, soil, water, air, the workplace, food, trinkets, ethnic folk ...
Wayne R. Snodgrass, Rebeca C. Gracia
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Chelation: Therapy or quackery?
Pharmacy Today, 2013More than 110,000 American adults used chelation in 2007, according to the National Health Interview Survey—a signifi cant increase from the 66,000 patients using this therapy in 2002. Although chelation therapy is indicated for acute poisoning due to lead, iron, and other toxic compounds, much of its use has been by alternative medicine providers ...
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Chelation Therapy in Lead Nephropathy
Southern Medical Journal, 1975Although treatment has been well defined for childhood lead poisoning and for industrial lead exposure, the treatment of lead nephropathy has been poorly studied. The available chelating agents are reviewed and the results of treatment in 17 cases of lead nephropathy are shown.
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2013
Chelation therapy is the medical treatment for reducing the toxic effect of metals. Chelating agents are organic compounds that are capable of linking to metal ions to form less toxic species that are easily excreted from the body. Chelators bind metals and remove them from intracellular or extracellular spaces.
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Chelation therapy is the medical treatment for reducing the toxic effect of metals. Chelating agents are organic compounds that are capable of linking to metal ions to form less toxic species that are easily excreted from the body. Chelators bind metals and remove them from intracellular or extracellular spaces.
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Chelation therapy for atherosclerosis [PDF]
Medical Journal of Australia, 1985 openaire +4 more sources
Adverse Effects of Chelation Therapy
JAMA: The Journal of the American Medical Association, 1983To the Editor.— I read the report inThe Journal1indicating that edetate disodium had not been shown in any well-designed control trials to be beneficial to patients with coronary artery disease and that the safety of using such was questionable. Nevertheless, some physicians have been using this treatment.
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